Basic Information

Insect: Euclidia mi
Gene Symbol: run
Assembly: GCA_944738845.2
Location: CALYKX020000132.1:4012407-4021862[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.3e-71 2.3e-67 226.7 0.0 2 129 21 148 20 148 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.3e-71	2.3e-67	226.7	0.0	2	129	21	148	20	148	0.98

Sequence Information

Coding Sequence: ATGCACCTCCCGCACGCAAGCCCTCCGGCCCCCAGCATGGCGGACGTCTACTCGCACATCCACGAGTACTACCGGCAGAGTCACGGCGAGCTGGTGCAGACCGGCTCCCCGGCGGTGCTGTGCTCTGCGCTGCCTGGACACTGGCGCTCCAACAAGTCGCTGCCGGTCGCCTTCAAGGTGGTCGCGCTGGACGACGTGCAGGACGGCACCCTGGTCACCATCAAGGCTGGCAATGACGAGAACGCGATGGCGGAACTGAGGAATTGTACCGCCGTCATGAAGAACCAAGTCGCAAAGTTCAATGATTTGAGATTCGTGGGTCGCAGTGGCCGCGGAAAGTCATTCTCGCTGACTATCACCATCAGCACATTCCCGAGCCAAGTGGCCACCTATACCAAAGCTATCAAAGTCACAGTCGACGGCCCAAGGGAACCTAGAACTAAGCAAAATTATGGATACGGACACCCGGGTGCGTTCAGTCCATTCCTATTGAACCCCGGTTGGCTGGATGCGGCGTACCTCAACTACGCCTGGGCCGACTATTTCAGACCGCCACAAATGCGTGATACAACGGCTGCACTTGTTAAAGGTGGCGCAGGACCTATCACAACTCCTCCCGTAACGTTACCGGGAGCAGATCTGTTCCCGTTCCCGCCAGCGATCTCAAACCTCCCGCCGGGTGGACTCATCCCTCCTCCCGGCGCTTTCTTACCACCAAACGGACTTCTACCATTCCCACCACATCCAGCAGACCTGGCACTAAAGACGCTACCACCAGAACTATCACTCAAAAACGGCGTCAACCCTTACGATGCTCTGAGGCAGTTGCAAAGCAATATGTCCATCGACACCTCAAGTGCTCGACTGTCGCCTACGAGCAGCAGACAAAGTGGTAGCCCAAGAAGCATGACAAACGCAAGCCCTGACAGATCGAAAGCTGATTCGAAATCCGAAGTTAACTCGATGCATGACGCAACGATCTCGGACGAATCTGATGAAGAACCCATTGAAGTAGTAAAATCCGCGTTCCACCCGACGCGGCCGGCGAACGTCGAGCTACAAGAAATGAAGAGGGTCCAAGCTGCGGACTCCACGGTCGCAGACAGGCCGAGGGTCCGAAACGAACTGAAGGCGCCTTCTCAACGCACCACCAGAGTGCTCTCATCTAGTCCAACTTCAACCAAAATCTCAAATAGCGCGATAGCGACGCACAAATCAGTGTGGCGGCCATATTGA
Protein Sequence: MHLPHASPPAPSMADVYSHIHEYYRQSHGELVQTGSPAVLCSALPGHWRSNKSLPVAFKVVALDDVQDGTLVTIKAGNDENAMAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTITISTFPSQVATYTKAIKVTVDGPREPRTKQNYGYGHPGAFSPFLLNPGWLDAAYLNYAWADYFRPPQMRDTTAALVKGGAGPITTPPVTLPGADLFPFPPAISNLPPGGLIPPPGAFLPPNGLLPFPPHPADLALKTLPPELSLKNGVNPYDALRQLQSNMSIDTSSARLSPTSSRQSGSPRSMTNASPDRSKADSKSEVNSMHDATISDESDEEPIEVVKSAFHPTRPANVELQEMKRVQAADSTVADRPRVRNELKAPSQRTTRVLSSSPTSTKISNSAIATHKSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00280905; iTF_00072046; iTF_00171530; iTF_01564332; iTF_00821551; iTF_01332319; iTF_00431905; iTF_01147202; iTF_01115490; iTF_00957733; iTF_01495558; iTF_01154793; iTF_01494091; iTF_01337549; iTF_01175983; iTF_00249489; iTF_01402518; iTF_01494839; iTF_01156057; iTF_01158491; iTF_01153630; iTF_01487490; iTF_00326859; iTF_01259854; iTF_00951567; iTF_01221268; iTF_00017116; iTF_01377244; iTF_00000093; iTF_00374942; iTF_00017952; iTF_00383392; iTF_00235650; iTF_00236423; iTF_01489915; iTF_00621796; iTF_00185912; iTF_00185083; iTF_00149151; iTF_00148260; iTF_01463032; iTF_01547298; iTF_00207620; iTF_00208596; iTF_00649796; iTF_00038465; iTF_00467969; iTF_00723745; iTF_00785793; iTF_01028033; iTF_00147074; iTF_00711586; iTF_01063522; iTF_01416546; iTF_00907651; iTF_01083075; iTF_00826596; iTF_00851492; iTF_01534564; iTF_00042405; iTF_00467237; iTF_01029925; iTF_01092837; iTF_00674086; iTF_00913382; iTF_01285318; iTF_01526790; iTF_00120263; iTF_01246599; iTF_01251527; iTF_01525703; iTF_00124008; iTF_01361352; iTF_00446889; iTF_00449897; iTF_00666281; iTF_01192393; iTF_01341993; iTF_00006858; iTF_00049674; iTF_00784170; iTF_00825355; iTF_00036396; iTF_00924364; iTF_01119052; iTF_01230284; iTF_01264172; iTF_01415596; iTF_00039565; iTF_00044237; iTF_00323245; iTF_00784973; iTF_00895693; iTF_01084909; iTF_00037550; iTF_00111374; iTF_00300942; iTF_01094670; iTF_01116942; iTF_00122127; iTF_00373679; iTF_00928431; iTF_01207887; iTF_01533711; iTF_00301872; iTF_00906832; iTF_01118032; iTF_00041553; iTF_00121169; iTF_00176881; iTF_00444881; iTF_01025745; iTF_01084017; iTF_00071186; iTF_00299923; iTF_01093811; iTF_01339731; iTF_01439667; iTF_00123124; iTF_00648884; iTF_00685204; iTF_01338260; iTF_00040565; iTF_00043253; iTF_00172501; iTF_00887989; iTF_01208981; iTF_01362869; iTF_01424821; iTF_00142870; iTF_00745398; iTF_00973494; iTF_01064406; iTF_00425143; iTF_00448791; iTF_00622583; iTF_00757911; iTF_01061655; iTF_00237240; iTF_00363801; iTF_00667130; iTF_00830938; iTF_01030906; iTF_01440762; iTF_01531738; iTF_00033595; iTF_00445883; iTF_00250237; iTF_00905885; iTF_01028989; iTF_00850366; iTF_00783199; iTF_00952479; iTF_00771648; iTF_00935456; iTF_00994144; iTF_01027072; iTF_01062528; iTF_01076160; iTF_01532800; iTF_00737249; iTF_00686116; iTF_01182443; iTF_00361388; iTF_01528973; iTF_00266959; iTF_01335703; iTF_01528055; iTF_00119384; iTF_00632536; iTF_00662008; iTF_00661053; iTF_01161089; iTF_00699874; iTF_01316098; iTF_00113910; iTF_01317053; iTF_00186911; iTF_01362275; iTF_00701734; iTF_01073382; iTF_00055175; iTF_00809831; iTF_00273386; iTF_00274220; iTF_00808877; iTF_01171239; iTF_01170344; iTF_01172104; iTF_00700777; iTF_00318666; iTF_00698954; iTF_00702666; iTF_01099658; iTF_01500874; iTF_01336595; iTF_00844092; iTF_00275019; iTF_00276043; iTF_00697099; iTF_00726059; iTF_00376877; iTF_01509357; iTF_00696279; iTF_00698046; iTF_00077262; iTF_00354862; iTF_00662862; iTF_01179279; iTF_01180102; iTF_00827760; iTF_01538514; iTF_00150259; iTF_00810771; iTF_00967827; iTF_01403219; iTF_00406484; iTF_00407342; iTF_00704725; iTF_00390136; iTF_00856376; iTF_00909528; iTF_01443608; iTF_00026617; iTF_00027533; iTF_00761401; iTF_01436790; iTF_00818137; iTF_01428826; iTF_01219559; iTF_00177851; iTF_00703709; iTF_00790973; iTF_00790018; iTF_01010142; iTF_00063354; iTF_00705760; iTF_01401056; iTF_00382343; iTF_00284298; iTF_00035414; iTF_00075233; iTF_00076226; iTF_00074251; iTF_00960707; iTF_00364687; iTF_01281994; iTF_00408173; iTF_01071408; iTF_01279039; iTF_01281078; iTF_01279960; iTF_00837241; iTF_01124378; iTF_01125219; iTF_00834399; iTF_00970183; iTF_00795471; iTF_00673266; iTF_00971005; iTF_00887198; iTF_01082208; iTF_00787395; iTF_00801577; iTF_01091465; iTF_01438666; iTF_00352812; iTF_01437741; iTF_01245710; iTF_01152815; iTF_00009776; iTF_00008674; iTF_00353851; iTF_00025052; iTF_01020959; iTF_00204904; iTF_00197897; iTF_00822659; iTF_00278886; iTF_00888966; iTF_01149351; iTF_01140008; iTF_00194954; iTF_01560907; iTF_00156972; iTF_00874224; iTF_00875075; iTF_00875924; iTF_01302064; iTF_01367472; iTF_00651505; iTF_00922675; iTF_00869397; iTF_00161334; iTF_00162279; iTF_00640056; iTF_00012707; iTF_00923384; iTF_00000957; iTF_00736393; iTF_00007782; iTF_00634090; iTF_00287833; iTF_00635176; iTF_00636045; iTF_00908585; iTF_00404467; iTF_00637240; iTF_01166363; iTF_00794093; iTF_01173047; iTF_01220429; iTF_01144334; iTF_00072495; iTF_01081359; iTF_01503624; iTF_01502737; iTF_00114705; iTF_00345587; iTF_00953297; iTF_00954180; iTF_00006066; iTF_00022578; iTF_00772650; iTF_01463937; iTF_00462146; iTF_00341989; iTF_00680294; iTF_01135528; iTF_00155086; iTF_00325143; iTF_00156025; iTF_00021114; iTF_01134556; iTF_00206770; iTF_00205834; iTF_00317888; iTF_00695251; iTF_01222259; iTF_00204148; iTF_00840101; iTF_00878645; iTF_01206305; iTF_01204643; iTF_01205477; iTF_01202247; iTF_01203817; iTF_01203021; iTF_00947669; iTF_00708950; iTF_00930996; iTF_00932190; iTF_00710806; iTF_00709957; iTF_01561794; iTF_00357189; iTF_01193388; iTF_00358295; iTF_00823702; iTF_00751799; iTF_00942583; iTF_00858317; iTF_00428773; iTF_01358661; iTF_00290440; iTF_00818920; iTF_01429708; iTF_00341109; iTF_00427866; iTF_00819835; iTF_00859232; iTF_01197495; iTF_01501860; iTF_01151834; iTF_00706716; iTF_01151000; iTF_00835322; iTF_00836290; iTF_00806464; iTF_00321372; iTF_00638427; iTF_00770876; iTF_01019997; iTF_01090461; iTF_00146174; iTF_00277150; iTF_00441246; iTF_01360380; iTF_00647774; iTF_01333502; iTF_01386495; iTF_01385486; iTF_01388242; iTF_00682144; iTF_00681441; iTF_00683098; iTF_01491648; iTF_00715584; iTF_01331200;
90% Identity: iTF_00280905;
80% Identity: -