Dvii005076.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila virilis
Gene Symbol
Runx1
Assembly
GCA_007989325.2
Location
CM017604.2:25680042-25717070[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 4 1.4e+04 -10.9 8.4 59 77 18 36 8 45 0.64
2 3 2.3e-73 8.3e-70 232.0 0.0 3 129 93 219 91 219 0.98
3 3 2.2 7.6e+03 -3.9 0.0 68 91 593 617 589 620 0.74

Sequence Information

Coding Sequence
atgcatttgacaACCACGAGCGGCAATTCGACGGCATCGAATgccaatagcaacaacaacaacaacagcaacaacaataacaacaacacagctaacaacaataactccagcagcagcaacaacaacaacacaagcaACACAAATggctccaacaacaacaacagctcaagcagcaacaacaataccgAACAGAATACGCCCCCAACACCCGCCCAGCTACTAAATGAGGCATACACCAAAATGACCTCGGACATATTGGCTGAACGCACCTTGGGCGATTTCCTCACCGAGCATCCCGGCGAGCTAATAAGAACAAGCAGCCCGCTTTTTGTCTGCACCGTCCTGCCACCGCACTGGCGCTCTAATAAGACGCTGCCGGTGGCCTTCAAGGTCGTCTCTCTGGGCGACATCATGGACGGTACCATGGTCACGGTTCGCGCTGGCAACGATGAGAACTACTGCGCCGAGCTGCGCAACTGCACAGCCGTCATGAAAAACCAGGTGGCCAAGTTCAACGATCTGCGATTTGTCGGACGCAGTGGCAGGGGAAAGAGCTTCACATTAACCATCACAGTGTCAACGAATCCACCACATATAGCAACATATAACAAGGCGATCAAAGTAACCGTCGATGGGCCACGCGAGCCGCGCTCCAAAACCATGTTATCCCTTttagggcaacaacaacaatttcactTCGCATTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCCCTATCCGGCTTCCGGATGCCGCCAATTGGCAACTGTCAGAATATGTCCCAATTTGGTTTAGGTGCCAGCAACACGCATTGGGGCTACGGATCAGCGGCATCTGCATACTCGCCGTACTTAGCTAGCAGCGGACTATCCTCCTGCACTACGCCCACCTCAGCGCAGTTTAACAATCCAGCATTGGGCTTCACCTGTTCCTCCAATGACCAAAGCAACAATCAGGACTTTGGGGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCAGATTCAACAGCCAGCGATTTGGATCAGCATCTCAGCAGTCTAGTCGGATCCTCCAGTGGGCAGATGTCACATCATAGCTTGTTGGGCGCCAGTGGACAGACATCTATTACATCGACGGTGAATGGGGCAGGCGCCGGCAGCGGGGCAACCGCAGGAAGTGCAACAGGCgctggcggcggtggtggtgccAACTCGATTCTGGTGCCACGATATCATACCAACGCTAGCAATGAGTACAACGTGCATTCCAGCCAGAACGGACCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAATCGCCGGTGCAGGAGGATCTGCTGTCCACCAACACACCCAACCtgggcagcggcagtggcGCCGGTGCCAGCAATGGCGGTGCCGCCAACGGTGCTGCTagtgctgctggcgctggcagCGGCGCCTCAGCGGGTGCATCGGCTGGCGCTGGTAATCCCGCCATGCTGGGTGCCAATCAAAACTTTCCGGGCATTGTTAACCAGGCACAGcatgcctctgcctctgcgtATGGGGGCGGCGTAGGTGTTGGCGTGGGCGGCGGGCATGGCGGCGGTGCTGGGGCCACGGCCGCCGGCTGCAATGGATCGCTTTACCCGGTGCTCCCAGCCAGCCTGCTGTACTCGCAGCTATATACCGCCGCCAATCAGTCGGCGCACGGCTTTCATTCGCACACGCTGCCGGCGCATGCGTCGCCCAACTCCTCCGTGCATGGGGAGCTGCAGAGCGTAATGGATCACATCAGCAATGTCGGCGTACGGCAACAGCATAACATTATGACCGGCGGGGGCGTGGCGCATCCAGGCGATCTGACACTGATTGGCAACTGCGGCGCGTCGGTGAGGAACATCGAGGATGGGAACACAAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCAGCCACCACAACCCAACTGATAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence
MHLTTTSGNSTASNANSNNNNNSNNNNNNTANNNNSSSSNNNNTSNTNGSNNNNSSSSNNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQNMSQFGLGASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSSSGQMSHHSLLGASGQTSITSTVNGAGAGSGATAGSATGAGGGGGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGAGASNGGAANGAASAAGAGSGASAGASAGAGNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRSHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00568029;
90% Identity
iTF_00804957;
80% Identity
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