Most005404.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Melikaiella ostensackeni
Gene Symbol
znf423
Assembly
GCA_032362435.1
Location
JAUMHM010000005.1:27396848-27436570[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 1.8e-05 0.006 19.2 1.3 1 23 134 156 134 156 0.98
2 19 0.6 1.9e+02 5.0 3.9 1 23 162 184 162 184 0.97
3 19 1.4e-06 0.00044 22.7 4.1 1 23 190 212 190 212 0.99
4 19 0.00015 0.05 16.3 0.4 1 23 218 240 218 240 0.98
5 19 0.0001 0.033 16.8 0.6 1 23 389 412 389 412 0.96
6 19 0.052 17 8.3 0.0 2 23 422 444 421 444 0.89
7 19 0.26 84 6.1 0.1 3 23 504 524 503 524 0.97
8 19 0.049 16 8.4 0.2 2 23 537 558 536 558 0.97
9 19 0.0019 0.63 12.8 0.7 1 23 567 590 567 590 0.93
10 19 4.7 1.5e+03 2.2 0.2 1 23 595 618 595 618 0.91
11 19 0.8 2.6e+02 4.6 2.0 2 23 691 712 691 712 0.96
12 19 0.003 0.96 12.2 0.3 1 23 717 740 717 741 0.94
13 19 6.3e-05 0.02 17.5 1.0 2 23 842 864 841 864 0.96
14 19 0.052 17 8.3 1.0 1 23 873 896 873 896 0.93
15 19 0.016 5.2 9.9 0.1 2 23 1088 1110 1088 1110 0.92
16 19 0.21 67 6.4 0.4 1 23 1116 1139 1116 1139 0.95
17 19 5.6 1.8e+03 1.9 0.4 2 23 1152 1173 1151 1173 0.92
18 19 0.24 77 6.2 0.1 2 23 1182 1204 1181 1204 0.94
19 19 0.03 9.6 9.1 3.1 1 23 1211 1234 1211 1234 0.95

Sequence Information

Coding Sequence
ATGGCCTTTTTGGCCTCTGGTGTAAATAGGGGACCAGGAGACGGGAATTTTGATAAGcaaggaatttttgaatctAATGATCTCGAGTGCAGTGAAGTTGCGTTCTGGGAAATACCGGATGTGAGAAACACGTGGACGAGGGCGAATGAAATAGAACATAGAGTCACGTCTCACGGTGGAAATGACTCGGCTAGTTGGCCGTTTCCTCATTTGTTAAGAGCAAaggCCCTGGGAACTGGAAGTTCATCTTGGCACAGTGAAGACGGAAGACCGACTTCCCGAAAAGGGGAAGAAACGCCATCTTCTTGTGCAACTCCTACTTCGGCCAGTTTCCCCTCGGAACCGGAGGTGGAAACTGATATTGGTACAACAGCCGATGGAAATAATCCTGCCGCTCCATATCCTTGCCAATTTTGTGACCGAATGTTCCCCAGGTTGAGTTACCTCAAAAAGCATGAACAGagcCATGGTGACCAAATGCCCTACAGGTGCAGTTGGTGTGCAAgattatttaaacataaaaggAGCAGAGATCGTCACGTGAAGTTACACACTGGCGACAGGAGATATCGATGCTCGCATTGCGAGGCTGCATTCTCTAGAAGtgACCATCTGAAGATTCACATGAAAACACACGACACCCAGAAGCCTTTCCAATGCACATCATGTTCCCGAGGCTACAACACAGCAGCAGCTTTAACATCCCACATGCAATCCCACAAAAGACACCAAAACTCCCAAGGATCAAAACTAGAAATGGATTTCGGACGCAGGAGTGTTTCCTCCCACAGTACAGCATCACCCCCTATTCCCAATTCACCTTCTCCAAGTCTAAATTTAACCCTCAGCCACAAAAACTCCCTAAAGTCCCAGGCTAGTGCCTCTAACACTCCAATCCTATCATCACCTTTAAAACTAGCCTGCATGTACTGTACTCGAGATTCCTTCACCAGCATGCAACAACTTCAACTTCACGTTCACACAATGCATCAAGCAATCCTAAGTGGAGAAAATCTGATGCCATCACCAAGCCAAACCCTAGAACTATCAAACTCCAGAGAAAAATATGATCGTCAAGAAAGAACCCTAAGAGAAGATCGTTTATACGACAAAAAGTTTCCAGAAGTTAGATCCCTGGAAGAAAAAGAGATCATCGATTCAGGATTTTCCTGTGGACAATGTACCATGAAGTTTTCTTCTTCAAGTTCTCTCAGAGACCATCTGATTTCCATTCATCGAGCAAATGCTTTTGGATCGTTGATGGTGTGCCCCATCTGTGGTATTCCCTGTTCTTCAGCAGCAGCCTACGCAGAACACTACGTTCTCCAACATTGTGAAAATAGAGGAATATCTGCAGAAGGTCGAGAATATGGTGACCCAAAGATAAACGGATCCTACGACACTAAGGAAGCAAGAACAGCAAAAATATCGAAGGATTTAAACTCGGAACCAGCTGATTTAACCAAACACTCGAAAATTGCCGAAAATTATTCAGCAGGGACTTTATTATGTGGACAATGTGGTGCtgctttgaaagatttcgagtCTTTTAGAGAACACCTCGCAAGGCATCTCCAAGCTGATCAGAGGAATGAAGTTCCAAGGAATCAGTGTCCAACATGTGAAGCTTCCTTCCAGGAGAGAGAGGATATGATGGTCCATTTGACAAAGCATTTTTTGGGACAAGTCACCAAGGAATACGCCTGCAGTGCCTGCAAGAAATTTTACCCCCATCCTGATCTTCTTCAGAGGCATCTTCTTGATTCCCATGCCCATCATCTTTACAGATGTGCCCTTTGCAGGGACACTTTTGACTCTCGGGTAGCAATCCAGGTTCATTTTGCTGTAAAACATAGTCAAGAGTGTCGGATTTACAGATGCAATGTCTGTTCTGGGtcgaacaatgaaaattcttctggGAATGCTCCTGGGGAAAACAGAAACTTCTTCAGGAGCGAAGCTGAAATGGCGAACCATGTTAGAACTGTCCATGCTCCTCCGTCCATTGTGAATGAAAGTCCTCTTCCTAGGAGTCCTGCATCGACTCCAGGGATGACGAACACAAACCCAAGATGTGTTTTTTGTGGAGTTTGCTGTTCCTCTGACTTGGAGCTTCAACTCCACTTGGCAAGCCACTCCACAAGTTTGTACCGATGTCCCATTTGTCGGGAAAGATTTGCTGTTGAGTTTCTATTAGACAGACATATTGCTCAAGTTCATCATGCTAATGATCATCCCAGCACTCCAAGAAGTCATACTAGGGAAAACGGAAGGATACATCGACCTTCGAGATCTCAGGAAGATTCTAGGTCCCTGAAACGAGGAAAGTCCCCTGCCTCTAGTAACAACAATTCTTTGAACCAAAGGGACAATAACAACAAGAGACCGAATTTCGGAACTGCCCAACAATGTGAGCTTTGTGAAAGAGGAGAATTCGTCAACGATGCTGAACTGCAAGCTCACAAAAAATTGGCTCACACTCCTGCAAAGGTTCCAGGAAAATCTTTATCAGCTCTGAGCATGACTTGTGCATATTGTGGGGAGGTTTGTCGGTCTAGAAGTGAATTAGAATCGCATACGAGAATACAACATGCAACTAATGATCATGGAGGTCGTCACAAGTGCAACATCTGTGATGAAGTTTGTCCCTCTGGAGCAACTTTGGCTGAACATAAACTACAGAAACATTGTAAGATCCAGCTGAGTGATGTTTGCATTGTCTGCAGAGGAAATTTGTCTTCTGAGTCTCACTTTTTGGAACATGTTCAGAGACATAGTTTGGAAAGTGTTGATCCCCAACAAAGGCTGGATAGTTCAGTGCCTCATCTTCCTGCACCTTGCGTGGTTTGTAGACAAACTTTGATCAGTGATTTGGAGTGTAGGCTTCATGCGAAGCATCATCTTAGGTCCAGTGGTGCTTCCCAGAGGTCTGACTCGAGTCCGAGTCCTAATCAGAAGACTCAGAGTCATAGTTGCTGTCTCTGTCTCAGGGAGTTTAATGGAGAGGAGTTTGTTAGTTTGCCTTCAAATCATTCCAGTAGTGGTAGTCAAACATTGAGAGTTTGTAGAGCTTGTTATGTGAGGCATTCACAAGGTCTTCCGATTTTGAACTCACCTTATGAACATGCGAGGACTAGTCAGAGTGAATTGTGGATGAAGGAGTCACATTGGGATGGATCCAGGGAGAGGTGGGACggtgaaaagaattttaagatggAAGAGAGGATTTCCAATGATGGAGGAGGATCGAGTGATGGAAGAAGATGTGAAGAATGTGGAGTGAAGTTTGAAGATCCAGAGGAGACTGAGAAGCATAGGATTGCTGAACATGAGAAGCCTGGGACTTATACTTGTATTCAGTGCCAGatgtCCTTTCCCACCGAAGCTAAAATACAGCAGCACGTTAAAAAAGAACATCTTGAGTCTTCTGGGAAAACTTCTTTGGAAGCTTTGCGTTGTCACCTCTGTTTATTTGATGCCAATAGCCCTCTGCAACTTCAGAGTCATCTTATAGAACACACTTTTGCGGGATGTACTGCCCTCAGTTGTTACATTTGTCAGGCCCTATTTACAGCACCAATTGGACTTCagaatcacATGCTTCAGCAACATGGCCTTGGTGCTCGACCTTATGATTGCAGCCACTGTGGATTGAAGTTTTTCTTCAGAGCTGAACTTGATCATCACGTGTCTGTTTTTCATTCTACACgggaaaatatttcttctccTCAAGACAGAAAAATACAGAATGAATTTCCAGATTCTGAAGAACGTACTGAAGCTTCTGACAAAATGACCATCAAAGAAGAAATTCGACAAAGTGAAGATGAAGATATCTATGTAGATATTAACGATAAATCCGTAAAACAGAAAAAAGGTTCGCGAAAGCTTGAGTCTGAATCTGAAGAAATCCGAACCGAACTTGCCAAGTCTGAATga
Protein Sequence
MAFLASGVNRGPGDGNFDKQGIFESNDLECSEVAFWEIPDVRNTWTRANEIEHRVTSHGGNDSASWPFPHLLRAKALGTGSSSWHSEDGRPTSRKGEETPSSCATPTSASFPSEPEVETDIGTTADGNNPAAPYPCQFCDRMFPRLSYLKKHEQSHGDQMPYRCSWCARLFKHKRSRDRHVKLHTGDRRYRCSHCEAAFSRSDHLKIHMKTHDTQKPFQCTSCSRGYNTAAALTSHMQSHKRHQNSQGSKLEMDFGRRSVSSHSTASPPIPNSPSPSLNLTLSHKNSLKSQASASNTPILSSPLKLACMYCTRDSFTSMQQLQLHVHTMHQAILSGENLMPSPSQTLELSNSREKYDRQERTLREDRLYDKKFPEVRSLEEKEIIDSGFSCGQCTMKFSSSSSLRDHLISIHRANAFGSLMVCPICGIPCSSAAAYAEHYVLQHCENRGISAEGREYGDPKINGSYDTKEARTAKISKDLNSEPADLTKHSKIAENYSAGTLLCGQCGAALKDFESFREHLARHLQADQRNEVPRNQCPTCEASFQEREDMMVHLTKHFLGQVTKEYACSACKKFYPHPDLLQRHLLDSHAHHLYRCALCRDTFDSRVAIQVHFAVKHSQECRIYRCNVCSGSNNENSSGNAPGENRNFFRSEAEMANHVRTVHAPPSIVNESPLPRSPASTPGMTNTNPRCVFCGVCCSSDLELQLHLASHSTSLYRCPICRERFAVEFLLDRHIAQVHHANDHPSTPRSHTRENGRIHRPSRSQEDSRSLKRGKSPASSNNNSLNQRDNNNKRPNFGTAQQCELCERGEFVNDAELQAHKKLAHTPAKVPGKSLSALSMTCAYCGEVCRSRSELESHTRIQHATNDHGGRHKCNICDEVCPSGATLAEHKLQKHCKIQLSDVCIVCRGNLSSESHFLEHVQRHSLESVDPQQRLDSSVPHLPAPCVVCRQTLISDLECRLHAKHHLRSSGASQRSDSSPSPNQKTQSHSCCLCLREFNGEEFVSLPSNHSSSGSQTLRVCRACYVRHSQGLPILNSPYEHARTSQSELWMKESHWDGSRERWDGEKNFKMEERISNDGGGSSDGRRCEECGVKFEDPEETEKHRIAEHEKPGTYTCIQCQMSFPTEAKIQQHVKKEHLESSGKTSLEALRCHLCLFDANSPLQLQSHLIEHTFAGCTALSCYICQALFTAPIGLQNHMLQQHGLGARPYDCSHCGLKFFFRAELDHHVSVFHSTRENISSPQDRKIQNEFPDSEERTEASDKMTIKEEIRQSEDEDIYVDINDKSVKQKKGSRKLESESEEIRTELAKSE