Basic Information

Insect: Lasioglossum zephyrum
Gene Symbol: MBD-R2
Assembly: GCA_028455615.1
Location: CM052331.1:7416268-7428375[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.9e-17 5.6e-14 51.7 0.2 6 69 546 609 541 617 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.9e-17	5.6e-14	51.7	0.2	6	69	546	609	541	617	0.91

Sequence Information

Coding Sequence: ATGAAGCGGCGGCGTATAACGCGGTCGCGTGGTAAAGGAATACCGCCTGTGGGGGCGATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAAGCTGATGTGCGGGAAGCGCGTGCTAAAGGTTTTCCACTTCATAAATTCCCGAAGGAAATTGGCTTGAGAAGCAGGTGGTTGGCCAGTGGTGGTTTCGAGGCGAGTTTTAAACCTTCGCCGGGTCAAATTGTCTGCCACAGACATTTTAAACGAGCTGATTACGAAGCCGCCAGGGGACAGAAATTACTTCTACGAAAAGGCAGTGTTCCATCGGTTTTTGCGGATTATGATAATCATCCAGATCCTGTCATCATGTCTGTTAAATCGTCAACTTCTTATGCACAAGAGGATTTGGATCTCATTAACTCTGAAATATTAAATTTAGAACAATCTATATCTCCGTTATTATCCGAAGCAAGAACACCTAAATCAGACAGCTGCGGAGAAACATGTTCGTCTAGACCTGAATCATCAGCCGATTCTCTTAATATGACAGATTCAACGGAAGTAGTTGACAACGGATTTAAAACAATACCTGTGAAAAGCGAAACTATGGCTCCTGCGAAACAAGAGATCAACGAGCATTTAGAATTAGAGGTAAACACTATGGCTGCCCAATTAGGAATTGTAGAATCGGATATGACAATAAAGAATATCCAGAAAGACTTAATTATTAAGGAGGAGCTAAAGAATATTAAAATAGACGATGATAAAGCATTCGACAAACCAGAAGAATTAAAAGCAAAAGTGTTGAATCGGGATGGATTGAAATTTTTTCCTGGAGCTAAATTGGAAGCGAAAGATTTCAATGACAAGTGGTATTCTGCTAAAGTTGTTGAAACCGATTGGGACGAAAGGGAAGTTTTAATACATTTTGACAAATGGAGTTCAAGATTCGACGAATGGATACCTATGGATAGCTCTAGATTACGTGTGTTACAAACACAGTCAAACGAACAAACTTGGGACCTGCCATCTCTGGAAACGAAAATGAAAGACTTTTCAGTTGGAGAAAGGATACTTGCTACGTGGGCCGACGGGAGAAAATATCCAGCGAAAGTAAATGCAGTGTTAGGAAATGATAGATACGATGTTCTCTTTGACGATGGATACGCAAAAACCGTTAAATCATCGAAAATGACGAAAATCGCTACAACATCCACAAAGCAAATCGTTCAAAGCGAAGACTATATAGGAAGTAAACAAGAAAGAAGGGATAAGAAGCGAAAGCACATAGTGATGGAACTGTTCCATACACATTCTAGAAAGCGATCATCCAAAAATGAAGCAGACAAGTTGTTGAAAAAGGAAAGTTTGGTAGTAAATGGAAGTGGAGGAGGAGATTGTCTGCCTGAAAGTAAAATTGATTTAGATGGTACTTTGTTTGGACCTTGTTACGATCCTGGGACAGATTTATTACGAGGATTTGATACTAACATATCAAAAACTAGACCATACGCAAAGAGAAACAAGAAAGAAATGTTTAAGAATGATGTGGACCAGGAAGAAGATGTAGGGCCTGAATGGGTAGATGGAGAACCACAAGGAGTTGAATCATACATTGTAGATGGAAATGATGGACCACGTCGTTCAATAATAGTGGCAGATAAAAGACTACCACCTGGTTGGCAGAAACATTTCACTCAAAGAAAAGCAGGCACATCTGCTGGAAAATGGGATGTCTTGTTTCTTCATAAATCAAGCGGAAAGAAATTTCGATCAAGAAATGATATTAGAGCATTCATGGAAAATCAGGGGCAATCTGATTTCGATCCAGAAAAGTTTGACTTTTGTATTCATCGAAAAAAGAAAAGCCATGGACCGAAAATGAAGCAAGAAGTTGTTACAGATGCGCCAAAGAAAATTAAGACTTTATTGCCGAAAACGAAAGCAATACCGTTAGCTGATACATTACTTATACCTGCAACTTCACCAGTTGCAACGATAGTGTCTACGCCAACAACATCTATCGCCGATGGTGCTGTTTTTATTGGGGGACTTCGCGTAGAAATGGAGGACAGCGCTTACAAATGTCCGAAGCAAGGGTGCAATAAAACTTTTAGAAAGGAAAATCTTTTGCAAATGCACATCAAACATTATCACCCGGAATATTCAAAATTTTTGGGATCAACTCCAAACGTTGCAGACTTAGCTTACGCAAGAACAATTGGGGAATCGATTGAAGATATTATTCCTAGAAAATCAAATAATGTGTTAGAAAAATATAGTAAATTAGGGAAGAAAAAAACTGTTCAGGATAAACCTTTGTACGCGATGTCACCGACAGCATCAAATTCTGCTCAACCCACGTCGCCAACGATAGCGATGTCAACAGTCTCCGAAGTGGAGGACGAAATCGATCAACTAGAACAGTCTAATGAAACGCAAGCTGAAGATGTTAAAGTAGAAAAAATGTCTCCGATTTCCAGTCGTAGCGTAGATATGGACGATGAAACTGAGAAAAAACGAGAGGAGACATGTGCGATGTCACCGGGAACACTGTTTGATCTAAAGGTCAGGGAAGAGAAAACACCAAGTGGTATTAAAACTCTTCTTCCAGTGAGGCCAACTACGTCATCAGAAGTACAGAGAATTGATAGATCGAAATCTTTAGATGAAGGTATCCATATTGACAAAAATAAGGGCCAAAGGAAACGGCAATTATCAGAGTACAGCTCTGATGTTCCGAGCAGGGGTAAAAGACGTCACGGTATGCAAGAAATTACGGACGAGAGAGAATACGGAGATTTGGATGAAAGCGCAGTGGACGCTGAAGGTCCGACCACACTGATGTATAGATATAGCCGTCGAAAATCGGATTCAAGAAGTGATGAGAATAGCCAAAGTAGTCAACTAAACGATTCTCATCTCGAAAAAGCTGATCCCCTGAAAGGGGATGTTACTAAAAGAGATACAAATATTGATGGTGAAGAAAATGAAGGAGTTATGATGATGATTAATGGTGAAATGATAAAAGTGGAACAACTTCGCAGAGAAGAAATAATAAATTGTACGTGTGGATACATGGAAGAAGATGGTTTAATGATACAATGCGACCTTTGTTTATGTTGGCAACATGGTCATTGCAACGCGATCGAGAAGGAAAAGGACGTGCCTGAAAAATACATTTGTTACATTTGTCAGAATCCGTATCGACAACGCCCGTCAAAGAAGTATATCCATGATCAAGATTGGATAAAGGAGGGCAAATTGCCAACATTATCGAACAGAACAAAGAATCAATATTCACTTAATCAGAGAACAGCTATGTTGAAACGTTCTTACGATTTAGTCGCTGCACTTTTGCAGATACAGCAAGTGCTGCACAGTTTAAGAATAAAAATTAATGTAGCTCAAAAGAAAGATCATCCAAAGTTGTATCTGTGGGCGAAGAATTGGGACAAGATAGAAATACAAAAGCCAGATATAACACCTGTACCAATCATAGAAATTACAAAAGCATCGAACGATGCTGCAGACATTGTAGACGACGTGTCCCGTCGAATTGAAGTCAAGATGGAAACGAAATTTACTTTGAAGGAGGATCCTGATGAAAAATCGATAGCCTCGGATTCGGAGTTGATGAAAATTTTGGAAGAAGATAATACGATGGCAGAAGAAGCTAAACTTGCTTGCAAAAAAGAAGATTCGGCGAATCAGAATAAAAGTCACATCCTTCTTGATGCGCTTACAAAAAGCCCTAGTCCTGAAGGAAAATACAAGACTTTAACAAATTCGGATACGAAAACCGGTAATAAGGATCTACTATCGAATCAAACAGCCGAAGATGATATATCCACGTCAACAATGCCAACACACGAGATGCAGGATGAAAATGGACATGATTTATCAACACCATTACAACCTTTTATACCCCAACCGGAAGCACCTATAGATCCAGGAGAATGTCGAATGCGGTTATTGGAACATATTGATCATTTTCAAAATCACGTAGATGCTAAATTAACATCTATCGAGGCGCAAGTTTGTGCTTTAGAAGCTATGGATCCGGAAGATATAATACCTAGTCAAGATGTTCAGCCCCGAACTAAACAAACAATCCAAATGCTTCTCCGAGATTTAAACACAGTGCGAAAATTAGCAGCATTATGTTAG
Protein Sequence: MKRRRITRSRGKGIPPVGAMRMARKCCVRSCEADVREARAKGFPLHKFPKEIGLRSRWLASGGFEASFKPSPGQIVCHRHFKRADYEAARGQKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSISPLLSEARTPKSDSCGETCSSRPESSADSLNMTDSTEVVDNGFKTIPVKSETMAPAKQEINEHLELEVNTMAAQLGIVESDMTIKNIQKDLIIKEELKNIKIDDDKAFDKPEELKAKVLNRDGLKFFPGAKLEAKDFNDKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTQSNEQTWDLPSLETKMKDFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKTVKSSKMTKIATTSTKQIVQSEDYIGSKQERRDKKRKHIVMELFHTHSRKRSSKNEADKLLKKESLVVNGSGGGDCLPESKIDLDGTLFGPCYDPGTDLLRGFDTNISKTRPYAKRNKKEMFKNDVDQEEDVGPEWVDGEPQGVESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIRAFMENQGQSDFDPEKFDFCIHRKKKSHGPKMKQEVVTDAPKKIKTLLPKTKAIPLADTLLIPATSPVATIVSTPTTSIADGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIEDIIPRKSNNVLEKYSKLGKKKTVQDKPLYAMSPTASNSAQPTSPTIAMSTVSEVEDEIDQLEQSNETQAEDVKVEKMSPISSRSVDMDDETEKKREETCAMSPGTLFDLKVREEKTPSGIKTLLPVRPTTSSEVQRIDRSKSLDEGIHIDKNKGQRKRQLSEYSSDVPSRGKRRHGMQEITDEREYGDLDESAVDAEGPTTLMYRYSRRKSDSRSDENSQSSQLNDSHLEKADPLKGDVTKRDTNIDGEENEGVMMMINGEMIKVEQLRREEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYICYICQNPYRQRPSKKYIHDQDWIKEGKLPTLSNRTKNQYSLNQRTAMLKRSYDLVAALLQIQQVLHSLRIKINVAQKKDHPKLYLWAKNWDKIEIQKPDITPVPIIEITKASNDAADIVDDVSRRIEVKMETKFTLKEDPDEKSIASDSELMKILEEDNTMAEEAKLACKKEDSANQNKSHILLDALTKSPSPEGKYKTLTNSDTKTGNKDLLSNQTAEDDISTSTMPTHEMQDENGHDLSTPLQPFIPQPEAPIDPGECRMRLLEHIDHFQNHVDAKLTSIEAQVCALEAMDPEDIIPSQDVQPRTKQTIQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00866063; iTF_00866008; iTF_00866752; iTF_00862563; iTF_00862616; iTF_00183332; iTF_00183285; iTF_00863270; iTF_00860391; iTF_00861140; iTF_00863318; iTF_00860445; iTF_00861215; iTF_00762600; iTF_00763280; iTF_00762551; iTF_00763228; iTF_00625545; iTF_00625494; iTF_00864018; iTF_00863953; iTF_00864690; iTF_00864637; iTF_00861875; iTF_00183989; iTF_00183947; iTF_00966069; iTF_00966029; iTF_00024668; iTF_00024617; iTF_00086340; iTF_00084551; iTF_00086279; iTF_00088872; iTF_00088823; iTF_00087160; iTF_00087224; iTF_00084603; iTF_00085438; iTF_00085376; iTF_00360902; iTF_00360263; iTF_00360213; iTF_00360954; iTF_00087998; iTF_00088053;
90% Identity: iTF_00762600;
80% Identity: iTF_00866752;