Basic Information

Gene Symbol
MBD2
Assembly
GCA_018903935.1
Location
JAEIFP010002295.1:632750-634441[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.9e-23 1.8e-19 69.2 0.0 1 74 9 84 9 87 0.92
2 2 4.1e-06 0.015 14.9 0.0 27 76 176 236 155 237 0.90

Sequence Information

Coding Sequence
ATGCAATTGAACCCAAGCGTAACGATTGAACGCAAACGCGTCGATTGCACTGCTTTGCCAAAGGGATGGCAACGTGAAGAAGTACGCAAATCGGCGAACAGCAGCAGCGCACCCAACAATAATAACAACAAAGTGGATGTCTTTTACTACAGTCCCACAGGCAAGCGAATTGAAAGCAAACCGCAATTAGCCCGTCAGTTGGGCAGCGAAATGTTTGATATTGGAAATTTTGATTTCCAATCGGGCAAAATGCTGCAGCAGCAGCAACGTTATTTGCCGTCGCCATCTATATCGCTGTACCGTTGCAGTGTCATGCCTCCACTACCCAGTGGAGGAGGATCTGCCAATGCACTGAAACGAAAATATTCTAGAGGCCAGCCACAGGGCCCACAAGGAATGGATAAGGATGTGGTCTTCGAAAAGGATTTGATTGGCCAAGCACCAGGCTGTACTGTCATCACTACATCTAACTCTTCTTCAAATCTTCGCCAGCAGCAGCAACAACAACAGCATTTGGAACTCAGTCGTGCTCTACGCACAGATGTCTCCCTCGTGCCGCCTATACGGCAGACTGCCTCTATTTTCAAGCAACCCGTGACGGCAATTAGGAATCATAACCAGGAATCCAACAAAGTCAAACACGATGCCAAACACGGCGCACAGGAGAAACCCAAGCAATTGTTTTGGGAGAAACGTTTAGAACGATTGCGTGCTTGTCATGACAATGGCGAAGAGCTGGATGACATTACATTGCCCAAAACAATACGCACTGTGGGCCCCAACGTTAATGAACAGACCGTTCTACAATCAGTGGCCACTGCCCTGCATATGCTCAACGCCGGCGTTCACGGACAGAGCTCAACCAAGGCTGAGTTAACCAAAAACGCCATGGCCTTTATGAATCCCGAGCAACCCTTGATGCATGCGGTAATCATCTCCGAGGATGATATACGAAAGCAGGAGGATCGGGTTAGTGTGGCAAGACGAAAGCTGCAAGATGCTCTAAAAACATGA
Protein Sequence
MQLNPSVTIERKRVDCTALPKGWQREEVRKSANSSSAPNNNNNKVDVFYYSPTGKRIESKPQLARQLGSEMFDIGNFDFQSGKMLQQQQRYLPSPSISLYRCSVMPPLPSGGGSANALKRKYSRGQPQGPQGMDKDVVFEKDLIGQAPGCTVITTSNSSSNLRQQQQQQQHLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHNQESNKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00918126;
90% Identity
iTF_00555843;
80% Identity
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