Dhel021258.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila helvetica
Gene Symbol
IBTK
Assembly
GCA_963969585.1
Location
OZ018404.1:20194222-20198206[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.4e-08 5.9e-06 26.8 0.1 6 78 555 623 550 634 0.86
2 3 1.3e-13 3.3e-11 43.8 1.7 8 107 690 794 683 797 0.86
3 3 0.55 1.3e+02 3.2 0.2 63 109 784 828 780 829 0.83

Sequence Information

Coding Sequence
ATGTCAACTGCCAAGGCCCAGGAATATGACTGCACTGCCAAGTGTACATGTCGCCAGCATGGAAACTGCATCACAGCCGCACTTACAAAGCGCTCAATCGACAATCAAAATCTGGGAGCGTTTATCTTCAAGACTTGCGGAAATTTCGCCAACATCATAGATGACCTGGGCCGCTCTGCAGTGCACATGTCGGCTTCGGTGGCGCGATATGAGATTCTGGAGTGGCTATTGAACCACGGGGCTTACATTAACGGACTCGACTACGAGTCTGGCAGTAGTCCCTTGCACAGGGCCCTGTACTACGGCTCCATAGACTGTGCTGTGCTCCTGCTGCGCTATGGCGCAAGCCTGGAACTCCTAGACGAGGACACACGGTGTCCGCTGCAAGCCATCTGCCGCAAATGCGACGAAGATTTCACCACAGAGTCGCAGAACGATGTTCTCGTCTGGGGCTCCAATAAGAACTATAACCTCGGCATTGGCAACGAGCAGAACACCAATGCTCCTCAGGCGGTGGATTTCTTTCGGAAGTCCAACATCTGGATAGAGCAAGTAGCATTGGGGGCCTATCACAGTCTATTTTGCGACAAGAAGGGTCATCTCTATGCCGTCGGCCATGGCAAGGGCGGACGTCTGGGCATTGGCGTGGAGAACAGTTTGCCGGCTCCGAAGCGTGTGAAGGTCTCCTCGAAGCTGAACGACGATTCCATCATGTGCATAAGTGTCTCCCGACAACACTCTCTGCTGCTCACGCATCGTTCGTTGGTGTTTGCCTGCGGCATCAACACCGACCATCAGCTGGGAGTGCGTGATGCGCCCGAGAATCTGACGCAGTTCAGGGAGGTTGTCGCATTGCGTGACAAGGGGGCCAGCGACCTGCTGCGTGTGATCGCCTGCGATCAGCACTCCATTGCCTACAGCACCAAGTGTGTGTACGTCTGGGGTGCCAATCAGGGGCAATTTGGCATAAGTCGCAGCACAGACGCTATTATGGTGCCCACATTGATAAAACTACCTGCGCGCACTTCAATCCGTTTTGTGGAAGCCAACAACGCAGCTACGGTAATTTACACAGAGGAGAAGATAATTACTTTATTTTATGGCGACAAGACTAGATACATTAAGACTCCAAACTACGAAGATCTCAAAAGCATTGAGGTGATGGGCGGCCATTTAAAGAACTCCGTGAAAGGATCTGCAGCAGCCCTAAAGTTACTGATGCTCACCGAGACGAATGTGGTGTTCCTGTGGTACGAGAACACACAGCAATTCTACAGGTGCAATTTTTCGCCAATACGCTTGCCTGAGATTAAAAAGGTCCTGTACAAGTGCAATCAAGTCCTGATATTGTCTTTGGACGGCTGCGTCTATCGTGGCAAGTGCAATCAGATAGCCCTGCCAGCCAGCATGCTGGAAGAGAAATCCAAGCCCAATCTGGATATATGGCACAACAATGATCAGAATCGCACGGAGATTTCGAGAGAGCATGTGATCCGCATCGATCTGCAGCGTGTGCCCAACATTGATCGTGCCACCGATATCTTTTGCGACGAGAGCTTCTCCTCGTTCGCCGTGCTGCAGGAGTCGCACATGAAGTACTTCCGCAAGCCTCCATTGCCACGCAGGGAGCACAACTTCAAGAAGCTCTACCATGACACCTGTGAGTCGGATGCCGTGCACGATGTCGTCTTCCATGTGGATGGGGAGCGCTTTGCGGCCCACAAGTTCATCATCTACAGTCGGGCACCAGGCCTCAGGGAGCTCACTCGCATCTACTTGGACAAGAATGTCTATCTGAACTTTGAGAATCTCACAGGCAAGATGTTTGAGCTGATCCTAAAGTATATCTACACCAGTTACTGGCCAACGGAGGATGATATTGACTGCATCCAGGAGAGTCTGGGACCCTCCAACCCTCGGGAGCGAAGTCGAGCCTGCGAAATGTTTATCCCGCACTTGGAGACGTTTCAGCTGGTCGATCTAGCCAGATACTTGGAGAGCTACGTACGAGATAATCAATTTCCCCTGCCTAGTGCCCGGCAGCGTTTCAATCGGCTGCATCGCTCAGACTATCCAGAGCTCTACGATGTGCGAATCGTGTGCGAGGACTCGACAGTTCTGGAGGCCCACAAATGCATGCTGGTGTCGCGCTTGGAGTACTTTGAAATGATGTTTATGCACTCGTGGGCCGAGAGCACCACGGTGAACATGGAGGGAGTGCCCGCTGAGTATATGGAGCCAGTTCTGGACTATCTCTACAGCCTGGACACGGAGGCATTCTGCAAGCACAATCATTCGGAAACCTTTCTCTACAACATGATCACGTTCTGCGATCAGTACTTCATTGAATCGCTGCAGAATGTGTGTGAATCACTCATTCTGGACAAGATCAATATACGCAAGTGCGGCGAGATGTTGGACTTTGCCGCGATGTACAACTGCAAGCTGCTGCACAAAGGATGCATGGACTTCATCTGCCACAACCTAGCCAGAGTCCTCTGCTACCGCAGCATCGAACAGTGCAATGAGGCGACTCTCAAATGCCTCAACGACCATTACCGTAAGATGTTCTCCAATGTCTTCGACTACCGCCAGATCACGCCCTTCTCAGAGGCGATAGAGGATGAGCTGCTGCTTAGTTTTGTCGGTGATTGTGAGGTTGACTTGGACTATCGAATGGACCCGGAAACAAAGCTAAATGCGGCAGCCAAGCATAAGCAGAAGGACTTGCGGAAACAAGACGCCCGTCACTACTACGAACAGCAGGCCATATCCAGCATGATGCGATCCCTGAGCGTAAGCGACTCTGCCTCCGGCCCTGAGGCCATTACCGGACCGCAGGAAAGCACTCGAAGCGAGGGCAAGAACTGGTCTCGTGTGGTGGACAAAAAGGATCAGAAGCGGAAGCTGGCCGACACTGCCCTGAAATTGAACAACACACTCAAGCTGGAAGAGCCACCGAGGCCGGAGCTAGAGGTCATTGAACGGGCGCCCATTAAGGAGCAAACGCCACCGCCAACCTCCCCCGCAGCAGAGACCAGTACGCCGCTGAGTAAAAGCTACAATCTGGATCTCAGCTCCCTGACGCCCCAGTCGCAGAAACTGTCACAGAAGCAACGGAAACGGCTCTCCTCCGAATCGAAGAGCTGGCGCTCGCCTCTGGTGGAGCAAGAGCCCACCACTCCTGTGGCTGTTCCGAATGCCTGGGGCTTGCCACCCGCCACTCCGTCGAGTAGTTCCATTAGCGACTCCATTTCGCCAGCAACAGGCAGTGTTTCGGATCCCACCTCCTTTGCCAATATGATGCGAGGCCAAGCGGCGGCCGCCACAACCCCCGCGGAGAAGGGGCAAAGTTTCTCGAGGATCCTTGCCGACGAGCGACGCCAGCGGGAGTCCTTCGAGAGGATGCGGAACAAGTCACTGGTCCACACACAAATCGAGGAGACAGCCATTGCCGAGCTGCGTGAATTTTACAACGTCGACAATATCGATGACGAGACAATAACCATTGAACGAAAGTCCAGACCCGCAGACATCAACTTCAGCACTTGGTTGAAGCACTGA
Protein Sequence
MSTAKAQEYDCTAKCTCRQHGNCITAALTKRSIDNQNLGAFIFKTCGNFANIIDDLGRSAVHMSASVARYEILEWLLNHGAYINGLDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDEDFTTESQNDVLVWGSNKNYNLGIGNEQNTNAPQAVDFFRKSNIWIEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVSSKLNDDSIMCISVSRQHSLLLTHRSLVFACGINTDHQLGVRDAPENLTQFREVVALRDKGASDLLRVIACDQHSIAYSTKCVYVWGANQGQFGISRSTDAIMVPTLIKLPARTSIRFVEANNAATVIYTEEKIITLFYGDKTRYIKTPNYEDLKSIEVMGGHLKNSVKGSAAALKLLMLTETNVVFLWYENTQQFYRCNFSPIRLPEIKKVLYKCNQVLILSLDGCVYRGKCNQIALPASMLEEKSKPNLDIWHNNDQNRTEISREHVIRIDLQRVPNIDRATDIFCDESFSSFAVLQESHMKYFRKPPLPRREHNFKKLYHDTCESDAVHDVVFHVDGERFAAHKFIIYSRAPGLRELTRIYLDKNVYLNFENLTGKMFELILKYIYTSYWPTEDDIDCIQESLGPSNPRERSRACEMFIPHLETFQLVDLARYLESYVRDNQFPLPSARQRFNRLHRSDYPELYDVRIVCEDSTVLEAHKCMLVSRLEYFEMMFMHSWAESTTVNMEGVPAEYMEPVLDYLYSLDTEAFCKHNHSETFLYNMITFCDQYFIESLQNVCESLILDKINIRKCGEMLDFAAMYNCKLLHKGCMDFICHNLARVLCYRSIEQCNEATLKCLNDHYRKMFSNVFDYRQITPFSEAIEDELLLSFVGDCEVDLDYRMDPETKLNAAAKHKQKDLRKQDARHYYEQQAISSMMRSLSVSDSASGPEAITGPQESTRSEGKNWSRVVDKKDQKRKLADTALKLNNTLKLEEPPRPELEVIERAPIKEQTPPPTSPAAETSTPLSKSYNLDLSSLTPQSQKLSQKQRKRLSSESKSWRSPLVEQEPTTPVAVPNAWGLPPATPSSSSISDSISPATGSVSDPTSFANMMRGQAAAATTPAEKGQSFSRILADERRQRESFERMRNKSLVHTQIEETAIAELREFYNVDNIDDETITIERKSRPADINFSTWLKH