Basic Information

Insect: Drosophila aldrichi
Gene Symbol: Runx1
Assembly: GCA_035045965.1
Location: JAWNOM010000125.1:1426312-1448501[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7 1.9e+04 -13.9 11.0 59 75 25 42 18 48 0.50

2 3 4.2e-73 1.1e-69 232.0 0.0 3 129 99 225 97 225 0.98

3 3 3.4 9.2e+03 -3.8 0.0 68 91 599 623 594 626 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7	1.9e+04	-13.9	11.0	59	75	25	42	18	48	0.50
2	3	4.2e-73	1.1e-69	232.0	0.0	3	129	99	225	97	225	0.98
3	3	3.4	9.2e+03	-3.8	0.0	68	91	599	623	594	626	0.74

Sequence Information

Coding Sequence: atgcatttgacaACGACGAGCAGTAATTCGACGGCATCCAATGCCAAttccaataacaacaacaccaacaacaataacaacaacaacacagccaacaacaacaacaataacacagcgagcagcaacaacaacaacaacagcaacacaaatggcaccaacaacaacaacaacagctcaagcagcaacaacaacagcaacaacacagaACAAAACACACCGCCCACACCCGCCCAGCTGCTGAACGAGGCCTACACAAAAATGACCTCGGACATCTTGGCTGAACGCACCCTGGGCGACTTCCTCACCGAGCATCCCGGCGAGCTAATACGAACCAGCAGTCCGCTCTTTGTCTGCACCGTCCTGCCGCCGCACTGGCGCTCCAACAAGACACTGCCGGTGGCCTTCAAGGTGGTCTCCCTGGGCGACATCATGGACGGCACCATGGTGACGGTGCGCGCCGGCAACGACGAGAACTACTGCGCCGAGCTGCGCAACTGTACCGCCGTCATGAAGAACCAGGTGGCCAAGTTCAATGATCTGCGCTTCGTGGGACGCAGCGGTCGAGGCAAGAGCTTCACACTAACCATCACCGTGTCAACGAATCCACCCCACATAGCCACCTACAACAAGGCGATCAAAGTGACTGTCGATGGGCCACGCGAGCCGCGCTCCAAAACCATGTTATCCCTTttagggcaacaacaacaattccacTTTGCATTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCACTCTCCGGCTTCCGCATGCCACCCATTGGCAACTGTCAGAGTGCCAGCAATACGCATTGGGGCTATGGATCGGCGGCGTCTGCCTACTCGCCGTACTTGGCCAGCAGTGGACTCTCCTCCTGCACCACGCCCACATCAGCACAGTTCAACAATCCGGCACTGGGCTTCACCTGCTCGTCCAACGATCAGACCAACAACCAGGACTTTAGTGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCCGACTCGACGGCCAGTGATCTGGACCAGCATCTCAGCAGCCTGGTCGGCTCGAGCAGCGGCCAGATGTCGCACCACAGCCTGCTGGGCGCCAGCGGACAGACGTCCATCACATCGACGGTGAACGGGGCGAGCGCCGGCAGCGGCGCCACCGCTGGCAGCGCAACGGGcgccggcggcggcggcggcggcggtggggCCAATTCGATTCTGGTGCCGCGATACCACACCAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAGAATGGGCCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGATTTGCTGTCCACCAATACGCCGAACCTGGGCAGCGGCACTGGCGCCGGGGCGAGCAACGGAGGAGCTGCCAACGGTGCGGCGAGTGCAGCTGGCGCTGGCAGCGGCGGAGCGGCCGGAGCATCAGCCGGCGCCGTCAATCCCGCCATGCTGGGCGCCAACCAGAACTTTCCGGGCATTGTGAACCAGGCCCAGCATGCCTCCGCCTCGGCCTATGGCGGCGGCGTCGGcgttggcgtcggcgtcggtgTGGGCGGCGGGCATGGCAGCGGCGCTGGAGCCACGGCCGCCGGCTGCAACGGCTCGCTGTATCCGGTGCTGCCGGCCAGCCTGCTCTACTCGCAGCTGTACACTGCCGCCAATCAGTCGGCGCACGGCTTCCACTCGCACACGCTGCCGGCGCACGCGTCGCCCAACTCGTCCGTGCACGGCGAGCTGCAGAGCGTCATGGATCACATCAGTAACGTGGGCGTACGGCAGCAGCACAACATCATGGCCGGCGGGGGCGTGGCGCACCCGGGCGACCTCACGCTGATCGGCAACTGCGGCGCCTCGGTGCGCAACATCGAGGACGGGAACACCAATCGGCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACTGACAACGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence: MHLTTTSSNSTASNANSNNNNTNNNNNNNTANNNNNNTASSNNNNNSNTNGTNNNNNSSSSNNNSNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQTNNQDFSGATNRDCVPMLPDSTASDLDQHLSSLVGSSSGQMSHHSLLGASGQTSITSTVNGASAGSGATAGSATGAGGGGGGGGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGTGAGASNGGAANGAASAAGAGSGGAAGASAGAVNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGVGVGGGHGSGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00568029;
90% Identity: iTF_00804957;
80% Identity: -