Daff001937.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila affinis
Gene Symbol
ibtk
Assembly
GCA_037356375.1
Location
CM074799.1:14221293-14226019[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.2e-08 4.5e-06 27.1 0.1 6 78 555 623 550 634 0.86
2 3 2.9e-14 6e-12 46.0 1.7 8 107 690 794 683 797 0.85
3 3 0.32 66 4.0 0.2 62 109 783 828 778 829 0.84

Sequence Information

Coding Sequence
ATGTCAACTGCCAAGGCCCAGGAATATGACTGCACTGCGAAGTGTACATGTCGCCAGCATGGAAACTGCATCACAGCGGCACTCACAAAGCGCTCAATCGACAATCAAAATCTGGGAGCGTTTATCTTCAAGACTTGCGGAAATTTCGCCAACATCATAGATGACCTGGGCCGCTCTGCAGTGCACATGGCAGCTTCGGTGGCGCGATATGAGATTCTAGAGTGGCTATTGAATCACGGGGCTTACATTAACGGACTCGACTACGAGTCTGGCAGTAGTCCCTTGCACAGGGCCCTGTACTACGGCTCCATAGACTGTGCTGTGCTTCTGCTTCGATATGGGGCAAGCCTGGAACTGTTGGACGAAGACACACGGTGTCCGCTGCAAGCCATCTGTCGCAAGTGCGACGAAGATTTCACCACGGAGTCACAGAACGATGTTCTCGTCTGGGGCTCTAATAAGAACTATAACCTCGGCATTGGCAACGAGCAGAACACGAATGCTCCTCAAGCGGTGGATTTCTTTCGAAAGTCCAACATCTGGATAGAGCAAGTAGCATTGGGGGCCTATCACAGTCTCTTTTGCGACAAGAAGGGTCACCTCTATGCCGTCGGCCATGGTAAAGGCGGACGCTTGGGCATTGGTGTGGAGAACAGTTTGCCAGCTCCAAAGCGTGTGAAGGTCTCTTCAAAGCTGAACGATGATTCCATAATGTGCATAAGTGTCTCCCGACAGCACTCTCTGCTGCTCACGCATCGTTCGTTGGTTTTTGCCTGCGGCATCAACACCGACCATCAGCTGGGGGTGCGTGATGCGCCCGAGAATCTGACGCAGTTCAGGGAGGTTGTCGCATTGCGTGACAAGGGGGCCAGCGATCTGCTGCGTGTGATCGCCTGCGATCAGCACTCCATTGCCTACAGCACCAAGTGTGTGTACGTCTGGGGTGCCAATCAGGGGCAATTTGGCATAAGTCGCAACACAGACGCTATCATGGTGCCCACATTGATAAAACTACCTGCGCGCACATTAATCCGTTTTGTGGAAGCCAACAATGCAGCCACGGTAATTTACACAGAGGAGAAGATGATTACCTTATTTTATGGTGACAAAACTAGATACATTAAGACTCCAAACTACGAAGATCTCAAAAGTATTGCGGTGATGGGTGGCCATTTAAAGAACTCCGCGAAAGGATCTGCAGCAGCCCTAAAGCTACTGATGCTCACTGAGACGAATGTGGTGTTCCTGTGGTATGAGAACACACAGCAATTCTACAGGTGCAATTTTTCGCCAATACGTCTGCCTGAGATTAAAACGGTTTTGTACAAGTGCAATCAAGTCCTGATATTGTCCTTGGATGGTTGCGTCTATCGCGGCAAGTGCAATCAGCTAGCTGTGCCAGCCAGCATGCTAGAAGAGAAATCCAAGCCCAATCTGGATATATGGCACAACAACGATCAGAATCGCACGGAGATTTCAAGAGAGCATGTGATCCGCATCGATCTGCAGCGTGTGCCCAACATTGATCGTGCCACCGATATCTTTTGCGACGAGAGCTTCTCTTCGTTCGCCGTGCTGCAGGAGTCGCACATGAAGTACTTCCGTAAGCCCCCACTGCCACGCAGGGAGCACAATTTCAAGAAGCTCTACCATGACACCTGCGAATCGGATGCCGTGCACGATGTTGTCTTCCATGTGGATGGGGAGCGCTTTGCGGCTCACAAGTTTATTATCTATAGTCGGGCACCAGGCCTCAGGGAGCTCACTCACATTTACTTGGACAAGAATGTCTATTTGAACTTTGAAAATCTAACAGGAAAGATGTTTGAGTTGATCCTAAAGTATATCTACACCAGTTACTGGCCAACAGAGGATGATATCGACTGCATCCAGGAAAGTTTGGGGCCCTCCAACCCTCGAGAGCGCAGTCGAGCCTGCGAAATGTTTATCCCGCACTTGGAGACGTTTCAGCTGGTCGATCTAGCCAGATACTTGCAGAGTTACGTACAAGATAATCAATTTCCTCTGCCTAGTGTCCGGCAGCGTTTCAATCGGCTGCATCGCTCAGACTATCCAGAGCTCTACGATGTACGAATAGTCTGCGAGGACTCGAAAGTTCTGGAAGCCCATAAATGCATGCTGGTGTCGCGCTTAGAGTACTTTGAAATGATGTTTATGCACACGTGGGCCGAGAGCACCACGGTGAACATGCAGGGAGTGCCCGCTGAGTATATGGAGCCAGTTCTGGACTATCTCTACAGCCTGGATACGGAGGCATTCTGCAAACAGAACCATTCGGAAACCTTTCTCTACAACATGATCACGTTCTGCGATCAGTACTTCATTGAATCGCTGCAGAATGTTTGTGAATCACTCATTCTAGACAAGATTAATATACGCAAGTGCGGCGAGATGTTGGACTTTGCCGCGATGTACAACTGCAAGCTGCTGCAGAAGGGATGCATGGACTTCATCTGCCACAACCTGGCTAGAGTCCTCTGCTACCGCAGCATCGAACAGTGCGACGAGGCGACTCTCAAATGTCTCAACGAGCATTATCGTAAGATGTTCTCCAATGTCTTCGACTACCGCCAGATCACGCCATTTTCAGAGGCGATTGAGGATGAGCTGCTGCTTAGTTTTGTCGATAAATGTGAGGTGGACTTGGAATATCGAATGGACCCGgAAACAAAGCTAAATGCGGCCGCCAAGCATAAGCAAAAGGACTTGCGGAAGCAAGACGCCCGTCACTACTACGAACAGCAGGCCATATCCAGCATGATGCGAAGTCTAAGCGTTAgcgactctgcctctgcccctgagACTATTACCGAACCGCAGGAAAGCACTCGAAGTGAGGCCAAGAACTGGTCTCGTGTGGTGGACAAAAAGGAACAGAAGCGAAAGCTAGCCGACACTGCCCTGAAAGTAAACAACACACTCAAGCTTGAAGAGCCACCGAGGTCGGAGCTAGAGGTCATTGAAAGAACGCCCATTAAGGAGCAAACGCCACCGCCAACCTCCCCAGCAGAGACCAGTACGCCGCTGAGTAAAAGCTATAATCTGGATCTCAGCTCCTTGACCCCCCAGTCGCAGAAACTGTCACAGAAGCAACGGAAACGGCTTTCCTCCGAATCGAAGAGCTGGCGTTCGCCCTTGGTAGAACAAGAGCCCACCACTCCTGTGGCTGTGCCGAATGCCTGGGGCTTGCCACCCGCCACAGCTTCTAGTAGTTCCTATAGCGAATCGCCAGCAACAGGCAGTGTTTCGGATCCCACATCCTTTGCCAATATGATGAGAGGACAAGCGGCGTCCGCAAAAACCCCCACGGAGAAGGGACACAGTTTCTCGAGGATCCTTGCCGATGAGCGACGCCAGCGGGAGTCCTTCGACAGGATGCGTAACAAGTCTCTGGTCCACACACAAATCGAGGAGACAGCCATTGCCGAGCTGCGTGAGTTCTACAACGTTGACAATATCGATGACGAGACAATAACGATTGAACGAAAGTCCAGACCCGCAGACATCAACTTCAGCACTTGGTTGAAACACTAA
Protein Sequence
MSTAKAQEYDCTAKCTCRQHGNCITAALTKRSIDNQNLGAFIFKTCGNFANIIDDLGRSAVHMAASVARYEILEWLLNHGAYINGLDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDEDFTTESQNDVLVWGSNKNYNLGIGNEQNTNAPQAVDFFRKSNIWIEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVSSKLNDDSIMCISVSRQHSLLLTHRSLVFACGINTDHQLGVRDAPENLTQFREVVALRDKGASDLLRVIACDQHSIAYSTKCVYVWGANQGQFGISRNTDAIMVPTLIKLPARTLIRFVEANNAATVIYTEEKMITLFYGDKTRYIKTPNYEDLKSIAVMGGHLKNSAKGSAAALKLLMLTETNVVFLWYENTQQFYRCNFSPIRLPEIKTVLYKCNQVLILSLDGCVYRGKCNQLAVPASMLEEKSKPNLDIWHNNDQNRTEISREHVIRIDLQRVPNIDRATDIFCDESFSSFAVLQESHMKYFRKPPLPRREHNFKKLYHDTCESDAVHDVVFHVDGERFAAHKFIIYSRAPGLRELTHIYLDKNVYLNFENLTGKMFELILKYIYTSYWPTEDDIDCIQESLGPSNPRERSRACEMFIPHLETFQLVDLARYLQSYVQDNQFPLPSVRQRFNRLHRSDYPELYDVRIVCEDSKVLEAHKCMLVSRLEYFEMMFMHTWAESTTVNMQGVPAEYMEPVLDYLYSLDTEAFCKQNHSETFLYNMITFCDQYFIESLQNVCESLILDKINIRKCGEMLDFAAMYNCKLLQKGCMDFICHNLARVLCYRSIEQCDEATLKCLNEHYRKMFSNVFDYRQITPFSEAIEDELLLSFVDKCEVDLEYRMDPETKLNAAAKHKQKDLRKQDARHYYEQQAISSMMRSLSVSDSASAPETITEPQESTRSEAKNWSRVVDKKEQKRKLADTALKVNNTLKLEEPPRSELEVIERTPIKEQTPPPTSPAETSTPLSKSYNLDLSSLTPQSQKLSQKQRKRLSSESKSWRSPLVEQEPTTPVAVPNAWGLPPATASSSSYSESPATGSVSDPTSFANMMRGQAASAKTPTEKGHSFSRILADERRQRESFDRMRNKSLVHTQIEETAIAELREFYNVDNIDDETITIERKSRPADINFSTWLKH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00517826;
90% Identity
iTF_00517826; iTF_00487394; iTF_00474605; iTF_00611447; iTF_00564024; iTF_00514991; iTF_00601155; iTF_00473878; iTF_00484530; iTF_00480950; iTF_00603451; iTF_00580832; iTF_00536126; iTF_00574911;
80% Identity
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