Basic Information

Gene Symbol
MBD2
Assembly
GCA_018904285.1
Location
JBAMBO010004042.1:991195-997286[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.1e-23 1.1e-19 70.4 0.0 1 74 9 83 9 86 0.91
2 2 6.4e-06 0.023 15.0 0.0 27 76 174 234 151 235 0.90

Sequence Information

Coding Sequence
ATGCAAATGAATCCGAGTTTGACAATCGAACGCAAACGCGTCGATTGCAGTGCTCTGCCCAAGGGTTGGCAACGCGAGGAAGTACGCAAATCGGCCAAtagcaacaacagcaataacaacaacaacaaagtggaTGTCTTCTATTACAGTCCAACAGGCAAAAGAATTGAAAGCAAGCCACAATTAGCTCGTCAATTGGGCAGCGAAATGTTTGACATTGGCAACTTTGATTTTCAAACTGGCAAAATGCTGCAACACCAGCAGCTTCAGCGTCAATTGCCCTCACCCTCGATATCGCTATATCGCTGCAGTGTGATGCCCACGCTGCCCAGTGGAGGAGCAGCGGGCAATCTTAAACGAAAGTATAACAGAGCCCAGGCCCAGGGCAGTAACAATGGCAGCATCAATACACAAACAATGGCATCAGCAGGAGCGTCGGCGAACGCAGCAACCACACCAGTTGGAGCAACTGCCACCTCATCTAGCAATCTACGCCATCAGCAACAATTTGAACTCAGTCGCGCCCTACGCACAGATGTCTCCCTGGTGCCACCCATACGACAAACTGCCTCAATTTTTAAGCAACCTGTTACGGCAATTCGAAATCACAATCAGGATTCCGGCAAAGTTAAACACGATGCCAAACATGGTGCCCAAGAGAAACCGAAACAACTATTCTGGGAAAAGAGGCTGGAACGGTTACGAGCCTGCCACGACAATGGCGAAGAGTTAGATGACATATCACTGCCCAAAACCATACGCACCGTTGGCCCCAATGTTAATGAACAGACTGTCCTGCAATCGGTGGCCACCGCCCTGCATATGCTCAATGCCGGTGTGCATGGCCAGAGCAGCACTAAGGCTGAGTTAACCAAGAATGCGATGGCATTCATGAATCCTGAACAGCCATTGATGCATGCGGTGATCATTTCAGAGGATGATATACGCAAGCAGGAGGACCGTGTGAGTGTGGCGCGACGAAAGCTACAGGATGCGCTGAAAACATGA
Protein Sequence
MQMNPSLTIERKRVDCSALPKGWQREEVRKSANSNNSNNNNNKVDVFYYSPTGKRIESKPQLARQLGSEMFDIGNFDFQTGKMLQHQQLQRQLPSPSISLYRCSVMPTLPSGGAAGNLKRKYNRAQAQGSNNGSINTQTMASAGASANAATTPVGATATSSSNLRHQQQFELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHNQDSGKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2