Zbog003486.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Zaprionus bogoriensis
Gene Symbol
Runx1
Assembly
GCA_035046045.1
Location
JAWNOI010000038.1:5795775-5811019[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 5 1.6e+04 -11.8 10.5 57 79 21 43 12 61 0.65
2 3 3e-73 9.3e-70 232.0 0.0 3 129 92 218 90 218 0.98
3 3 2.9 9.2e+03 -4.0 0.0 69 91 599 622 595 625 0.73

Sequence Information

Coding Sequence
atgCATTTGACAACCACGAGCAGCAATTCGGCGGCTgcaaatgccaacaacaacaacaacgcagcgaacaacaacaacaactcgagcagcagcaacaacaacaacacaagcaacaCAAATGGcaccgccaacaacaacaacaacaacaactcgagcagcaacagcaacaacaacaacagcaccgaACAGAACACACCGCCCACACCCGCGCAGCTGCTCAACGAGGCATACACCAAGATGACCTCCGACATTCTGGCCGAGCGCACCTTGGGCGACTTCCTCACCGAGCATCCCGGCGAGCTAATCCGCACCAGCAGCCCCCTGTTCGTCTGCACCGTCCTGCCGCCGCACTGGCGCTCCAACAAGACGCTGCCCGTCGCCTTCAAGGTCGTCTCGCTGGGCGACATCATGGACGGCACCATGGTGACGGTGCGGGCGGGCAACGACGAGAACTACTGCGCCGAGCTGCGCAACTGTACCGCCGTCATGAAGAATCAAGTGGCCAAGTTCAACGATCTGCGGTTCGTGGGGCGCAGCGGAAGAGGGAAGAGCTTCACGTTAACCATCACCGTGTCGACGAATCCCCCACACATCGCCACCTACAACAAGGCGATCAAAGTCACCGTCGATGGGCCGCGCGAGCCACGCTCCAAGACAATGCTATCCCTTttagggcaacaacaacaatttcactTCGCCTTCGGCCAGCGACCCTTCCACTTCTCGACGGATCCGCTCTCGGGCTTCCGCATGCCGCCCATCGGCAACTGTCAGAGTGCCAGCAACACGCACTGGGGCTACGGATCGGCAGCGTCGGCCTATTCACCGTACTTGGCCAGCAGTGGACTCTCTTCGTGCACCACGCCCACATCGGCGCAGTTTAACAATCCGGCGCTGGGATTCACCTGCTCGTCCAACGATCAGACCAACAATCAGGATTTTGGCGGCGCTACCAATCGCGACTGTGTGCCAATGCTACCCGATTCGACGGCCAGCGACCTGGACCAGCACCTGAGCAGCCTGGTCGGCTCGACTAGCGGCCAGATGTCGCACCATAGCCTGCTTGGCGCCAGCGGCCAGACATCGATTACGTCGACGGTGAATGGTGccagtggcggcagcggcgcaacCGCCGGCAGTGCAGcgggcgctggcagcggcgctGGGGCCAACTCGATTCTAGTGCCGCGCTACCACACGAACGCGAGCAACGAGTACAACGTGCACTCCAGCCAGAACGGACCGCGCAGCCTCAGCGACAGCTCGCAGGCGGAGTCGCCGGTGCAGGAGGATCTGCTGTCGACGAACACACCGAAtctgggcagcggcagcggcggtggtggcggtggcggcggtggtggtggcggcggtgcGACCAACGGTGGCGCTGCAAACGGTggtgctggcagcgctgctggcgctggcagcggcggcggcacagcTGGCTCCTCGTCCACCAATCCCGCCATGCTGGGCGCCAATCAAAATTTTCCGGGCATCGTCAATCAGGCTCAGCATGCCTCCGCCTCGGCCTAtggcgttggcggcggcgtcggcgtggGCGTTGGCGTGGGCGGTCATGGCAGCAGCGCCGGTGCCAGCGCCGCCGGCTGCAACGGATCGCTGTATCCGGTGCTGCCCGCGAGCCTGCTCTACTCGCAGCTGTACACGGCGGCCAATCAGTCGGCTCACGGCTTCCACTCGCACACGCTGCCGGCGCACGCATCGCCCAACTCGTCGGTGCACGGCGAGCTGCAGAGCGTCATGGATCACATCAGCAATGTGGgcgtgcggcagcagcacaacatcATGACCGGCGGTGGGGTGGCGCATCCCGGCGACCTCACGCTCATCGGGAACTGTGGGGCGTCGGTGCGTAACATCGAGGATGGGAACACCAATCGGCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACCGACAACGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence
MHLTTTSSNSAAANANNNNNAANNNNNSSSSNNNNTSNTNGTANNNNNNNSSSNSNNNNSTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQTNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASGGSGATAGSAAGAGSGAGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGGGGGGGGGGGATNGGAANGGAGSAAGAGSGGGTAGSSSTNPAMLGANQNFPGIVNQAQHASASAYGVGGGVGVGVGVGGHGSSAGASAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00518932;
90% Identity
iTF_00804957;
80% Identity
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