Dmal005860.1
Basic Information
- Insect
- Drosophila malerkotliana
- Gene Symbol
- ibtk
- Assembly
- GCA_018153235.1
- Location
- JAECXV010000075.1:15813340-15817320[-]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 4.8e-08 1.2e-05 25.2 0.0 4 79 555 626 552 675 0.80 2 3 5.7e-15 1.5e-12 47.5 0.8 9 104 695 793 688 798 0.86 3 3 0.033 8.6 6.4 0.5 59 109 782 830 773 831 0.86
Sequence Information
- Coding Sequence
- ATGTCAGCTGCCAGGACTAGTCAAGACTGTGACTGCACTGCCAAGTGCAGGCTACGCCAGCATGGAAACAATATTACTGCGGCGCTGACAAAGCGCTCCATTTCCAGCCAGAACCTTGCCGCTTTCGTTTATAAGACTTGTGGGAATTTCGCCAACATACTGGACGACCTGGGACGATCTGCAGTGCACATGTCCGCATCAACGGGCCGCTACGAGATCCTGGAGTGGCTGCTGAACCATGGAGCCTACATCAATGGCCAGGATTACGAATCTGGAAGTAGTCCCCTTCACCGGGCCTTGTACTACGGTTCTATAGACTGTGCTGTGCTTTTACTTCGCTATGGAGCCAGTATGGACCTGCTGGACGAGGACACTCGATGCCCTTTACAGGCCATCTGCCGGAAATGTGACGTTGATGACTTTGCCATAGATTCACAAAACGATATTTTGGTCTGGGGCTCCAACAAAAACTACAACCTGGGCGTTGGCAGCGAGCAAAACACCAATGCTCCTCAGAGTGTTGACTTCTTTCGCAAATCCAACATTTGGATTGAACAGGTGGCCCTAGGTGCCTACCACAGTCTGTTCCTGGATAAGAAAGGTCACCTGTATGCCGTAGGTCATGGCAAAGGCGGTCGACTGGGCATCGGAGGGGAGAACACCCTGCCGGCACCTAAGCGTGTTAAAGTCTCCTCCAAGCTGGGCGATGACTCCATCCGTTGCATCAGCGTCTCCCGCCAGCACTCACTGGTGCTCACGCACCGATCTCTAGTTTTCGCCTGCGGCTTAAATAGCGACTGTCAGCTCGGGGTGCGTGACGCACCTGAGCACCTTGCCCAGTTCAAGGAAGTGGTCGCCTTGCGTGACAAAGGTGCTAGCGATTTGGTGCGTGTCATCGCCTGCGACCAGCATTCAATAGCCTACGGCAGCAGGTGTGTCTACGTTTGGGGGGCCAACCAGGGCCAGTTTGGCATCAGTGCCAATACACCTAGCATCGTAGTGCCCACTCAGATCAAACTGCCAGCGAAGACGACCATCCGTTTTGTAGAAGCCAACAACGCAGCCACGGTAATTTACAGTGAGGAAAAAATGATATACCTATACTACGCCGAAAAGACAAGGGCGATTAAGACGCCCAACTATGAAGACCTCAAAAGCATTTCCGTGATGGGTGGCAATATAAAGAACTCAGCAAAGGGTTCTGCGGCAGCTTTAAAGCTCCTGATGCTTACCGAAACCAACGTGGTGTATCTCTGGTACGAGAACACCCAGCAATTTTACAGATGCAATTTCCTTCCTATAAGACTGCCACAAATAAAAAAAATCCTCTACAAGTGCAATCAGGTTATGGTTCTGTCTGAAGATGGCTGTGTTTATCGCGGGAAGTGCAATCAGATTGCTCTTCCCGCTTCGGAACTCCAAGAAAAGTCTCGGCCGAACTTGGACATTTGGCAGAACAACGATCAGAACAAGACGGAAATATCCCGGGAGCATGTAATCCGCATTGAACTGCAACGGGTTCCCAACATCGATCGTGCCATTGACATATCCTGCGACGAAGGCTTTTCCTCCTTCGCTGTGCTTCAAGAGTCACAGGGTAAATACTTTCGCAAACCCACACTGCCACGCAAGGAGCATAGCTTTAAGAAGCTCCTTCACGACACCAGCGACTGTGATGCTGTCCACGACGTAGTGTTTCATGTGGATGGCGAAAAATTTCCCGCCCACAAGTTTATCATTTACAGTCGAGCTCCTGGACTCAGAGAGCTTGTAAGGATGTATCTGGATAAAGACATTTACTTAAATTTCGAGAACCTAACTGGAAGGATGTTCGAACTGGTTTTGAAGCATATCTACACGAACTATTGGCCCACGGAAGATGATATCGATTGCATACAGCAGAGTTTAGGACCAGCCAATCCCCAAAACCGAAGCCGGACTTGTCAAATGTTCCTGCCGCATCTTGAAAAGTTCCAACTACGAGAGCTGGCCAAGTTTGTGAAGAGCTATGTTCAGGACCATCAATTTCCGCTTCCGAATGCCCGCCAGCGTCTGCCTCGGCTCCACCGCTCCGATTACCCGGAGCTTTATGATGTGAAGATAAAATGTGAGGACGGAAAAGTCCTACAGGCACACAAATGCATGTTGGTGGCCCGCCTGGAGTACTTTGAGATGATGTTCATGCATTCGTGGGCGGAGCGTACAAGCGTCACCATGGAGGGTGTACCTGCGGAGTATATGGAACCAGTACTGGACTATCTCTATAGCCTAGAGGCAGAAGCCTTCTGCAAGCAGGGATATCTGGAGACGTTTCTCTACAATATGATCACCATATGCGACCAATACTTTATTGAATCGCTGCAGAATCTGTGCGAGCTGCTTATCCTCGACAAGATTAGTATCCGCAAGTGTGGCGAGATGCTGGAATTCGCCACGATGTACAACTGCAAGTTGTTACTAAAGGGCTGCATGGACTTTATTTGCCAAAATCTAGCCAGAGTTCTCTGTTACCGCAGCATCGAGCAGTGTGATGGAGAAACTCTGAAGGGCCTTAATGATCACTATCGCAGTATGTTTAGAAGGGTGTTCGACTACCGTCAGATCACACCGTTTTCAGAGGCTATAGAAGACGAACTACTTCTGAGTTTTATCGATGGATTAGAGGTGGATCTGGAGTACCGAATGGATGCGGAATCGAAGGCGAAGCAGGCGGCTAAAACTAAGCAGAAGGATCTTCGCAAGCTAAATGCACGGCATCAATACGAACAGCGAGCTATATCCAGCATGATGAGGTCTATAAGCATAAGTGAATCTAATCCAGCTCCAGAGGTGGCCACCTCTCCGCAGGAAAGTGCTCGTAGCGACACCAAAAACTGGTCTCGAGTCATTGATAAAAAAGAACAGAAGCGCAAGCAAGCAGAAACCGCCTTAAAGGTCAACAAAACCCTTACCCACGAGATGCCGCCTGAACCTGCAATGGTGCCCATTGAAAGAACGCCGGTGAAGGAGCAAACACCTCCGCCTCATTCCCCCGAAACGGAATCTTCGACTCCACTAAACAAGAGCTATAACTTGGACTTTAGCTCGCTGACACCCCAGTCCCAGAAGCTATCGCAGAAGCAACGGAAGCGTCTCTCGTCCGAGTCAAAAAGCTGGCGAGTCAACAGTTCCGCTTTGTTGGAGTCACCCACCACTCCTGTGTCAGTGCCCAATGCCTGGGGTGTGACCACTACACCTTCCAGTTCTTTCAACGATTCTTACAATTCCCCGGCTACTGGAAGCAGCTCGGATCCCACTTCGTTTGCAAACATGATGAGGAGTCAGGCGGCTTCTGCTTCTGCCACTTCAAAGGATCAAACTCAAAACTTCTCGAAGATCCTAGCGGATGAGCGAAGACAGCGGGAATCCTACGAGCGCATGCGCAACAAGTCGTTGGTGCACACGCAGATCGAGGAGACGGCCATCGCCGAGCTAAAGGAGTTCTACAATGTAGACAATATCGACGACGAGAAGATCACCATTGCTCGCAAGTCCAGGCCCAGTGACATAAACTTCAGCACCTGGATTAGGCAGTGA
- Protein Sequence
- MSAARTSQDCDCTAKCRLRQHGNNITAALTKRSISSQNLAAFVYKTCGNFANILDDLGRSAVHMSASTGRYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASMDLLDEDTRCPLQAICRKCDVDDFAIDSQNDILVWGSNKNYNLGVGSEQNTNAPQSVDFFRKSNIWIEQVALGAYHSLFLDKKGHLYAVGHGKGGRLGIGGENTLPAPKRVKVSSKLGDDSIRCISVSRQHSLVLTHRSLVFACGLNSDCQLGVRDAPEHLAQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFGISANTPSIVVPTQIKLPAKTTIRFVEANNAATVIYSEEKMIYLYYAEKTRAIKTPNYEDLKSISVMGGNIKNSAKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFLPIRLPQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPASELQEKSRPNLDIWQNNDQNKTEISREHVIRIELQRVPNIDRAIDISCDEGFSSFAVLQESQGKYFRKPTLPRKEHSFKKLLHDTSDCDAVHDVVFHVDGEKFPAHKFIIYSRAPGLRELVRMYLDKDIYLNFENLTGRMFELVLKHIYTNYWPTEDDIDCIQQSLGPANPQNRSRTCQMFLPHLEKFQLRELAKFVKSYVQDHQFPLPNARQRLPRLHRSDYPELYDVKIKCEDGKVLQAHKCMLVARLEYFEMMFMHSWAERTSVTMEGVPAEYMEPVLDYLYSLEAEAFCKQGYLETFLYNMITICDQYFIESLQNLCELLILDKISIRKCGEMLEFATMYNCKLLLKGCMDFICQNLARVLCYRSIEQCDGETLKGLNDHYRSMFRRVFDYRQITPFSEAIEDELLLSFIDGLEVDLEYRMDAESKAKQAAKTKQKDLRKLNARHQYEQRAISSMMRSISISESNPAPEVATSPQESARSDTKNWSRVIDKKEQKRKQAETALKVNKTLTHEMPPEPAMVPIERTPVKEQTPPPHSPETESSTPLNKSYNLDFSSLTPQSQKLSQKQRKRLSSESKSWRVNSSALLESPTTPVSVPNAWGVTTTPSSSFNDSYNSPATGSSSDPTSFANMMRSQAASASATSKDQTQNFSKILADERRQRESYERMRNKSLVHTQIEETAIAELKEFYNVDNIDDEKITIARKSRPSDINFSTWIRQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00517826;
- 90% Identity
- iTF_00476017;
- 80% Identity
- -