Basic Information

Insect: Pyrausta despicata
Gene Symbol: run
Assembly: GCA_963921415.1
Location: OY992863.1:9831718-9839510[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.4e-71 1.5e-67 226.1 0.0 2 129 21 148 20 148 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.4e-71	1.5e-67	226.1	0.0	2	129	21	148	20	148	0.98

Sequence Information

Coding Sequence: ATGCACCTTCCACACGCGAGCCCCCCGGCCCCCAGCATGGCTGACGTGTATTCTCACATCCATGAGTACTACAGGCAGAGCCACGGCGAGCTGGTGCAGACAGGATCGCCGGCGGTGTTGTGTTCGGCGCTGCCTGGACACTGGCGGTCGAACAAATCGTTGCCATTGGCTTTCAAAGTCGTGGCTCTGGATGACGTTCAAGACGGCACGTTAGTGACAATCAAGGCTGGAAACGATGAGAATGTGATGGCAGAGCTGAGGAACTGCACCGCTGTGATGAAGAACCAAGTGGCCAAGTTCAACGACCTGAGGTTCGTAGGTCGCAGCGGTCGTGGGAAGTCGTTCTCGCTCACCATCACCATCAGCACCTTCCCTAGCCAAGTTGCCACTTACACCAAGGCCATCAAAGTCACAGTCGATGGACCCAGAGAACCTAGAACAAAACAaaATTACGGCTATGGCCACCCCGGGGCGTTCAGTCCATTCCTGCTGAATCCCGGCTGGCTGGATGCCGCGTACTTGAACTACGCGTGGGCAGACTACTTCAGGCCACCGCAGATGAACTCACCAGCATCTCTCGCTAAAGGAGCTCCACCGCTTGCAACGCCGCCTGTTCTGCCTGGGGCAGAACTATTCCCGTTCCCGACTGCCATTGCAAATATTCCTCCAGGAGGCTTAATACCGCCGCCTGGTGCGTTCCTGCCGCCGAATGGATTGTTGCCATTCACACCGCATCCTGCTGATCTAGCACTGAAAACGCTACCACCAGAGCTATCACTCAAAAACGGAGTCAACCCTTACGAAGCTTTGAGACACTTGCAAAGCAACGTTTCTTCAATGGACACGTCGAGCGCCCATTTATCACCGACCAGCAGTAGACAGAGCAGTCCGCGCAGTATGGCTAATGCTAGTCCCGACCGATCAAAAGCTGATTCCAAGTCTGAAGTGAATTCAGTTCACGACGCTACGATATCTGATGAATCCGATGAAGAGCCAATTGAGGTTGTGAAATCTGCATTCCATCCTACAAAGCCAGCCAATGTTGAGCTGCAGGAGATGAAGCGAGTACAAGCTGCGGATTCGACGGTCTCGGACAGGCCTCGGATAAAGAATGAATTGAAAGCTCCCTCACAGAGGACTACGCGAGTTCTTTCAACTAGTCCAACGTCAACCAAAATTAGCAACGGTGCGATATCAGGTCACAAAACAGTGTGGAGGCCATATTga
Protein Sequence: MHLPHASPPAPSMADVYSHIHEYYRQSHGELVQTGSPAVLCSALPGHWRSNKSLPLAFKVVALDDVQDGTLVTIKAGNDENVMAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTITISTFPSQVATYTKAIKVTVDGPREPRTKQNYGYGHPGAFSPFLLNPGWLDAAYLNYAWADYFRPPQMNSPASLAKGAPPLATPPVLPGAELFPFPTAIANIPPGGLIPPPGAFLPPNGLLPFTPHPADLALKTLPPELSLKNGVNPYEALRHLQSNVSSMDTSSAHLSPTSSRQSSPRSMANASPDRSKADSKSEVNSVHDATISDESDEEPIEVVKSAFHPTKPANVELQEMKRVQAADSTVSDRPRIKNELKAPSQRTTRVLSTSPTSTKISNGAISGHKTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00677312;
90% Identity: iTF_00364687; iTF_00075233; iTF_00076226; iTF_00960707; iTF_01125219; iTF_01281994; iTF_00408173; iTF_01071408; iTF_01281078; iTF_01124378; iTF_01279039; iTF_01502737; iTF_01503624; iTF_00006066;
80% Identity: -