Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_036983795.1
Location
CM072795.1:9125166-9135141[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.92 4.1e+03 -2.0 0.1 44 60 406 422 403 440 0.79
2 3 3.4 1.5e+04 -3.8 0.0 40 50 446 456 445 466 0.82
3 3 1.4e-17 6.4e-14 51.9 0.2 6 69 546 609 541 617 0.91

Sequence Information

Coding Sequence
ATGAAGCGGCGGCGTATAGCGCGGTCGCGTGGTAAAGGGATACCGCCTTTGAGGATGATGAAAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGTTGATGTGCAAGATGCTCGAGCCAAGGGTTTACCGCTTCATAGGTTTCCAAAAGACAGCAATTTGAGAAGTAAATGGTTAGCCAGTGGTGGATTCGAGACAACTTTTAAACCTTCACCGGGTCAGGTTGTCTGCCACAGACATTTTAAACGTGCTGATTACGAAGCCGCTAAGGGACATAAATTACTTCTGCGTAAAGGCAGTGTTCCGTCAGTTTTTGCAGATTATGACAATCATCCAGATCCTGTGATTATGTCTGTGAAATCATCAACTTCTTATGCGCAGGAGGATTTGGATCTCATTAATTctgagattttaaatttagagcaATCTATTTCACCATTGGTATCTGAAGCAAAAACACAAAAGATTGATACCTGTAAAGAAACATGTTCTTCTGAACCAGCATTATTAGCTGATTCTTCTAATGAGTTAGATTCCAAAGAAATACTTGACAatggatataaaaattcgaatgtaaaagaaaaaaacagtataaaacaagaaaaagtTCCTGCACAACAGGAAGTTAATGAAAATTCGGAAGTACAAGTAAATACTGTTGCAGTGCAGTTAGGAATTGTAGAATCAGATATAGCAATGAAggatatacaaaaaaatttgatcataaaagaagaattaaaaaacgtTAAAATGGAGGATGAAAAAGTATTTGAGAAATCAGATGAATTAAAACCAAAGATTTTGAACCGAGgtggattaaaattttttcctGGTGCCAAATTAGAAGCAAAagatttcaatgaaaaatgGTATTCAGCTAAAGTAGTAGAAACTGATTGGGATGAAAGAGAAGTCTTGATTCATTTCGATAAATGGAGCTCAAGATTTGATGAATGGATACCTATGGATAGCTCCAGATTACGTGTATTACAAACACAATCAAAtGAAGAAACTTGGGATCTACCATCTTCggaagaaaaaatgaaagatttttcAGTAGGAGAAAGGATACTTGCTACATGGGCTGATGGTAGAAAATATCCAGCCAAAGTGAATGCAGTTTTAGGGAATGATAGGTATGATGTACTCTTTGATGATGGATATGCAAAGACAGTTAAATCgtcaaaaatgacaaaaattactCCAACATCCACAAAGCAATTTAATCAAACCGAAGAATATATAGGAAGCAAACAAGAAAGAAGagataagaaaagaaaacatacAGTCATGGAGTTATTTCATACACATTCTAGAAAACGGACAAAAAATGAAGGagataaattatcaaaaaaacAAGAGGTAGCAATACATGAAAATGGAGATGTACcagaaaaaattgatttagaTGGTACTTTGTTTGGTCCTTGTTATGATCCTGGAACGGATCTGTTACGAGGATTTGACACTAATATAtctaaaatgaaaagttttcCAAAAAAGAGCAAGAAAGATATCCCAAGAACTGATATAAGTCAGGAAGATGATGTAGGACCCGAGTGGATAGATGGAGAACCACAAGGAACTGAATCTTATATAGTAGATGGAAATGATGGGCCTCGTCGCTCAATAATCGTTGCAGATAAAAGATTACCGCCTGGATGGCAAAAACATTTTACGCAAAGAAAAGCCGGTACATCTGCTGGAAAATGGGATGTCTTATTTCTTCATAAATCAAGTGGAAAGAAGTTTAGATCACGAAACGATATCAAAGTATTTCTGGAAAACCAAGGGCAGTTTGATTTTGATcctgagaaatttgatttttgtattcatcggaaaaagaaaaactacgggcaaaaaataaaacaacctATTACCATGGATGTACCAAAAAAGATAAAAACTTTATTACCTAAAACAAAAGCACCAGCATCGGAAGATTCGTTGCTGGTTTCAACAAGTACACCAGTTACAACTTTAGTATCTACATCAACAACATCTATCACAGATGGTGCCGTTTTCATTGGTGGACTTCGCGTAGAAATGGAGGACAGTGCTTACAAATGTCCAAAGCAGGGatgtaataaaacatttcgTAAAGAGAATCTTTTACAAATGCATATAAAACATTATCATccagaatattcaaaatttttgggATCTACGCCAAATGTTGCAGATTTAGCGTACGCACGAACAATTGGGGAATCCGTTGAAGATATTATTccgaaaaaatcaaataatttactaGACAAATGTAATAAACTTGGAAAGAAAAAACCTGTTCATGAGAAAGCATTATATACTGCACCATCATCTCTAACGACTTTTGTTCAATCTACGTCAccaaaagtaattttatcaaCGACATCAGACATAGAAGATGAAATAGATCAAGTAGAAAAAAGTAATGATGTACCAGCAGAAGACATTAAATCAGAAAGAATGTCTCCAATTTCGAGCTATAGCGTCGATATGgatgatgaaattgaaaagaaacgagatGCTTCTGCAATGTCCCCTGGAACATTATTTGACATGAAAATCAAAGAAGAAAGAACACAAACTGGCATTAAAACTCTTCTTCCTGTAAGACCGGCAGTGTCTTCAGAGATACAAAGGATTGATAGACCAAAATCTTTAGATgaagttattaatattgatagaATGAAGGGTCAACGAAAACGACAATTGTCAGAATACAGTTCTGATGGATTAAATAGGAATAAACGACGTCAAGGTATTCAAGAACTAGATGAATATGGTGATTTAGATGATAGTGCTTTGGATACCGATGAACCGACGACGCTTACATATAGATATAGTCGCAGAAAATCAGATTCCAGAAGTGATGAAAATAGCCAGAGTAgTCAACTAAATGATTCTCGCGTTGAAAAAGATGATACTTTGAAAGGGGATATTGCTAAAAAAGATACTAATGATAGGGaagaaACTGAAGGTGTTATGATGATGATTAATGGAGAAATGATAAAGGTTGAACAACTGCGTagagaagaaataataaattgtacctGTGGATTTATGGAAGAAGATGGTTTAATGATACAGTGCGACCTTTGTTTATGTTGGCAACACGGGCATTGCAATGCaatagaaagagagaaagatgTACCcgaaaaatatgtttgttatatttgtCAAAATCCATATCGACAACGGCCATCTAAAAAGTATTTTCACGATCAAGATTGGGTGAAGGAGGGAAAGCTGCCAATGTTATCTGATCGAACAAAAAATCagtatcgaataaataaaagaacggCTATGTTGAAACGTTCTTATGATTTAGTTGCGTCTCTTTTACAAATACAGCAAGTTTTACATAGTTTAAgagtaaaaattaatgtagcTCAaaaaaaggATCATCCAAAGTTGTACCTTTGGgcgaaaaattgggaaaaagTGGAAGTACCAAAACCAGATATAACACCAGTACCAATAATGGAAGTTACCAAATCAGGAAAGGATGATTCAGATAGTACAATTGAAACTTCTCGTCGAGTTGAAGTGAAGACAGAAATAAAGTTTACTTTAAAGGATAATcacgatgaaaaattaatagctTCAGACTCAGAGttgatgaaaattttagagGAAGATAACCCAACTTCGGACGATTCCAAAGTTTCCTGCAAGAAAGAAGATCTgacgaatgaaaataaaagtcaTATTCTTCTTGATGCACTCACAAAAAGTGCTGTTGCTgaagaaaagtataaaaattcagcGACTTCGGAAATGAAAACGGATACAGatttattaaacaatCAAAACATTGTATCAGAAAATGATATACCTATACCAGCTGCTTCAGAAAACAGCATGcatgaagaattgaataaacaCGAAACATCGACACCGATACAGCCTTTTATTCCACAACCTGAAGCGCCAATTGACCCAGGGGAATGCCGAATGCGATTGTTAGaacatattgaacattttcaaaatcatataGATGCAAGATTAACATTTATTGAGGCACAAGTTTGTgcatTAGAAACTATGGATCCTGAAGATGTATCTAGTCCAGATATTCAACCACGAACAAAACAAACAGTTCAAATGCTGCTTCGAGATTTAAATACAGTACGAAAGTTAGCTGCtctatgttaa
Protein Sequence
MKRRRIARSRGKGIPPLRMMKMARKCCVRSCEVDVQDARAKGLPLHRFPKDSNLRSKWLASGGFETTFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSISPLVSEAKTQKIDTCKETCSSEPALLADSSNELDSKEILDNGYKNSNVKEKNSIKQEKVPAQQEVNENSEVQVNTVAVQLGIVESDIAMKDIQKNLIIKEELKNVKMEDEKVFEKSDELKPKILNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTQSNEETWDLPSSEEKMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTVKSSKMTKITPTSTKQFNQTEEYIGSKQERRDKKRKHTVMELFHTHSRKRTKNEGDKLSKKQEVAIHENGDVPEKIDLDGTLFGPCYDPGTDLLRGFDTNISKMKSFPKKSKKDIPRTDISQEDDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIKVFLENQGQFDFDPEKFDFCIHRKKKNYGQKIKQPITMDVPKKIKTLLPKTKAPASEDSLLVSTSTPVTTLVSTSTTSITDGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLDKCNKLGKKKPVHEKALYTAPSSLTTFVQSTSPKVILSTTSDIEDEIDQVEKSNDVPAEDIKSERMSPISSYSVDMDDEIEKKRDASAMSPGTLFDMKIKEERTQTGIKTLLPVRPAVSSEIQRIDRPKSLDEVINIDRMKGQRKRQLSEYSSDGLNRNKRRQGIQELDEYGDLDDSALDTDEPTTLTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDTLKGDIAKKDTNDREETEGVMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCYICQNPYRQRPSKKYFHDQDWVKEGKLPMLSDRTKNQYRINKRTAMLKRSYDLVASLLQIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPDITPVPIMEVTKSGKDDSDSTIETSRRVEVKTEIKFTLKDNHDEKLIASDSELMKILEEDNPTSDDSKVSCKKEDLTNENKSHILLDALTKSAVAEEKYKNSATSEMKTDTDLLNNQNIVSENDIPIPAASENSMHEELNKHETSTPIQPFIPQPEAPIDPGECRMRLLEHIEHFQNHIDARLTFIEAQVCALETMDPEDVSSPDIQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00963847;
90% Identity
iTF_01122433;
80% Identity
iTF_00961875;