Dema013403.1
Basic Information
- Insect
- Drosophila emarginata
- Gene Symbol
- MBD2
- Assembly
- GCA_037075365.1
- Location
- JBAMCD010000221.1:27302046-27303775[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 9e-23 2.4e-19 69.1 0.0 1 76 9 86 9 87 0.93 2 2 7.9e-06 0.021 14.8 0.0 26 76 175 236 162 237 0.90
Sequence Information
- Coding Sequence
- ATGCAGATGAATCCGAGCGTAACAATTGAACGCAAACGCGTCGATTGCAGCGTTCTGCCAAAGGGTTGGCAGCGGGAGGAAGTACGGAAGTcggccaacagcagcagcgcagcaaataataataataacaaagtGGACGTCTTTTACTACAGTCCCACAGGCAAGCGAATTGAAAACAAACCGCAACTAGCCCGTCAATTGGGCAGCGAAATGTTTGACATTGGAAACTTTGATTTCCAATCAGGCAAAATggtccagcagcagcagcgttCATTGCCATCCCCATCTATATCGCTGTATCGCTGCAGTGTGATGCCTCCACTACCCAGTGGAGGATCTGCCAATGCGCTGAAGCGTAAATATAGTAGAGCCCAAGCACTGGGACTACAAGGAATGGAAAAGGAATTTTTCGGCCAGGGAAACGAGAAGGATGTGTTTGGCCAAGGATCGGGCTGTACAGTCGTCGCAGGCTCTAACTCCTCTATCAATATgcgccaacagcagcaacagcatttgGAACTCAGTCGGGCTCTTCGCACAGATGTTTCCCTAGTGCCGCCCATAAGGCAAACTGCCTCTATTTTCAAGCAGCCCGTGACAGCCATCAGGAATCACAACCAAGAACCTAACAAAGTTAAACATGATGCCAAGCATGGAGCACAGGAGAAACCAAAGCAATTGTTTTGGGAAAAACGATTGGAACGATTGCGTGCTTGTCACGACAATGGTGAAGAATTGGATGATATTACACTGCCCAAAACCATACGCACTGTGGGACCCAATGTCAATGAGCAGACGGTTCTACAATCAGTGGCCACCGCCCTGCATATGCTTAATGCCGGCGTACATGGTCAAAGCTCCACCAAGGCTGAGTTAACGAAGAACGCCATGGCCTTCATGAATCCCGAACAACCCTTGATGCATGCGGTAATCATTTCCGAGGATGATATACGAAAGCAAGAGGATCGGGTTAGTGTGGCAAGGCGAAAATTGCAAGATGCTCTAAAAACATGA
- Protein Sequence
- MQMNPSVTIERKRVDCSVLPKGWQREEVRKSANSSSAANNNNNKVDVFYYSPTGKRIENKPQLARQLGSEMFDIGNFDFQSGKMVQQQQRSLPSPSISLYRCSVMPPLPSGGSANALKRKYSRAQALGLQGMEKEFFGQGNEKDVFGQGSGCTVVAGSNSSINMRQQQQQHLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHNQEPNKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00918126;
- 90% Identity
- iTF_00555843;
- 80% Identity
- -