Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963932275.1
Location
OZ010728.1:49226310-49235695[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.3 9.5e+03 -2.6 0.1 44 60 401 417 399 436 0.76
2 2 1.7e-16 1.3e-12 48.2 0.3 6 69 543 606 538 614 0.90

Sequence Information

Coding Sequence
ATGAAGCGGCGGCGTACAGCGCGGTCGCGTGGTAAAGGAATACCGCCTGTGGGGGCGATGGGAATGGCGCGCAAATGTTGCGTGCGTAGCTGCGAGGTTGATGTGCAAGAAGCTCGTGCTAAAGGCTTGCCGCTTCACAAGTTTCCGAAGGATATTGGCCTGAGAAACAAGTGGTTAACCAGCGGTGGATTCGAAGGGAACTTTAAGCCTTCGCCGGGTCAGGTTGTCTGCCACAGACATTTTAAACGAGCAGATTACGAAGCCGCCAAGGGGCACAAGTTACTTCTACGTAAAGGCAGTGTTCCGTCGGTCTTTGCGGACTATGATACTCATCCAGATCCCGTGATTATGTCCGTGAAGTCGTCTACTTCCTACGCGCAAGAGGATTTGGATCTGATTAATTCCGAGATTCTGAACCTGGAGCAATCTATCTCGCCGCTACTGTCCGAAGCAAGAACGCCCAAGTCGGATAGTTGCGGAGAAACATGTTCCCTCCGACCAGGCTCGGCCGACCCTGCGAACCGCCCGGACTGCGCGCGATTAGTCGACAACGGTCGCAAAGCCGCGGCTCCGAACGTAGAGGCTGCCGCTGCTCCGATGAAAGAGGAAATAACTGAAGATTCGGAGAGCCAAGTAAATACGATGGCGGTGCAATTGGGAATCGTAGAGTCGGACCCGGCGATGAAGAATATACAGAAAGAGTTGGTTATCAAGGAGGAGCTGAAGAATATTAAACTGGAAGACGAGAAGGCGTTCGATAAGCCGGACGATTCGAAGACGAGAATGTTAAATCGAGACGGGCTGAAATTCTTTCCCGGCGCCAAATTAGAGGCGAAAGATTTCAACGAGAAATGGTACTCCGCTAAGGTGGTGGAGACCGATTGGGAGGAAAGGGAAGTGTTGATACACTTCGACAAGTGGAGCTCGAGATTCGACGAGTGGATACCCATGGATAGCTCTAGATTGCGTGTATTACAAGCGCAGTCAACCGAACAAACTTGGGACCTACCATCTCCGGAAACGAAAATGAAAGACTTTTCGGTAGGGGAGAGGATACTCGCTACGTGGGCCGACGGGAGGAAATACCCGGCCAAAGTAAAGGCGGTGTTAGGAAATGACAGATATGACGTGCTCTTTGACGATGGATACGCAAAGACTGTTAAATCGTCGAAGATGACGAAAATCGCTACGACGTCCGCGAAGCAATCCACCCAAATTGAAGAGTATATAGGAAGTAAACAAGAGAGAAGGGATAAGAAGCGAAAACATACGGTGATGGAGTTGTTTCATACGCACTCTAGAAAACGGTCGAAGAATGAAGCCGACAAACTGACCAAAAAGGACGGGCCTGCGGTTAACGAGAATGGGGAATGCTTTTCGGAAAATAAGATCGATTTAGATGGCACTTTGTTTGGACCGTGCTACGATCCAGGCACAGATTTGCTACGAGGCTTCGATACGAACGTATCAAAGATGAAATTTTGTAGCAAGAAAACCAGGAAAGAAACGTCTAAGAATGATATAGATCAGGAAGAAGATGTAGGGCCCGAGTGGGTAGATGGAGAACCTCAAGGAACCGAATCGTATATAGTGGACGGAAACGATGGACCACGTCGATCCATAATAGTGGCGGATAAAAGATTACCGCCGGGGTGGCAGAAACATTTTACTCAGAGAAAAGCTGGCACATCTGCTGGCAAATGGGATGTTCTGTTTCTTCATAAATCGAGCGGAAAGAAGTTCAGATCCAGGAACGATATTAGATCGTTTATGGAAACACAAGGGCAATTTGACTTTGATCCCGAGAAATTTGATTTTTGTATTCACCGAAAGAAGAAAAGCcatgtacaaaaaataaaacaagATGTTGTGGATGCGCCGAAAAAAATCAAGACTCTATTGCCTAAAACAAAGACAACATCCGTAGCAGATAATTTGTTGCTTACGCCGACAAGCGCAGCAGTTGCAACCGTCGCGTCTACGCCAACATCTGTTACAGATGGTGCTGTTTTCATCGGCGGACTCCGCGTAGAAATGGAGGACAGTGCTTATAAGTGTCCGAAGCCAGGATGTAATAAAACATTTAGGAAGGAAAATCTTTTACAAATGCATATAAAACATTATCATCCAGAATATTCCAAGTTTCTGGGATCCACGCCGAATGTTGCAGACTTAGCTTATGCGAGAACGATTGGAGAATCTGTCGAGGACATTATTCCTAGAAAGTCGAATAatttgttggaaaaatataacaAATTTGGGAAGAAGAAGTCTGTTCAAGATAAAGCATTATACATCGCGTCACCATTAGCAACATGTTCTACCCAACAACCCACATCACCCACAGTAATATTGCCAACAGTCTCGGAAGTGGAAGACGAGATGGATCAGGTGGAGAAGTGCAACGACACGCAAACAGAGGATATTAAAATGGAAAGAATGTCTCCGATTTCTAGTCATAGTATAGATATGGATGAAAATGAAGGTGAGAAAAAGCGGGAAGAAGCATGTGCAATGTCACCCGGAACATTATTTGATATAAAGATCAGAGAAGAAAAAACACAAAGTGGTATCAAAACTCTTCTCCCGGTAAGACCAAGTTCGTCGGAAGTACAAAGGATTGATAGATCGAAATCGTTGGACGAAGGCATTCATATCGACAAAATGAAGGGTCAACGGAAGCGACAATTATCGGAATACAGTTCTGACGTCCCAAGTAGGGGTAAACGGCGACACGGCGCGCAAGAACTTGCCGATGAATATGGCGATATAGACGACAGTGCTGTGGATGCCGAAGGACCTATTGCTCTGATGTACAGATATAGCCGTAGAAAATCAGATTCAAGAAGTGACGAGAACAGTCAAAGTAGTCAACTAAACGATTCTCGCCTTGAAAAAGGCGATTCCTTGAAAGAGGATATCGCTAAAAGAGGTACTAATAATGATGGGGAAGaaaatgaaggAGTTATGATGATGATTAATGGTGAAATGATAAAGGTGGAACAACTACGCAGGgaagaaataataaattgtaCTTGTGGATTCATGGAAGAAGATGGCTTGATGATACAGTGCGACCTTTGTTTGTGTTGGCAACATGGCCATTGTAATGCAATCGAAAGAGAAAAAGATGTGCCCGAAAAATATGTTTGCTTCATTTGCCAAAATCCGTATCGACAAAGACAGTCGAAAAAATATTACAACGATCAAGATTGGATCAAAGAAGGCAAATTGCCAACGTTGCCCAATCGAATGAAAAATCAGTATATAGTTAATCGAAGAACAGCTATGCTGAAGCGTTCTTACGATTTAGTGGCCGCTCTGTTACAGATACAACATGTCCTGCACAGCTTACGAGTGAAGATCAACGTAGCTCAAAAAAAAGATCATCCGAAGTTATATCTTTGGGCGAAAAATTGGGAAAAGATAGAAATACAAAAGCCGGACGTAACGCCAGTGCCGGTTGTAGAAATTACAACAAATACAGCGAAAGATACTGCAAACACCGTAGCTGATGCATCCCGCCGAGTGGAATTAAAGACGGAAACGAAATTCACTTTAAGAGACGATCACGACGAAAAATCAATAGCTTCCGATTCAGAGTTAATGAAAATTTTGGAAGAAGACAACACAACTGCGGAGGACACGAAAATTATTTGTAAGAAAGAAGATGCAGTAAATCAGAATAAAAGCCATATTCTTCTCGATGCTCTTACAAAAAGTAGTGCTACGGACGAAAAATATAAGAATTTGATAGCATCGAGCGTGAAAACAGACGCAGATACATTGTCGAATGAAACGGCTGTGCTTGAAAATGATATATCTGCGACAACCGTATCAGCAATTCCAATGCACGGCGAATTAAACGAGCATGGAATATCAACGCCGGTACAGCCTTTTATACCACAACCAGAAGCACCAATTGATCCAGGAGAATGTCGAATGCGGTTATTAGAACACATTGAACATTTTCAAAACCATATAGATGCAAGATTAACATCCATCGAGGCACAAGTTTGTGCTTTGGAAGCGATGGATCCGGAAGATGTACCTAGTCCAGATGTCCAACCTCGGACTAAACAAACGGTTCAAATGCTTCTTCGGGATTTAAACACAGTACGAAAATTAGCTGCTTTGTGTTGA
Protein Sequence
MKRRRTARSRGKGIPPVGAMGMARKCCVRSCEVDVQEARAKGLPLHKFPKDIGLRNKWLTSGGFEGNFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDTHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSISPLLSEARTPKSDSCGETCSLRPGSADPANRPDCARLVDNGRKAAAPNVEAAAAPMKEEITEDSESQVNTMAVQLGIVESDPAMKNIQKELVIKEELKNIKLEDEKAFDKPDDSKTRMLNRDGLKFFPGAKLEAKDFNEKWYSAKVVETDWEEREVLIHFDKWSSRFDEWIPMDSSRLRVLQAQSTEQTWDLPSPETKMKDFSVGERILATWADGRKYPAKVKAVLGNDRYDVLFDDGYAKTVKSSKMTKIATTSAKQSTQIEEYIGSKQERRDKKRKHTVMELFHTHSRKRSKNEADKLTKKDGPAVNENGECFSENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKMKFCSKKTRKETSKNDIDQEEDVGPEWVDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSRNDIRSFMETQGQFDFDPEKFDFCIHRKKKSHVQKIKQDVVDAPKKIKTLLPKTKTTSVADNLLLTPTSAAVATVASTPTSVTDGAVFIGGLRVEMEDSAYKCPKPGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPRKSNNLLEKYNKFGKKKSVQDKALYIASPLATCSTQQPTSPTVILPTVSEVEDEMDQVEKCNDTQTEDIKMERMSPISSHSIDMDENEGEKKREEACAMSPGTLFDIKIREEKTQSGIKTLLPVRPSSSEVQRIDRSKSLDEGIHIDKMKGQRKRQLSEYSSDVPSRGKRRHGAQELADEYGDIDDSAVDAEGPIALMYRYSRRKSDSRSDENSQSSQLNDSRLEKGDSLKEDIAKRGTNNDGEENEGVMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCFICQNPYRQRQSKKYYNDQDWIKEGKLPTLPNRMKNQYIVNRRTAMLKRSYDLVAALLQIQHVLHSLRVKINVAQKKDHPKLYLWAKNWEKIEIQKPDVTPVPVVEITTNTAKDTANTVADASRRVELKTETKFTLRDDHDEKSIASDSELMKILEEDNTTAEDTKIICKKEDAVNQNKSHILLDALTKSSATDEKYKNLIASSVKTDADTLSNETAVLENDISATTVSAIPMHGELNEHGISTPVQPFIPQPEAPIDPGECRMRLLEHIEHFQNHIDARLTSIEAQVCALEAMDPEDVPSPDVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2