Dmur010355.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila murphyi
Gene Symbol
Znf639
Assembly
GCA_018904325.1
Location
JAEIFX010001255.1:12855921-12859137[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.014 0.96 9.9 0.4 3 23 312 333 311 333 0.91
2 10 0.00015 0.01 16.1 0.5 6 23 342 359 342 359 0.99
3 10 8.9e-06 0.00062 20.0 0.3 1 23 365 388 365 388 0.98
4 10 0.00012 0.0085 16.4 0.5 1 23 400 422 400 422 0.98
5 10 0.0003 0.021 15.2 7.7 1 23 429 452 429 452 0.96
6 10 1.3e-05 0.00086 19.5 1.8 1 23 458 480 458 480 0.96
7 10 0.31 22 5.7 0.9 2 23 489 510 488 510 0.96
8 10 0.00012 0.0082 16.4 2.8 2 23 516 538 515 538 0.95
9 10 1.9e-07 1.3e-05 25.2 0.7 2 23 545 566 544 566 0.97
10 10 0.00019 0.013 15.8 4.4 1 23 572 595 572 595 0.96

Sequence Information

Coding Sequence
ATGATCTGTCGCTTGTGTTTAAAAAGCATAAACGCAAACAATGCTGTCTATCTGTTCGAAACGAACGACACCCTGGCCGAATCCTCGCTGCTCAAGATAATAGCCAAGTTTCTGCAGCTGGAGATAATGCCCGATGACAACATCTCGACGAACATTTGCCATGATTGCTGTGAACATTTGGAGGACTTTAACAACTTCTGGCAGCTGGTCGAGCAAAAGCAGTTAACGCTTAAAAAGGAGTTCCTCAACGTGGACGTCGATTGCGTGGCCCTCAAATGGACGGGCGGTATCGATGTGGATGTCAATATAGATGAGCTGCCGCTGGTCACCGACGAGATGGACGAGAAGCCCCTCGATATACACAATCTCAGTCTGCTTGGCAGCGTTCTCGATGTGAATGTGGACAGTGTGGAGGTGCCGCAGCTGCATGCTGCACCAAAACATTTGCATAACCCCGACCAGCTGCTGCCCCTGCACGTCTTCAATCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTGAAAAGCCCATAATGAATGAGAGCAGCGATAGCACGCCGCACACTTCCTCAGATGATGATGATGAAGTGCCTCTGGTGAAGCTGAAGCACAAGCTCAAACCAAAGCGGAAGGGACGCATTGTGGCACGCAATGAGCAGCGCCGGCTAACGCTCGCCCAGGAGCTGAATCAGCTGCTGGATGATACCGACACTGGATGCGACAATGATAACGATGGCGATAGCGTCAATCGAGGGCGTCGCAAACAGCGGAACACAAACAGAAACACAAACACAAATAATAATGCGCCAACGGATACACAGAAGAGCGAGCTGCAGGCGGCCATGGAACGAAAGCCGAAGGGCTGCTCACGGGCGCAGCTATCGAAGCGTTACGAGGAGGCCATCGCCAGCTATATGAATGCCGACTGTGATCTGTGCGACTTCAGCACCAAGTACCTGTCCCAGTTGAAGGTCCACTTCCTGGAGGTGCATCAGCGCGACGCGTATCTCAAGTGCTGCAACAAGGTCTTCAATCGCGCCTCCAAACTGATGGATCACATACGCAAGCACATCAATCCCAAGCTATTCACCTGTTCGATTTGCAACAAGTCGCTAAATTCCCAGGATTATCTGGCCACGCACATTGAGACGGTGCACAACAAGGTCGCCCAGATTGGCAAGGTGCTGAAGTATCCGTGTCCGAAATGCGAGCGCACCTTCAGCAGCGAGAGGCGTTTGGGTAATCATTTGCTGAAGCACGACACGGATCAGTTGGAGCACAGTTGCCACATATGCCACAAGAGCTTTGCGAATGTGCATCGACTACGTCGGCATATACAGTCGATCCATGAGGATGTGCATCCGCATGTCTGCGACATTTGTGGCAAGAAGTTCAAGTTTAAGCCATCGTTCGAGCGCCACTTGCTGGAACACCAGGGCGTCGTCGCACCAGCGATGGAGTGCTCCGTCTGCGGTGTCTGGCTGAAGAACGAGCACAGTCTGCGCCTGCATCGATTTACGCACGATAGCACCGATACCGTCTGTCCCCATTGCTCCAAGACGTGCAGTTCGCGGACAGCGTTGCGCGCCCATGTTAAATATGCTCACAAGCTGACCACAAACCTGCAGTGCACGTACTGCGAGAAGAGCTTCAAGCAGCAGCGCAACCTCGAGGAGCACATGGCGATACACACTGGCCTCCAGCTATACAATTGCCCCCACTGTCCCAAGGAATGCAGGTCGCGCTCCAACATGTATGTTCACATCAAGCAGAGGCATGCGGACGAGTGGCTCAAGGCCAAAATGGCACGCTCCCATAATCCGCAGTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTATTAAGTAGTCGCTAG
Protein Sequence
MICRLCLKSINANNAVYLFETNDTLAESSLLKIIAKFLQLEIMPDDNISTNICHDCCEHLEDFNNFWQLVEQKQLTLKKEFLNVDVDCVALKWTGGIDVDVNIDELPLVTDEMDEKPLDIHNLSLLGSVLDVNVDSVEVPQLHAAPKHLHNPDQLLPLHVFNXXXXXXXXXXXXXXEKPIMNESSDSTPHTSSDDDDEVPLVKLKHKLKPKRKGRIVARNEQRRLTLAQELNQLLDDTDTGCDNDNDGDSVNRGRRKQRNTNRNTNTNNNAPTDTQKSELQAAMERKPKGCSRAQLSKRYEEAIASYMNADCDLCDFSTKYLSQLKVHFLEVHQRDAYLKCCNKVFNRASKLMDHIRKHINPKLFTCSICNKSLNSQDYLATHIETVHNKVAQIGKVLKYPCPKCERTFSSERRLGNHLLKHDTDQLEHSCHICHKSFANVHRLRRHIQSIHEDVHPHVCDICGKKFKFKPSFERHLLEHQGVVAPAMECSVCGVWLKNEHSLRLHRFTHDSTDTVCPHCSKTCSSRTALRAHVKYAHKLTTNLQCTYCEKSFKQQRNLEEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADEWLKAKMARSHNPQFXXXXXXXXXXXXXXXXXXXXXXXXLSSR