Cnup037861.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Catocala nupta
Gene Symbol
run
Assembly
GCA_963675205.1
Location
OY776097.1:10350465-10358752[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3e-71 3.9e-67 225.5 0.0 2 129 21 148 20 148 0.98

Sequence Information

Coding Sequence
ATGCACCTCCCGCACGCGAGCCCTCCGGCCCCCACCATGGCGGACGTCTACTCGCACATCCACGAGTACTACCGGCAGAGCCACGGCGAGCTGGTGCAGACCGGCTCACCAGCGGTACTGTGTTCCGCGCTGCCGGGACACTGGAGGTCCAACAAGTCATTGCCGGTCGCCTTCAAAGTCGTCGCTTTGGATGACGTACAGGATGGCACTCTGGTCACTATCAAGGCTGGGAATGATGAGAACGCAATGGCGGAACTGAGGAATTGTACTGCCGTCATGAAGAACCAGGTTGCAAAGTTCAATGACTTGAGGTTTGTGGGCCGCAGTGGCCGTGGCAAGTCATTCTCGCTCACCATTACCATCAGCACGTTCCCAAGCCAAGTGGCCACCTATATCAAAGCCATCAAAGTCACTGTTGACGGCCCCAGGGAACCTAGAACTAAGCAAAATTACGGATATGGTCATCCCGGTGCGTTTAGTCCATTCCTATTGAACCCCGGCTGGCTGGATGCGGCGTACCTCAACTATGCATGGGCTGACTACTTCAGACCACCACAAATGCGTGATACGACCGCTGCACTTGTAAAAGGTGCCGCTGGCCCAATCACAACACCCCCTGTGACGTTGCCAGGAGCTGATCTGTTCCCGTTCGCACCAGCGATGACGAATCTCCCACCAGGTGGGCTAATCCCTCCCCCCGGTGCATTTTTGCCACCAAACGGGCTTTTGCCTTTCGCACCTCACCCAGCAGAGCTAGCTTTGAAGACGTTACCACCAGAACTAACACTTAAGAATGGCGTCAATCCATACGATGCTTTGAGACAGTTACAAAGCAACATGTCAATCGATACCTCAAGTGCTCGATTATCACCCACTAGCAGCAGGCAAAGCGGAAGCCCAAGGAGTTTGACAAATGCTAGCCCGGACAGATCGAAAGCTGATTCGAAATCTGAAGTTAATTCTATGCATGACGCAACGATCTCTGACGAGTCTGACGAAGAACCTATTGAAGTAGTGAAGTCTGCGTTCCATCCGACGCGGCCCGCGAATGTCGAGCTGCAAGAAATGAAGAGAGTCCAAGCTGCGGACTCCACCGTTGCGGATAGGCCAAAGGTCCGTAACGAATTGAAGGCGCCTTCCCAGCGCACCACCAGAGTGCTTTCAACTAGTCCAACTTCAACCAAAATCACAAACGGTGCGATACCAACGCACAAATCCGTGTGGCGGCCATATTGA
Protein Sequence
MHLPHASPPAPTMADVYSHIHEYYRQSHGELVQTGSPAVLCSALPGHWRSNKSLPVAFKVVALDDVQDGTLVTIKAGNDENAMAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTITISTFPSQVATYIKAIKVTVDGPREPRTKQNYGYGHPGAFSPFLLNPGWLDAAYLNYAWADYFRPPQMRDTTAALVKGAAGPITTPPVTLPGADLFPFAPAMTNLPPGGLIPPPGAFLPPNGLLPFAPHPAELALKTLPPELTLKNGVNPYDALRQLQSNMSIDTSSARLSPTSSRQSGSPRSLTNASPDRSKADSKSEVNSMHDATISDESDEEPIEVVKSAFHPTRPANVELQEMKRVQAADSTVADRPKVRNELKAPSQRTTRVLSTSPTSTKITNGAIPTHKSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00677312;
90% Identity
iTF_00677312; iTF_00284298; iTF_00074251; iTF_00035414; iTF_00278886; iTF_00382343; iTF_00751799; iTF_00621796; iTF_01534564; iTF_00038465; iTF_00785793; iTF_01028033; iTF_00147074; iTF_00711586; iTF_01063522; iTF_01416546; iTF_01487490; iTF_00907651; iTF_01083075; iTF_00851492; iTF_00042405; iTF_01029925; iTF_01092837; iTF_01285318; iTF_01526790; iTF_00120263; iTF_01246599; iTF_01525703; iTF_00124008; iTF_01361352; iTF_00446889; iTF_00449897; iTF_01192393; iTF_01341993; iTF_00049674; iTF_00784170; iTF_00326859; iTF_00036396; iTF_00924364; iTF_01119052; iTF_01230284; iTF_01264172; iTF_01415596; iTF_00039565; iTF_00784973; iTF_01084909; iTF_00037550; iTF_00111374; iTF_00300942; iTF_01094670; iTF_01116942; iTF_01259854; iTF_00122127; iTF_00373679; iTF_00928431; iTF_00951567; iTF_01533711; iTF_00301872; iTF_00906832; iTF_01118032; iTF_00041553; iTF_00121169; iTF_00176881; iTF_00444881; iTF_01025745; iTF_01084017; iTF_00071186; iTF_00299923; iTF_01093811; iTF_01339731; iTF_01439667; iTF_00123124; iTF_00685204; iTF_01221268; iTF_01338260; iTF_00040565; iTF_00043253; iTF_00172501; iTF_00887989; iTF_01362869; iTF_01424821; iTF_00745398; iTF_00973494; iTF_01064406; iTF_00425143; iTF_00448791; iTF_00622583; iTF_00757911; iTF_01061655; iTF_00237240; iTF_00363801; iTF_00667130; iTF_00830938; iTF_01030906; iTF_01440762; iTF_01531738; iTF_00445883; iTF_00017116; iTF_01377244; iTF_00000093; iTF_00905885; iTF_01028989; iTF_00374942; iTF_00850366; iTF_00783199; iTF_00952479; iTF_00017952; iTF_00383392; iTF_00771648; iTF_01027072; iTF_01062528; iTF_01076160; iTF_01532800; iTF_01362275; iTF_00809831; iTF_00273386; iTF_00274220; iTF_00808877; iTF_00818920; iTF_00006858; iTF_01251527; iTF_00171530; iTF_00726059; iTF_00027533; iTF_00072046; iTF_01538514; iTF_00185912; iTF_00026617; iTF_00185083; iTF_00819835; iTF_00888966; iTF_00930996; iTF_00794093; iTF_00821551; iTF_00967827; iTF_01173047; iTF_01073382; iTF_00761401; iTF_01436790; iTF_00063354; iTF_00858317; iTF_00787395; iTF_01358661; iTF_00290440; iTF_01429708; iTF_00341109; iTF_00859232; iTF_01151834; iTF_00869397; iTF_00000957; iTF_00790973; iTF_00790018; iTF_00932190; iTF_01010142; iTF_00806464; iTF_00994144; iTF_00674086; iTF_01401056; iTF_01332319; iTF_01491648;
80% Identity
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