Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00018 1.2 9.5 0.0 16 48 78 110 64 114 0.81

2 7 0.0085 58 4.1 0.1 22 45 115 138 111 146 0.83

3 7 0.032 2.2e+02 2.3 0.6 18 45 139 166 134 169 0.81

4 7 0.003 21 5.5 0.3 16 45 165 194 152 197 0.85

5 7 0.00055 3.8 7.9 0.4 18 44 195 221 193 224 0.92

6 7 0.00094 6.4 7.2 0.1 21 44 226 249 221 254 0.89

7 7 0.0066 45 4.5 0.2 21 44 254 277 252 283 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00018	1.2	9.5	0.0	16	48	78	110	64	114	0.81
2	7	0.0085	58	4.1	0.1	22	45	115	138	111	146	0.83
3	7	0.032	2.2e+02	2.3	0.6	18	45	139	166	134	169	0.81
4	7	0.003	21	5.5	0.3	16	45	165	194	152	197	0.85
5	7	0.00055	3.8	7.9	0.4	18	44	195	221	193	224	0.92
6	7	0.00094	6.4	7.2	0.1	21	44	226	249	221	254	0.89
7	7	0.0066	45	4.5	0.2	21	44	254	277	252	283	0.84

Coding Sequence: ATGGATCAAGTGATAGATGTGGGCTGCGTTAAGGAGGAGCACTGTGAGGCAATATGCAATATGTTTAGAGCACAAGATTGGCAACTAGCGATGAGGCACAGGGACTTGGGACTCGTTAAAGTAGAGCAGGATATGAGCATTGTGTGGCAAGGCACCAGCAACGGGATATTAGAGAACAAGGAGCGACACCCAGAGAAGCAAAAGAAATTAAACAATGGTGTCAAATCGCAGTTCAGTGTAGCTATTATTGAGAAACCATTCAAGTGTCCACATTGCATAAAGGACTTTGCCACCAGCAGTAACCTAAAAGTTCATCTATCACGCACTCACGCTGGAGACCAAGACCGTCCCTTTGTGTGTCCCACTTGTCCAAAGTCATTTGCCACAAACGACAATCTACAGAAGCACATCCGCAGGCATTCAAATGAGCGAACTCTGAACTGTCCCCACTGTCCAAAGGCTTTCGCCACCAAGGATAATCTGCAGAAACACATTCGCAGACATTCAAGCGAACGCACTCTGATATGTCCTCACTGTCCAAAAGCCTTTGCCACAAATGACAATCTCCAGAAGCACATACGCAGGCATTCTAGCGAAAGAACTCTTCAATGTCCGCTTTGCCCGAAAGCCTTTGCTACAAATGATAATCTCCAGAGGCACATACGTGGTCACACCGGTGAACGGCCTTTCAAGTGTCCATACTGTCCAAAACCATTTGCCCAAAACCGGGATCTGAAAGCACACATTCTGGAGCACACAGGCGAAAAGCCCTTCAAATGTCCACACTGCCCGAAAGCCTGTGTAAGAAGCGAAGGACTTAAAAAGCATATACTACGACTACACAAAGACATTGATCCTGAGCCAGCACAAGCGTCAAGCAACACTTTGTCCAAACAATGGCAAGCTTCCGACTCCAGTGGCAGAAtctttatgtataaatatgatCTGACCAAGCAAACACGAATGCCCACCGGCGAGGCGTAA
Protein Sequence: MDQVIDVGCVKEEHCEAICNMFRAQDWQLAMRHRDLGLVKVEQDMSIVWQGTSNGILENKERHPEKQKKLNNGVKSQFSVAIIEKPFKCPHCIKDFATSSNLKVHLSRTHAGDQDRPFVCPTCPKSFATNDNLQKHIRRHSNERTLNCPHCPKAFATKDNLQKHIRRHSSERTLICPHCPKAFATNDNLQKHIRRHSSERTLQCPLCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHILRLHKDIDPEPAQASSNTLSKQWQASDSSGRIFMYKYDLTKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00544875;
90% Identity: iTF_00608583; iTF_00558060; iTF_00583839; iTF_00601957; iTF_00601965; iTF_00533974; iTF_00533980; iTF_00507015; iTF_00523084; iTF_00507021; iTF_00523091; iTF_00585354; iTF_00585348; iTF_00537647; iTF_00537640; iTF_00586099; iTF_00586094; iTF_00510681; iTF_00528965; iTF_00519317; iTF_00575741; iTF_00575736;
80% Identity: iTF_00558060;