Basic Information

Insect: Alsophila aescularia
Gene Symbol: run
Assembly: GCA_946251895.1
Location: CAMIUG010001093.1:482866-493305[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.4e-71 4.4e-67 224.5 0.0 2 129 19 146 18 146 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.4e-71	4.4e-67	224.5	0.0	2	129	19	146	18	146	0.98

Sequence Information

Coding Sequence: ATGCACCTCCCGCACGCGAGTCCCCCGGCGATGGCTGACGTGTACTCCCACATCCACGACTACTACCGGCAGAGTCACGGCGAGTTGGTGCCGACTGGCTCCCCAGCCGTGCTCTGCTCGGCACTGCCGGGCCACTGGCGCTCCAACAAGTCTCTCCCGGTGGCTTTCAAAGTGGTGGCGCTGGACGACGTGCAGGATGGCACTCTTGTCACGATCAAGGCTGGGAACGACGAAAACGTGATGGCGGAGTTGAGGAACTGCACGGCGGTGATGAAGAACCAGGTGGCGAAGTTCAACGACCTTCGCTTTGTGGGGCGCAGTGGGCGCGGGAAGTCCTTCTCGCTCACCATTACCATCAGCTCGTATCCCAGCCAAGTCGCCACCTACATCAAGGCTATTAAAGTCACAGTGGACGGACCAAGAGAACCTAGGACTAAGCAAAATTACGGCTACGGCGTCCCCGGAGCGTTTAGCCCGTTCCTCCTGAACCCAGGGTGGTTAGACGCTGCCTATCTCAACTACGCGTGGGCGGACTACTTCAGGCCACCAACCATGAGGGACCCAGCTGCTGCTCTTGTCAAAGGTAGCCCAGCACCTTTAGCGACGCAACCGGTAGGAGTTGATCTATTTCCGTTTCCGCCAGCAATGACGAATCTTCCATCGAGTGGTATGCTTCCACCGCCGGGAGTGTTTCTACCTCCAAATGGACTTTTACCATTCCCAACCCATCCTGCCGATCTCGCGCTAAAATCATTACCACCGGAGCTCTCACTAAAGAATGGGATGAGCCCTTACGACGCATTGAGACATTTACAAAATAATGTATCGCCAATGGATACGTCGAGCGCTCGTCTGTCTCCGACGAGCAGTAGACAGAGTGGCAGTCCGCGTAGCATGGCCAACGCCAGTCCAGACAGATCGAAAGCAGACTCCAAATCAGAAGTGAACTCGATGCACGATGCGACAATTACTGACGAGTCGGACGAAGAGCCCATTGAAGTGGTGAAGTCCGCGTTCCATCCGACGCGACCTGCGAATGTGGAATTGCAGGAGATGAAGCGTGTTCAAGCGGCCGACTCCACGGTGGCGGATCGGCCTCGAGTCCGCAGCGAACTGAAAGCTCACTCGCAACGAACGAGGGTTCTTTCCACAAGTCCGACTTCCACCAAACTCACAAACGGGACTTTGTCAACGCACAAATCCGTTTGGCGACCATATTGA
Protein Sequence: MHLPHASPPAMADVYSHIHDYYRQSHGELVPTGSPAVLCSALPGHWRSNKSLPVAFKVVALDDVQDGTLVTIKAGNDENVMAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTITISSYPSQVATYIKAIKVTVDGPREPRTKQNYGYGVPGAFSPFLLNPGWLDAAYLNYAWADYFRPPTMRDPAAALVKGSPAPLATQPVGVDLFPFPPAMTNLPSSGMLPPPGVFLPPNGLLPFPTHPADLALKSLPPELSLKNGMSPYDALRHLQNNVSPMDTSSARLSPTSSRQSGSPRSMANASPDRSKADSKSEVNSMHDATITDESDEEPIEVVKSAFHPTRPANVELQEMKRVQAADSTVADRPRVRSELKAHSQRTRVLSTSPTSTKLTNGTLSTHKSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00677312;
90% Identity: iTF_00649796; iTF_00826596; iTF_00913382; iTF_00825355; iTF_00044237; iTF_00895693; iTF_01207887; iTF_00648884; iTF_01208981; iTF_00142870; iTF_00033595; iTF_00935456; iTF_00390136; iTF_00818137; iTF_00250237; iTF_01172104;
80% Identity: -