zf-GAGA
- Domain
- zf-GAGA domain
- Group
- Zinc-Coordinating Group
- PFAM
- PF09237
- Desciption
- Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
- Rederence
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- The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. Omichinski JG, Pedone PV, Felsenfeld G, Gronenborn AM, Clore GM. Nat. Struct. Biol. 4, 122-32, (1997).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
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