Dnov001067.1
Basic Information
- Insect
- Drosophila novamexicana
- Gene Symbol
- Runx1
- Assembly
- GCA_003285875.3
- Location
- NW:1334404-1350462[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 4 1.3e+04 -11.5 9.5 57 77 17 37 9 46 0.66 2 3 2.3e-73 7.4e-70 232.0 0.0 3 129 96 222 94 222 0.98 3 3 2.2 6.9e+03 -3.9 0.0 68 91 589 613 585 616 0.74
Sequence Information
- Coding Sequence
- atgcatttgacaACCACGAGCAGCAACTCGACGGCATCGAATgccaatagcaacaacaacaacaataacagcaacaacaataataacaacacagctaacaacaacaactccagcagcagcaacaacaacaacacaagcaACACGAATggctccaacaacaacaacaacaacagctcaagcagcaacaacaacaccgaACAGAACACGCCCCCAACACCCGCCCAGCTACTAAATGAGGCATACACCAAAATGACCTCGGACATATTGGCTGAACGCACCTTGGGCGATTTCCTCACCGAGCATCCCGGCGAGCTAATAAGAACAAGCAGCCCGCTCTTCGTCTGCACCGTCCTGCCACCGCACTGGCGCTCCAATAAGACACTGCCGGTGGCCTTCAAGGTCGTCTCCTTGGGCGACATCATGGACGGCACCATGGTCACGGTTCGCGCTGGCAACGATGAGAACTACTGCGCCGAGCTGCGCAATTGCACAGCCGTCATGAAGAACCAGGTGGCCAAGTTCAACGATCTGCGATTTGTCGGACGCAGCGGCAGGGGAAAGAGCTTCACATTAACCATCACAGTGTCAACGAATCCACCACATATAGCCACATATAACAAGGCGATCAAAGTAACCGTCGATGGGCCACGCGAGCCGCGCTCCAAAACCATGTTATCCCTTttagggcaacaacaacaatttcactTCGCATTTGGCCAGCGACCGTTCCACTTCTCGACGGATCCCCTATCCGGCTTCCGGATGCCGCCAATTGGCAACTGTCAGAGTGCCAGCAACACGCATTGGGGCTACGGTTCAGCGGCATCTGCATACTCGCCGTACTTAGCTAGCAGCGGACTATCCTCCTGCACTACGCCCACCTCAGCGCAGTTTAACAATCCAGCGTTGGGCTTCACCTGTTCCTCCAATGACCAAAGCAACAATCAGGACTTTGGGGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCAGACTCGACAGCCAGCGATTTGGATCAGCATCTGAGCAGTCTGGTCGGATCCTCCAGTGGCCAGATGTCGCATCATAGCTTGTTGGGCGCCAGTGGACAGACATCTATTACATCGACAGTGAATGGGGCGGGCGCCGGCAGCGGGGCAACCGCAGGAAGTGCCACGggcgctggcggcggcggtggtgccAACTCGATTCTGGTGCCACGATATCATACCAACGCCAGCAATGAGTATAACGTGCATTCCAGCCAGAACGGACCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAATCGCCGGTGCAGGAGGATCTGCTGTCCACCAACACACCCAACttgggcagcggcagcggcgccggTGCGAGCAATGGCGGCGCCGCCAACGGTGCTGCTAGTGCTGCAGGCGGTGGCAGCGGCGCCTCAGCGGGTGCTTCGGCTGGCGCTGGTAATCCCGCCATGCTGGGCGCCAATCAAAACTTTCCGGGCATTGTTAACCAGGCACAGCATGCCTCTGCCTCGGCGTATGGCGGCGGCGTAGGTGTTGGCGTGGGCGGAGGGCATGGCGGCGGTGCTGGGGCCACAGCCGCCGGCTGCAATGGATCGCTCTACCCGGTGCTCCCAGCCAGCCTGCTCTACTCGCAGCTATATACTGCCGCCAATCAGTCGGCTCACGGCTTTCATTCGCACACGCTGCCGGCGCATGCGTCGCCCAACTCCTCCGTGCATGGGGAGCTGCAGAGCGTAATGGATCACATCAGCAATGTCGGCGTACGGCAGCAGCATAACATTATGACCGGCGGGGGCGTGGCGCATCCAGGCGATCTGACACTGATTGGCAACTGCGGCGCGTCGGTGAGAAACATCGAGGACGGGAACACAAATCGTCAGGTGGCCGCGCTTGCTGCCCATCGCGGCCACCACAACCCAACTGACAACGGGGGCAGCGTCTGGAGGCCATATTGA
- Protein Sequence
- MHLTTTSSNSTASNANSNNNNNNSNNNNNNTANNNNSSSSNNNNTSNTNGSNNNNNNSSSSNNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSSSGQMSHHSLLGASGQTSITSTVNGAGAGSGATAGSATGAGGGGGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGAGASNGGAANGAASAAGGGSGASAGASAGAGNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01553740;
- 90% Identity
- iTF_00804957;
- 80% Identity
- iTF_00474991;