Hhis009611.2


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Hirtodrosophila histrioides
Gene Symbol
Runx1_1
Assembly
GCA_037075165.1
Location
JBAMCL010000444.1:6668462-6688429[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.5e-73 1.2e-69 232.0 0.0 3 129 98 224 96 224 0.98
2 2 2.9 1e+04 -3.7 0.0 68 91 594 618 589 621 0.74

Sequence Information

Coding Sequence
atgcatttgacaACCACAAGCAGTAATTCAACGGCAtccaatgccaacaacaacaacaataacaacaacaacaacactacaaacaccaacaacaacaacaactcgagcagcagcaacaacaataacaacaacacaagcaaCACAAAtggcaccaacaacaacaacaacaactcgagcagcaacagcaacaacaacagcaccgaACAGAACACACCCCCCACACCCGCCCAGCTGCTAAATGAGGCATACACGAAGATGACCTCGGACATTCTCGCCGAACGCACCCTGGGCGACTTCCTCACCGAGCACCCCGGCGAGCTAATAAGGACAAGCAGCCCGCTCTTCGTCTGCACCGTCCTGCCGCCACACTGGCGCTCCAACAAGACGCTGCCTGTGGCCTTCAAGGTCGTCTCCCTGGGGGACATCATGGACGGCACCATGGTCACCGTGCGAGCGGGCAACGATGAGAACTACTGCGCCGAGCTGCGCAACTGTACCGCCGTGATGAAGAACCAGGTGGCCAAGTTCAATGATCTTCGCTTCGTGGGACGCAGCGGTCGAGGGAAGAGCTTCACATTAACCATCACCGTGTCAACGAATCCACCACATATAGCTACCTACAACAAGGCGATCAAAGTAACCGTCGATGGGCCCCGGGAACCCCGCTCCAAGACCATGCTATCCCTTttagggcaacaacaacaatttcactTCGCCTTTGGCCAACGACCGTTCCACTTCTCCACGGATCCCCTCTCCGGCTTCCGCATGCCGCCCATTGGCAACTGTCAGAGTGCCAGCAACACACATTGGGGCTACGGATCGGCGGCTTCTGCCTATTCACCGTACTTGGCCAGCAGCGGACTGTCCTCCTGCACCACGCCCACCTCGGCGCAGTTCAACAATCCAGCCCTGGGCTTTACCTGCTCCTCCAACGATCAGAGCAACAATCAGGACTTCGGAGGCGCCACCAATCGCGATTGCGTACCGATGCTTCCAGACTCCACGGCTAGCGACCTGGATCAGCATCTCAGCAGTCTGGTGGGCTCCACCAGTGGCCAGATGTCGCATCATAGCTTGCTGGGCGCCAGTGGCCAGACGTCCATCACATCGACGGTGAATGGGGCCAGCGGCGGGAGCGGGGCCACCGCTGGCAGCGCATCCGGAGCCGGCAGCGGAGCCGTCGCCAACTCTATACTGGTGCCGCGGTATCACACGAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAAAACGGGCCGCGCAGCCTGAGCGACAGCTCCCAGGCGGAGTCGCCAGTGCAGGAGGATCTGCTGTCCACCAATACGCCCAATctgggcagcggcagcggcggcggggCGACCAACGGGGGTGCCGCCAATGGCGGTGCTGGCAGTGCCGCTGGCGCTGGCAGCGGTGCCTCGGCGGGCGCCTCGGCTGGCGCCGGCAATCCGGCCATGCTGGGCGCCAATCAGAACTTTCCGGGCATTGTCAACCAGGCCCAGCACGCCTCCGCCTCTGCTTATGGCGGCGGtgtcggcgtcggcgttggcgtcggcaGTGGCCATGGCAGCGGCGCCGGCGCCACAGCCGCCGGCTGCAATGGTTCCCTGTATCCGGTGCTGCCCGCCAGTCTGCTCTACTCGCAGCTGTATACCGCTGCCAATCAGTCGGCACACGGATTCCACTCACATACGCTGCCGGCGCACGCCTCCCCCAACTCCTCCGTGCACGGGGAGCTGCAGAGCGTGATGGATCACATTAGCAATGTGGGCGTGAGGCAGCAGCATAACATTATGGCCGGCGGGGGCGTGGCGCATCCGGGGGATCTGACGCTGATCGGCAACTGCGGGGCGTCGGTGAGGAACATCGAGGATGGAAACACAAATCGTCAGGTGGCCGCGCTTGCTGCCCATCGCGGCCACCACAACCCAACCGACAACGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence
MHLTTTSSNSTASNANNNNNNNNNNTTNTNNNNNSSSSNNNNNNTSNTNGTNNNNNNSSSNSNNNSTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASGGSGATAGSASGAGSGAVANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGATNGGAANGGAGSAAGAGSGASAGASAGAGNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGVGSGHGSGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY