Basic Information

Insect: Drosophila macrospina
Gene Symbol: Runx1
Assembly: GCA_035042075.1
Location: JAWNLW010000500.1:707833-724722[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6 1.7e+04 -13.8 11.3 59 68 34 43 17 75 0.62

2 3 3.6e-73 1e-69 232.0 0.0 3 129 105 231 103 231 0.98

3 3 3.3 9.3e+03 -3.9 0.0 68 91 599 623 595 626 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6	1.7e+04	-13.8	11.3	59	68	34	43	17	75	0.62
2	3	3.6e-73	1e-69	232.0	0.0	3	129	105	231	103	231	0.98
3	3	3.3	9.3e+03	-3.9	0.0	68	91	599	623	595	626	0.74

Sequence Information

Coding Sequence: atgcatttgacaaccaccagcagcaactcGACGGCATCTAatgccaataacaacaacaacaacaacaataacaataataacaacaacaacacagcgaacaacaacaacaactcgagcagcaacagcaacaacaataacaacaacaacaacaacacaaccaaCACAAAtggcacaaacaacaacaacaactcaagcagcaacagcaacaacaacaacagcaccgaACAAAACACACCACCCACACCTGCCCAGCTGCTAAATGAGGCCTACACGAAGATGACCTCTGACATACTGGCCGAGCGAACACTGGGCGACTTCCTCACCGAGCATCCTGGCGAGCTCATCAGGACTAGCAGCCCCCTCTTTGTGTGCACCGTCCTGCCGCCGCATTGGCGCTCCAACAAGACGCTGCCGGTGGCCTTCAAGGTCGTCTCACTGGGCGACATCATGGATGGCACCATGGTCACCGTGCGGGCCGGCAACGATGAGAACTATTGTGCCGAGCTGCGCAACTGCACCGCCGTCATGAAGAACCAGGTGGCCAAGTTCAATGATCTGCGATTTGTGGGACGCAGCGGCAGAGGGAAGAGCTTCACATTAACCATCACCGTGTCAACGAATCCACCACACATAGCCACCTACAACAAGGCGATCAAAGTGACTGTCGATGGGCCACGCGAACCACGCTCCAAGACCATGTTATCCCTTttagggcaacaacaacaattccacTTCGCCTTCGGCCAGCGACCGTTCCACTTCTCCACGGATCCATTGTCCGGCTTCCGCATGCCACCGATTGGCAACTGTCAGAGTGCCAGCAACACGCATTGGGGCTACGGATCGGCGGCCTCGGCCTACTCACCGTACTTGGCCAGCAGCGGACTATCGTCCTGCACCACGCCCACATCGGCACAGTTCAACAATCCCGCGTTGGGCTTCACCTGCTCCTCCAACGATCAGAGCAACAATCAGGACTTCGGTGGCGCCACAAATCGCGACTGTGTGCCAATGCTGCCTGATTCAACGGCCAGCGATCTGGACCAGCATCTGAGCAGTCTGGTGGGCTCGACCAGTGGCCAGATGTCGCATCATAGTTTGTTGGGCGCCAGTGGCCAGACGTCGATCACCTCGACGGTGAATGGAGCGAGCACCGGGAGTGGGGCAACAGCTGGGAGTGCAGCGGGTGCTGGCAGCGGTGCTGGAGCCAACTCCATCCTCGTGCCACGTTATCATACCAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAGAATGGGCCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGATCTGCTGTCCACCAACACACCAAATctgggcagcggcagcggcggtggTGCCACAAATGGTGGGGCTGCAAATGGTGGACCTGGCAGTGCAGCTGGTGCTGGCAGCGGTGGGGCGGCGGGTGCATCGGCTGGAGCTGGTAATCCCGCCATGTTGGGCGCCAATCAAAACTTTCCGGGCATCGTCAACCAGGCACAACACGCCTCCGCCTCGGCCTACGGCGGCGGCGTcggcgttggcgtcggcgGTGGCCATGGCGGCGGCGCAGGCGCCACAGCCGCCGGCTGCAATGGCTCGCTGTATCCGGTGCTGCCCGCCAGTCTGCTCTACTCGCAGCTGTATACCGCTGCCAATCAGTCGGCGCACGGCTTCCACTCGCACACGCTGCCGTCGCACGCCTCGCCCAACTCCTCGGTGCATGGGGAGCTGCAGAGCGTGATGGATCACATTAGCAATGTGGGGGTGCGGCAGCAGCACAATATCATGACGGGCGGTGGGGTGGCGCATCCGGGTGATCTGACGCTGATTGGCAACTGTGGGGCGTCGGTGAGGAACATCGAGGATGGGAACACAAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACTGACAACGGGGGCAGCGTGTGGAGGCCATATTGA
Protein Sequence: MHLTTTSSNSTASNANNNNNNNNNNNNNNNTANNNNNSSSNSNNNNNNNNNTTNTNGTNNNNNSSSNSNNNNSTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASTGSGATAGSAAGAGSGAGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGATNGGAANGGPGSAAGAGSGGAAGASAGAGNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPSHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00518932;
90% Identity: iTF_00804957;
80% Identity: -