Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_013123115.1
Location
WUUM01000026.1:1021276-1028979[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.7 1.1e+04 -4.0 0.0 45 62 402 419 401 431 0.74
2 2 2.8e-17 1.1e-13 50.4 0.3 6 69 544 607 539 615 0.90

Sequence Information

Coding Sequence
atgaagcggcggCGTATACCGCGGTCGCGTGGTAAAAGAATACCGCCTGTGGGGGCGATGAGAATGGCGCGCAAATGTTGTGTGCGTAGCTGCGAGGCTGATGTACAAGAAGCGCGTGCTAAGGGGTTACCGCTTCATAAATTTCCAAAGGATATTGCTCTAAGGAGCAGGTGGTTGACCAGTGGTGGATTTGAAGCGAGTTTCAAACCTTCACCGGGTCAGGTTGTCTGCCATAGACATTTTAAACGAGCTGATTACGAAGCCGCTAAGGGGCATAAGTTACTTCTACGTAAAGGCAGTGTTCCATCGGTTTTTGCAGATTATGATAATCATCCGGATCCCGTGATTATGTCTGTGAAATCATCAACTTCGTATGCACAGGAAGATCTAGATCTtattaattctgaaattttaaacttagAACAATCTATTTTGCCGCAATTATCTGAAGCAAGAACACCAAAATCAGGTAGCTGTGAAGAAATATGCTCTTCTCAACCGGATTCGTCTGCTGCCATTCTCAACTTGATAGACCCAACAGAAATAGTTGATAACGACTGCAAAGCTTTAACTGCAAAAGTAGAAACTATGTCTTccataaagaaagaaatacatgaaaatttagaaatggAAGTAAATACTATGGCTGTTCAATTAGGAATTGTAGAATCAGATGTAGCAATGAAACATATACACAAAGAATTGGCTATTAAAGAAGAGttaaaacatattaaaatagaagatGAGAAAACATTTGGTAAATCAGAAGACTTAAAGGCAAAGATATTAAATCGTGATGGATTAACGTTTTTTCCTGGAGCTAAATTAGAAGCAAaagatttcaatgaaaaatgGTATTCGGCTAAAGTAGTTGAAACTGATTGGGAAGAAAGAGAAGTCTTGATACATTTTGACAAGTGGAGCTCAAGATTTGACGAATGGATACCTATGGATAGTTCTAGATTACGTGTGTTACAATCACAGTCAAAcgaaCAAACTTGGGATCTACCATCTCCggaaacgaaaatgaaaGGTTTTTCAGTGGGAGAAAGGATTCTCGCTACGTGGGCCGACGGGAGAAAATATCCAGCGAAAGTAAATGCGGTGTTAGGAAATGataGATACGATGTACTGTTTGACGATGGATACACAAAAACTGTTAAATCgtcaaaaatgacaaaaatcgCTGCAACATCCACAAAGcaACTGTCTCAAACTGAAGAGTACATAGGAAGTAAACAAGAAAGAAGAGATAAGAAACGGAAGCATATAGTAATGGAGTTGTTTCATACACACTCTCGTAAACGGTTAAAAAATGAAGCagataaattaacaaaaaaggaaGGAGTCGTAATGAATGAAAATGGTGATTGctttcaagaaaataaaattgatttagaTGGTACTTTGTTTGGTCCATGTTATGATCCAGGCACAGATTTGTTGCGAGGATTTGATACTAACGTATCAAAAGTGAAAACTTATGtaaaaaagaataagaaagaaatatctaataaatatgaaatagaCCAGGAGGAAGATGTAGGACCTGAATGGATAGATGGAGAGCCTCAGGGCACTGAATCTTATATAGTAGATGGAAATGATGGACCACGTCGCTCAATAATAGTCGCGGATAAAAGATTACCGCCTGGATGGCAGAAACATTTTACTCAAAGAAAAGCTGGTACATCCGCGGGCAAATGGGATGTCTTATTTCTCCATAAATCAAGCGGGAAGAAGTTCAGGTCGCGAAATGATATCAGGGCTTTCATGGAAAATCAGGGACAATTTGACTTCGATccagaaaaatttgatttttgtattCATCGAAAAAAGAGAAGCTATGGgcataaattaaaacaagAAATTGTCACAGATGTACCCAAAAAAATTAAGACCTTATTACCGAAAACAAAGACAACACCAGTAATGGATTCGTTGCTTATATCAGCAAATACATCAGTTACAACCGTAGTACCTGCACCAACAACGTCAATTACGGATGGCGctGTTTTTATTGGCGGGTTACGTGTAGAAATGGAGGATAGTGCTTACAAATGTCCGAAACAAGGATGTAATAAAACATTTAGGAAGGAAAATCTTTTACAAATGCACATAAAACATTATCATCcggaatattcaaaatttttgggATCTACTCCAAATGTTGCGGACTTGGCTTACGCGAGAACAATTGGAGAATCTATCGATGATATTATTCCgagaaaatcaaataattcattagaaaaatataataaattagcAAAGAAAAAGTCTATTCAAGATAAACCACTTTATGCTGCATCGCTATCAGTAACAAGTTCTACTCAACCTGCATCTCCAATAGTTTTGCCAACAGTCTCAGAAGTAGAGGACGAATTGGACCAAATAGAGCAATGTAACGAAGTACAAGCAGAAGAGGTTAAGATAGAAAGAATTTCTCCCGTTTCTAGTCATAGTATAGATATGGATgatgaaaatgagaaaaaacgAGAAGATTCGTGTGCAATGTCACCTGGAACATTATTTGATATGAAAATTAGAGAAGAAAAAACGCAAAGTGGTATTAAAACTCTTCTTCCAGTGAGGCCGACTACGTCGTCAGAAATACAGAGAATCGATAGATCGAAATCGTTGGATGAGAGTATTCACATCGATAGAATGAAAGGTCAAAGAAAACGACAATTATCAGAGTATAGTTCCGACGTTCCAAGTAGGGGTAAAAGGCGACACGGTATGCAAGACATTACAGATGATTATGGCGATCTAGACGACAGTGCTATGGATACTGAAGGACCGACAACGCTTGTGTATAGATATAGTCGTCGAAAATCAGATTCAAGAAGCGATGAAAATAGTCAAAGTAGTCAACTAAACGATTCTCATCTTGAAAAAGATGATCCCTCGAAAGGGGAGATTACTAAAAGAGATACAAATAATGATGGGGAAgaaaatgaagGAATTATGATGATGATTAACGGTGAAATGATAAAGGTGGAACAACTACGTagagaagaaataataaattgtaccTGTGGATTTATGGAAGAAGACGGCTTAATGATACAATGTGATCTTTGTCTGTGTTGGCAACATGGTCATTGTAATGCaatagagaaagaaaaagatgttcccgaaaaatatgtttgttaTATTTGTCGGAATCCATATCGACAGCGACCATCCAAAATGTATTTTCACGATCAAGATTGGATGAAGGAGGGCAAACTACCCACATTACCTAACCGaacaaaaaatcaatataCAATTAATCAAAGGACAGCTATGTTAAAGCGTTCTTATGATTTAGTTGCAGCTCTCTTGCAGATACAACAAGTACTGCACAGTTTGAGAATAAAAGTTAACGTAGCTCAAAAAAAAGATCATCCAAAATTATATCTTTGGGCAAAAAACTGGGAGAAGATGGAAATACAAAAACCAGACGTAACGCCAATACCAATTATAGAAATCACGAAAGTAACGAACGATTCTGTGGACACCGTAACTGATGCATCTCGTAGAGTTGAAGTAAAGACGGAAACCAAGTTTACCGTAAAAGATGATCATGATGAAAAATCAATAGCTTCGGATtcagaattaatgaaaattttggaaGAAGATAATACAACTAACGATGAATCTAAAGTTCTCTCTAAGAAAGAAGATTCAACGAATCAAAATAAGAGTCACATTCTTCTCAATGCTCTCACAAAAAGTACTACTTCAGGGGAGAAGTGTAACACTTCAGTAACCTCGGACGAGAAAGTAGATACAGATTTATTATCAAATCAAACGGATGTGTCCGATAACGATGTATCTGAAACAACTATATCAGCGAATCAAATCCACGAAGAATTAAATGAGCACGAAATATCAACATTACAGCCTTTTATACCGCAACCAGAAGCACCAATTGATCCAGGAGAATGTCGAATGCGATTATTAGAACATATAGAGCATTTTCAAAATCACATAGACGCAAAATTAACATCCATTGAAGCACAAGTTTGCGCATTAGAAGCCATGGATCCTGAAGATGTTGTACCTATCCCAGATGTTCAGCCTCGAACTAAACAAACAGTTCAAATGCTTCTTCGAGATTTAAATATAGTTCGAAAATTAGCTGCTTTGTGTTAA
Protein Sequence
MKRRRIPRSRGKRIPPVGAMRMARKCCVRSCEADVQEARAKGLPLHKFPKDIALRSRWLTSGGFEASFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSILPQLSEARTPKSGSCEEICSSQPDSSAAILNLIDPTEIVDNDCKALTAKVETMSSIKKEIHENLEMEVNTMAVQLGIVESDVAMKHIHKELAIKEELKHIKIEDEKTFGKSEDLKAKILNRDGLTFFPGAKLEAKDFNEKWYSAKVVETDWEEREVLIHFDKWSSRFDEWIPMDSSRLRVLQSQSNEQTWDLPSPETKMKGFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYTKTVKSSKMTKIAATSTKQLSQTEEYIGSKQERRDKKRKHIVMELFHTHSRKRLKNEADKLTKKEGVVMNENGDCFQENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKVKTYVKKNKKEISNKYEIDQEEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIRAFMENQGQFDFDPEKFDFCIHRKKRSYGHKLKQEIVTDVPKKIKTLLPKTKTTPVMDSLLISANTSVTTVVPAPTTSITDGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIDDIIPRKSNNSLEKYNKLAKKKSIQDKPLYAASLSVTSSTQPASPIVLPTVSEVEDELDQIEQCNEVQAEEVKIERISPVSSHSIDMDDENEKKREDSCAMSPGTLFDMKIREEKTQSGIKTLLPVRPTTSSEIQRIDRSKSLDESIHIDRMKGQRKRQLSEYSSDVPSRGKRRHGMQDITDDYGDLDDSAMDTEGPTTLVYRYSRRKSDSRSDENSQSSQLNDSHLEKDDPSKGEITKRDTNNDGEENEGIMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCYICRNPYRQRPSKMYFHDQDWMKEGKLPTLPNRTKNQYTINQRTAMLKRSYDLVAALLQIQQVLHSLRIKVNVAQKKDHPKLYLWAKNWEKMEIQKPDVTPIPIIEITKVTNDSVDTVTDASRRVEVKTETKFTVKDDHDEKSIASDSELMKILEEDNTTNDESKVLSKKEDSTNQNKSHILLNALTKSTTSGEKCNTSVTSDEKVDTDLLSNQTDVSDNDVSETTISANQIHEELNEHEISTLQPFIPQPEAPIDPGECRMRLLEHIEHFQNHIDAKLTSIEAQVCALEAMDPEDVVPIPDVQPRTKQTVQMLLRDLNIVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00866702;
80% Identity
iTF_00360954;