Basic Information

Gene Symbol
-
Assembly
GCA_902806685.1
Location
NC:10212723-10239506[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 7.9e-05 0.003 17.4 1.5 1 23 410 432 410 432 0.96
2 18 0.0063 0.24 11.5 0.6 1 20 438 457 438 460 0.94
3 18 1.9e-05 0.00074 19.4 5.6 1 23 479 501 479 501 0.98
4 18 1.5e-05 0.00057 19.7 5.6 1 23 507 529 507 529 0.99
5 18 3.2e-05 0.0012 18.7 5.3 1 23 535 557 535 557 0.97
6 18 1e-05 0.0004 20.2 7.3 1 23 563 585 563 585 0.97
7 18 6.5e-07 2.5e-05 24.0 2.9 1 23 591 613 591 613 0.97
8 18 9.3e-05 0.0036 17.2 6.7 1 23 619 641 619 641 0.97
9 18 9.2e-05 0.0035 17.2 6.5 1 23 647 669 647 669 0.97
10 18 4.4e-07 1.7e-05 24.5 1.9 1 23 675 697 675 697 0.98
11 18 8.8e-06 0.00034 20.4 7.7 1 23 703 725 703 725 0.98
12 18 3.2e-06 0.00012 21.8 7.6 1 23 731 753 731 753 0.98
13 18 0.0001 0.0039 17.1 7.3 1 23 759 781 759 781 0.97
14 18 4.2e-06 0.00016 21.4 5.9 1 23 787 809 787 809 0.98
15 18 5.2e-05 0.002 18.0 7.8 1 23 815 837 815 837 0.97
16 18 8.4e-06 0.00032 20.5 5.1 1 23 843 865 843 865 0.96
17 18 0.00067 0.026 14.5 0.3 1 23 872 894 872 894 0.96
18 18 0.013 0.51 10.4 5.3 1 23 902 924 902 924 0.99

Sequence Information

Coding Sequence
ATGAATCAGGATCACCACAGTATGAATACGGGTGGTGGCCAACCTCCAAGCAATTCGGAGTCTCAGAATGCGAGGGTGCAGTCTGCTCAGCAACAACAGCAAGCTAACTTGACTCCTACAACATCTGCTACTGACTTGCGAGTCAACTCTGCAGCTGTGAACGTTGCTTTGTCGAGCGTAGCCAAGTATTGGGTGTTTACAAACCTCTTTCCCGGTCCATTGCCGCAGGTTTCCGTTTACGGTTTACCCAGTACAAGAATTGAAAATGGGAAACCAGTTCAGGACCTTGGTCAGGCGCATGCTAGCATATTGAATGGAGATCCCAACATCATACTGGGGCACACAGGGCAGCCGCAGGTCACAGTGTCTGCAGCGGGCCAACAAATTCCTGTATCACAGATAATTGCTTCACAGGCTGCACAAGGACATGATGCTCTGGTGGGCCACAGCCAACAGCAGGAGGCATCAGCCAGCGCCCAACTTGTAGCGAGCCAAGCTTCCCAGCAGGTACCCAATAATCGGGTCGACTTTGTACAACACCATAACATTGATATGGGTCACCATTCCCAACAACACATGATGCAGCAACAGCTGATGGCAGCAGCTCGGCCAGAACATGCTAACCAACagATCCAACTCACGGTGAGCGAGGATGGCATAGTGACGGTGGTGGAGCCGGGCGGAGGGAAACTGGTAGATAAGGAGGAACTGCACGAGGCGATAAAGATGCCCTCGGACCACACTCTCACTGTGCATCAGTTGCAACAGATCGTTGGACATCATCAGGTCATAGACAGTGTAGTCCGCATCGAGCAAGCCACAGGCGAGCCGGCCAATATACTGGTGACGCAGAATCCAGACGGCACGACGTCCATAGAGACGAGTGCAGTCGACCCCCTACTCGTCAAAGACGAGAAGAGCGTCGCCAAAATAGAGTCGGCCCAGTTTGCTATACCCGCTGACATTAAGGACATCAAGGGAATTGATTTAAAGAGCGCAATGGGTATGGAAGGGGCAGTGGTAAAGATATCAACTGGCTCTGAACACGATCTTCACACCATGTACAAGGTAAACGTGGAAGACCTGTCCCAACTGCTCGCTTACCATGAAGTGTTCGGGAAACTCAGCACTGAAGGACAGCCGCAAGCCAAGATGATAAACGAGGTGGAAGTGGATGTGCCAGGCACAAGCGCGGCGATGTCGGAAGCTGAATCCTCCCCTGGACACCACGCGTGCGACATCTGTGGGAAGATATTCCAGTTCCGATACCAGCTTATTGTTCACAGGCGGTATCACGGCGAGAACAAGCCATACACATGTCAAGTCTGCGGATCTGCATTTGCCAATGCTGTTGAACTATCCAAACATGGAAAATGTCACCTTGCGGGTGACCCAGCCGAGCGGCAAGCGAAGAGGCTGGCTCAAGACAAACCGTACGCCTGTACCACATGTCACAAGACGTTCTCGCGCAAGGAGCATCTTGACAACCACGTTCGCAGTCACACTGGAGAAACTCCTTATAGGTGCCAGTACTGCTCAAAGACGTTCACCCGAAAGGAGCACATGGTGAACCACGTGCGCAAGCACACGGGTGAGACGCCGCATCGCTGCGAGATCTGCAAGAAGAGCTTCACGCGCAAGGAGCACTTCATGAACCACGTCATGTGGCACACGGGTGAAACGCCGCACCATTGTCAAATATGCGGGAAGAAGTATACTAGGAAGGAGCATTTAGTGAACCATATGCGATCCCATACAAACGATACGCCGTTCCGATGCGAACTGTGTGGCAAGTCCTTCACGAGGAAGGAACACTTCACCAATCACATATTGTGGCATACGGGTGAAACCCCACACCGCTGCGACTTCTGTTCGAAGACGTTCACTCGCAAGGAACATTTACTAAACCACGTGCGTCAACACACTGGAGAATCGCCGCATCGATGCAACTTCTGCTCGAAGTCCTTCACGCGCCGCGAACACCTTGTGAACCATGTACGGCAGCACACTGGGGAGACGCCGTTCCAGTGTGGATACTGCCCTAAAGCATTTACTAGAAAGGATCATCTTGTAAACCACGTCCGTCAACACACCGGGGAGTCCCCTCACAAGTGTTCATACTGCACGAAGTCGTTCACGCGAAAGGAGCATCTGACCAATCACGTGCGCCAACACACTGGGGAGTCCCCGCACCGGTGTACATACTGTTCTAAATCCTTCACAAGGAAGGAACATCTTACTAATCATATTAGGCAACACACTGGGGAGACGCCATTCAAATGCACCTTCTGTTCAAAGTCCTTCTCAAGAAAGGAACACCTCACTAACCACGTCCACCTCCACACGGGGGAAACTCCACACAAATGTCCTTTCTGCACCAAGACATTCTCTAGAAGGGAGCATTTGACCAATCATGTTCGGATACACACTGGCGAATCGCCGCATCGGTGTGAGTTTTGCCAAAAGACGTTCACTCGCAAAGAGCACCTCACGAACCACTTGAAGCAACACACAGGCGACGCGCCGCACGCGTGTAAAGTGTGCTCCAAGAATTTCACGAGGAAGGAGCATCTCGTTCAACATATGAGGTCCCACAGTTGCGGCGATCGTCCGTTTAGTTGCGGCGAATGTGGAAAATCGTTCCCCTTGAAAGGCAACCTGCTGTTTCACGAGCGGTCACACAAAGCCGGCAACACGAAACAGTTCCGCTGCGAAATCTGCTCCAAGGAGTTCATGTGCAAAGGTCACTTGGTATCCCACCGACGAACGCACACGGAAACGGATGTGCCTGTGGCCAATACGGAACCGGTGGCCGAAAACGAGAATTGCGGTGACTACGCCAAGTGCGAGAAAGACAACACCGAGATTCCCGAGAGGAAACATGATATCAGGGCAACATCAGACAACAGAAATATTGACAACACGGGAACACAAACTCAGCTGAATACAGTCATGCAAATAACAAGTCAGCAACCGGTGCGAGCGGGCGCAGTGACGAGCGCAGCGAGCGTCGCATCCGGCACATTCACACACACGCCCAGCGCACAGCATCACGCGGGCGCCACCATCGCGCACCATCCCGTCACTGTGAACTACTAG
Protein Sequence
MNQDHHSMNTGGGQPPSNSESQNARVQSAQQQQQANLTPTTSATDLRVNSAAVNVALSSVAKYWVFTNLFPGPLPQVSVYGLPSTRIENGKPVQDLGQAHASILNGDPNIILGHTGQPQVTVSAAGQQIPVSQIIASQAAQGHDALVGHSQQQEASASAQLVASQASQQVPNNRVDFVQHHNIDMGHHSQQHMMQQQLMAAARPEHANQQIQLTVSEDGIVTVVEPGGGKLVDKEELHEAIKMPSDHTLTVHQLQQIVGHHQVIDSVVRIEQATGEPANILVTQNPDGTTSIETSAVDPLLVKDEKSVAKIESAQFAIPADIKDIKGIDLKSAMGMEGAVVKISTGSEHDLHTMYKVNVEDLSQLLAYHEVFGKLSTEGQPQAKMINEVEVDVPGTSAAMSEAESSPGHHACDICGKIFQFRYQLIVHRRYHGENKPYTCQVCGSAFANAVELSKHGKCHLAGDPAERQAKRLAQDKPYACTTCHKTFSRKEHLDNHVRSHTGETPYRCQYCSKTFTRKEHMVNHVRKHTGETPHRCEICKKSFTRKEHFMNHVMWHTGETPHHCQICGKKYTRKEHLVNHMRSHTNDTPFRCELCGKSFTRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCNFCSKSFTRREHLVNHVRQHTGETPFQCGYCPKAFTRKDHLVNHVRQHTGESPHKCSYCTKSFTRKEHLTNHVRQHTGESPHRCTYCSKSFTRKEHLTNHIRQHTGETPFKCTFCSKSFSRKEHLTNHVHLHTGETPHKCPFCTKTFSRREHLTNHVRIHTGESPHRCEFCQKTFTRKEHLTNHLKQHTGDAPHACKVCSKNFTRKEHLVQHMRSHSCGDRPFSCGECGKSFPLKGNLLFHERSHKAGNTKQFRCEICSKEFMCKGHLVSHRRTHTETDVPVANTEPVAENENCGDYAKCEKDNTEIPERKHDIRATSDNRNIDNTGTQTQLNTVMQITSQQPVRAGAVTSAASVASGTFTHTPSAQHHAGATIAHHPVTVNY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-