Basic Information

Insect: Drosophila novamexicana
Gene Symbol: RREB1
Assembly: GCA_003285875.3
Location: NW:224488-236576[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0052 0.27 11.3 0.6 1 21 247 267 247 269 0.96

2 13 0.00029 0.016 15.2 0.2 1 23 279 301 279 301 0.98

3 13 7.1e-05 0.0038 17.1 7.3 1 23 307 329 307 329 0.98

4 13 0.45 24 5.2 1.7 2 20 550 568 550 570 0.93

5 13 0.0078 0.41 10.7 0.1 1 23 712 734 712 734 0.97

6 13 1.1e-05 0.00058 19.7 0.7 1 23 744 766 744 766 0.99

7 13 0.00073 0.039 14.0 2.0 1 23 772 795 772 795 0.97

8 13 0.0026 0.14 12.2 2.0 1 23 1056 1079 1056 1079 0.95

9 13 7.6e-05 0.004 17.1 0.3 2 23 1426 1447 1425 1447 0.97

10 13 0.13 6.8 6.9 6.3 1 23 1453 1476 1453 1476 0.97

11 13 8.3 4.4e+02 1.2 3.4 1 23 1593 1616 1593 1616 0.78

12 13 0.0074 0.39 10.8 0.5 3 23 1679 1699 1677 1699 0.96

13 13 0.0012 0.063 13.3 4.8 1 23 1705 1727 1705 1727 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0052	0.27	11.3	0.6	1	21	247	267	247	269	0.96
2	13	0.00029	0.016	15.2	0.2	1	23	279	301	279	301	0.98
3	13	7.1e-05	0.0038	17.1	7.3	1	23	307	329	307	329	0.98
4	13	0.45	24	5.2	1.7	2	20	550	568	550	570	0.93
5	13	0.0078	0.41	10.7	0.1	1	23	712	734	712	734	0.97
6	13	1.1e-05	0.00058	19.7	0.7	1	23	744	766	744	766	0.99
7	13	0.00073	0.039	14.0	2.0	1	23	772	795	772	795	0.97
8	13	0.0026	0.14	12.2	2.0	1	23	1056	1079	1056	1079	0.95
9	13	7.6e-05	0.004	17.1	0.3	2	23	1426	1447	1425	1447	0.97
10	13	0.13	6.8	6.9	6.3	1	23	1453	1476	1453	1476	0.97
11	13	8.3	4.4e+02	1.2	3.4	1	23	1593	1616	1593	1616	0.78
12	13	0.0074	0.39	10.8	0.5	3	23	1679	1699	1677	1699	0.96
13	13	0.0012	0.063	13.3	4.8	1	23	1705	1727	1705	1727	0.99

Sequence Information

Coding Sequence: ATGCTGGccgcacagcaacagcagcagccacaacagcaacacacaacggcaacagcagcggcaggcaCAACAGTAGGGCTCGAGGATGCGGGCTTGGAGCGGGCGCGCCGCGATTCGAGCACGTCGGAGTCCTCGCTGGAGCACCTGGACTTGAGCCGCACGCCAAAgaagctgagcagcagcagcggcgcgcCGCagccgacgtcgacgccgcACGAGGCGACGTCGCGCAAGCGCAAactgcgccagctgcagcagcagccgcaacagttGCTCTCCGACGAGGatgaggagcagctgcagcagcagcagcaacagcagcagcagcagctgctggagcagTCCGCGCAGCGACTGCGGCACAAGCAGCGACGCAGCGGAAGtgcagccgcagtcgctgccgcagctgctgccagcgccAGCATCGTCGTCGACTACAGCGCCGGCGGCGATGCCAGTTCGCTGCGCAAAAAGTTTCGCCTGAACCGCAGCAGCGCGAGCAGCATCAATGGCAACAACGGGGAGCTCTCTGAGTCCGGCTTTGTGGATGGCAGCGCGCACAGCGGCTATTTGCTCAGCGCCAGCAGCGCGGCGCAGTCAGCGtcggcagcgcagcagcagcaacagcagcaacagcagcaattggcCTCAAGCAGCAGCTCCGGCGGCAGCTCGCCCCAAGGCCTGTGCCACTCGAGCGCCGAATCCGGCATCGGCGCCGGCGACGAGCACATGAAATATGTTTGCCCCATCTGCGAGGTCGTCTCGGCCACGCCCCACGAGTTCACCAATCACATACGTTGCCACAACTACGCCAACGGCGATACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTATCATCGGCCTCCTCGCTGGACAGACACGTGCTGGTGCACACGGGCGAGCGTCCGTTCAACTGTCGCTATTGCCATCTGACATTCACGACGAACGGCAACATGCACCGGCACATGCGCACCCACAAGCAGCACCAGacgacgcagcagcagcagccgacgcagcagcagcagcaacaggcacagcaacaacatgcacCGCAGCAAcatgcacagcagcaacatgcacagcagcagcagcagcgacggcagcaaCATGCGGGCGCGTCAGCTGGACGCGCGGAGAGCTACGAGAGCGATGCCAGCTGTTCGACGGATgtgtccagcagcagcagcggcagcagcagcaacaacagcaacaacagcaacaataacaacaacaacaacaacaacaacaacagcgagcaaacgaacaagaacaacagcaacagcaacggcgagcagcagcagcagcaactgttgctggcgTGCAAGCAACGACGGCCGAAGacaaacatcaacaacaacaacattctcAGCGACGAGGAGCAGCCAAAGCAGCCCAAGTCGGAGCCCGAGCCGGAGCCAGATCTGGActcggatgcggatgcggagaGCGTGGATGTGGCACAAATGATCACGAGCACGCCGGATGTGGCCACATTGTTGGCCaccggcggcgtcggcggcagCACGCCGAGTCCCTCGCCGGGGCTGCAGAGCTGTCCGGCGTGCAATACGGGCGAGTTTGAGACATTGCCGGCGCTGTGCGCGCATCTGGATGCAGCGCATCCGGACATACCAGCCAAGTGTCGCGAGTGCGAGGTGATCTTTGCCAGCCATCGGCAGCTGCAGGTGCACAGCTGTCgcggccagctgcagctgccgccgctgctgggCGCCAGCAGCTCGCCGCTGCACAAGCTGGAGGAGCACGAGCACGACCAGgagcagccggagcagcagcagtatggggatgaggaggaggaggaggagcagctggcCAGCAGCGAGCGGGATGAGTTCTTTCAGCAGCTCTATCTAAAAGGCAAGGCCGGCGGCCTGCCGTCGCCCATCAAGCGGGAGCCGTCGGAGCAGCGTCAGGATCTGGCCGATATACAGAGCATACTGCACATGACCAGCTCCAGCTGTACGTCGAGTTTCCTGCGCAACTTCGAGCAGTCCGTGAACACGCCTTGCTCCAGCCAGTACAGTCTGGATGGGCGCGACGGCGAGGAGGAGGCCCAGGATGCGTTCACCAGCGAATTCCGGCGCATGAAACTGCGCGGCGAATTTCCCTGCAAGCTGTGCAGCGCCGTCTTTCCCAATTTGCGCGCCCTCAAGGGCCACAATCGTGTCCATTTGGCCGCTGTCGGCGCCGCCGGACCCTTTCGCTGCAACATGTGCCCCTATGCCGTTTGCGACAAGGCGGCGCTGGTGCGGCACATGCGCACCCACAACGGAGATCGGCCGTACGAGTGCGCCGTCTGCAATTATGCATTCACCACGAAGGCCAACTGTGAGCGGCATCTGCGCAATCGACATGGCAAGACGAGCCGCGAGGAGGTTAAGCGCGCCATTGTCTATCATCCGGCGGAGGATGCCAGCTGTGAGGAGAACAACAAACGGGCCGCGGGCCAGGACACGGATCTGGCCGAGCTCAGCTATCGCTCGCTCAGCCCGCCACCGCCGCTTCCGCTTCCTTTGCCGCCGCCGGCGACGGAGTCGCAGCTGAAGCACATGTTGCTCGCGGAGCCGTGCGCCAAGCCGCCGCCAACGGCGCCGGCAACGCCGCTCAAGATACAGGTGAAGAGCCTGGATCAGCTGGTGGAGAAACCGGTAGCGCCGCCGGCCATGGATCTCAGCATGGACGTGCTGGATCTGAGCAAGAAGCCCACACAGCAGCTGGAGCGCCAGCGGGAACGGGAACGCGAACGTGAGCAGGAGCAcgagctgctccagctgcagcagcaacaggtgcaacagctgcaacaggtgcaacagcagcagcagcagcaactgtttgGAGGTGATGCGACCACGCAGTatatgcagcagctgctgcgcaatCTCATGTTCCAGCAGACGCCGGGCTTCTCCTTCTTTGGCTATATGGCGCCTCCGCCGCCGGCAACGGCGACGACAGCAACAGATAAATCCCAAGCAAATGCAGCTGCGACGccggcaacagttgctgccatGCCCGTGCCCATGCCCATGGCCGTGCCGGTGCCCGTGCCAGCTGGCGGACCCGTCAAGATGGTCATCAAGAATGGCGTCCTGATGCCCAAGCAGAAGCAGCGTCGCTATCGCACCGAGCGTCCCTTCGCCTGCGAGCATTGCTCCGCCCGTTTTACGCTGCGCTCCAACATGGAGCGCCATgtgaagcagcagcatcccCAGTACTATGCGCAACGCCAGCGCAGCGGACACCATGTGATGCGCGGACGCGCGGCCAGCTCCaatgcggcggcggcggcagcggcagcggcggcagcagcagcagcagctgccatgtCGAATCTGgcgcagcaccagcagcaacagcagcagcagcagcatgcgcATCCGCCCATCTCGGAGCAGGTGAAGTATGCGATATTGGCGCAGCAGCTGAAGGCGCGCAAGGATACGGATCTGTTGCAGCAGGCGCTGGCGCACGGCTCCAGCAGCGCGCTGCTCCACTTtaactacaataacaacaacaacaagcaggagcagcagcagcaacagcagccacatccCGGCAACAATCTGAACGGAGCTGCTGCGGATGACGATGAGCCGCCCAAGCTGATCATAGACGAGGACGATGAGGTTGAGGAGGAGGAGTTTGACGATACGGAGGAAGAACCGGAGGAGGAGCTCGAAATGGAGGAGGATGACGAGGAGCAGGCGGAACAGCTGATGGAGTCCGCGTtggcggccacgcccacattgcCACGCCCCGGCACGCCAATTGAGGCAGCCAAAAAGGTAGCGGAGAGCATACTGGAGCAGGTGATCAAGGCGCAGGCCAAGCCCGATCCCGAttccgatgccgatgccgtgGCCATGCCAACgcccacaacagcagcagcatcagcagtagccacgcccacgccaacGCCCACTACGATGAAAACAATGATAGCCCAAGCAGAATCGGTGGCCAAATCCTTGAAAGATGTGGCCAGCTCGCCGTTCAAGGACGAATCTCAGGATCTGGTGCCGGTGGCCAAGCTGGTAGACAACGCGACCAGCAATCAGGTCTCCTTCAATAGCTATTTCCGGCCAAGCGACGTGGCCAATCACATGGAGCAGAGCGACGAGGAGGGCCTAGTCGCCTCCGGCAGCGCCAGCGAGAGCAACAATTCCGGCACCGAGGACgtaaccagcagcagctgcaacgaACCAAAGAAGAAGTCCGCCTACAGTCTGGCACCGAATCGTGTCAGCTGTCCGTATTGCCAGCGCATGTTCCCGTGGAGCAGCTCGCTCCGGCGCCACATTCTCACCCATACGGGCCAGAAGCCCTTCAAGTGCTCCCACTGTCCGCTGCTGTTCACCACGAAGAGCAACTGCGATCGGCATCTGTTGCGCAAGCACGGCAATGTCGAGTCCGCGATGAGCGTCTATGTGCCCACCGAGGATGTCAGCGAACCGATACCCGTGCCCAAGTCCGTCGAAGAGATCGCCCTGGAGGAGCAGCGCCGCCGCAAGGCAGCCGAGGCGGAGCGCGAAAGGGAACGCGAaagggaacgggaacgggaacgcgAGCGGGAACGCGAAAGAGAGCgtgaacgggaacgggaacagcagcagcagctcatccaGCAGCTGACCGCCGCGGCACAGCTGCGCCAGCAActggccgccgccgccgccgtcgctgcaGCTGGACCCGGTGCTGGGAATAGTCCAACTGGAGGGGAAGGAAACGGCAGCGAGCTGCCGTACAAATGCCATCTGTGCGAGTTCTCGTTCGGCGAGCGGCTGCAGTGCCTCGAGCACATCAAGCAGCTGCATGGCCAGGAGTTTgccctgctgctggccaaaggCGCCATCGAAACGGAGGCGCTCCacgaccagcagcagcagcccaatcctcagcagcagcagcccctgGCAACAGCTGGTTCCGAGGATGAGTCGCTGGCGCCGGCGGGTCGCGGCAATGGCAAATATCCGGACTACAGCAACCGGAAGGTGATTTGTGCGTTCTGTGTGCGTCGCTTCTGGTCAACGGAGGATTTGCGGCGACATATGCGCACACATTCCGGCGAAAGGCCGTTCCAGTGCGAGATCTGTTTGCGCAAGTTCACGCTGAAGCACAGCATGCTGCGGCACATGAAGAAGCACAGCGGACGCAGTCACAATGGCGAGCAGGGCGCCTCCGATTGTTCCGATGACGAGCAGATGGCCACGCCACCTGGCACGCCCACTCCAACGCCCCAATCCATGGCCATGcccagcaataacaacaacaacaacaacaacaacagttgccagaacaacaacaacaagcagagcCTGCGCCTGGACAAGACGCCCGACTGGCGCCTCCAGAAGGACAAAATGGGCGATGCCACGCCCTcagctggaggaggaggaggagcagcagccgcagcagccgccgccgccgcctttgGCATGGCCAGCAACGATCTAATTGGCAATCTGCTGGGCATCAGCGACCAGGGCATACTCAACAAGCTGCTCTCCTCCGCGGACGAGGCGGCCAAGCTGCTGGGCGTTGAAAAGTAA
Protein Sequence: MLAAQQQQQPQQQHTTATAAAGTTVGLEDAGLERARRDSSTSESSLEHLDLSRTPKKLSSSSGAPQPTSTPHEATSRKRKLRQLQQQPQQLLSDEDEEQLQQQQQQQQQQLLEQSAQRLRHKQRRSGSAAAVAAAAAASASIVVDYSAGGDASSLRKKFRLNRSSASSINGNNGELSESGFVDGSAHSGYLLSASSAAQSASAAQQQQQQQQQQLASSSSSGGSSPQGLCHSSAESGIGAGDEHMKYVCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQTTQQQQPTQQQQQQAQQQHAPQQHAQQQHAQQQQQRRQQHAGASAGRAESYESDASCSTDVSSSSSGSSSNNSNNSNNNNNNNNNNNSEQTNKNNSNSNGEQQQQQLLLACKQRRPKTNINNNNILSDEEQPKQPKSEPEPEPDLDSDADAESVDVAQMITSTPDVATLLATGGVGGSTPSPSPGLQSCPACNTGEFETLPALCAHLDAAHPDIPAKCRECEVIFASHRQLQVHSCRGQLQLPPLLGASSSPLHKLEEHEHDQEQPEQQQYGDEEEEEEQLASSERDEFFQQLYLKGKAGGLPSPIKREPSEQRQDLADIQSILHMTSSSCTSSFLRNFEQSVNTPCSSQYSLDGRDGEEEAQDAFTSEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRVHLAAVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREEVKRAIVYHPAEDASCEENNKRAAGQDTDLAELSYRSLSPPPPLPLPLPPPATESQLKHMLLAEPCAKPPPTAPATPLKIQVKSLDQLVEKPVAPPAMDLSMDVLDLSKKPTQQLERQREREREREQEHELLQLQQQQVQQLQQVQQQQQQQLFGGDATTQYMQQLLRNLMFQQTPGFSFFGYMAPPPPATATTATDKSQANAAATPATVAAMPVPMPMAVPVPVPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQYYAQRQRSGHHVMRGRAASSNAAAAAAAAAAAAAAAAMSNLAQHQQQQQQQQHAHPPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSALLHFNYNNNNNKQEQQQQQQPHPGNNLNGAAADDDEPPKLIIDEDDEVEEEEFDDTEEEPEEELEMEEDDEEQAEQLMESALAATPTLPRPGTPIEAAKKVAESILEQVIKAQAKPDPDSDADAVAMPTPTTAAASAVATPTPTPTTMKTMIAQAESVAKSLKDVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSCNEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIALEEQRRRKAAEAEREREREREREREREREREREREREREQQQQLIQQLTAAAQLRQQLAAAAAVAAAGPGAGNSPTGGEGNGSELPYKCHLCEFSFGERLQCLEHIKQLHGQEFALLLAKGAIETEALHDQQQQPNPQQQQPLATAGSEDESLAPAGRGNGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGEQGASDCSDDEQMATPPGTPTPTPQSMAMPSNNNNNNNNNSCQNNNNKQSLRLDKTPDWRLQKDKMGDATPSAGGGGGAAAAAAAAAAFGMASNDLIGNLLGISDQGILNKLLSSADEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00531137; iTF_00617091; iTF_00506310; iTF_00526770; iTF_00490966;
90% Identity: iTF_00506310;
80% Identity: -