Dtru002506.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila truncata
Gene Symbol
ibtk
Assembly
GCA_008042515.1
Location
VNJQ01006215.1:373170-377139[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.4e-07 4.4e-05 23.7 0.0 4 79 554 625 551 654 0.84
2 3 7.1e-15 2.3e-12 47.1 0.7 9 105 694 793 685 798 0.87
3 3 0.086 28 5.0 0.5 61 109 783 829 774 830 0.83

Sequence Information

Coding Sequence
ATGTCAGCTGCCAGGAGCCAGGAATATGATTGTACCACGAAGTGCAGACACCGCCAGCATGGCAACACCATCACAGCGGCGCTAACGAAGCGTTCAATCGACAACCGGAAGCTGGcggcttttattttcaagactTGCGGAAATTTCGCCAATATTCTCGATGACCTGGGGCGCTCAGCAGTTCACATGGCCGCCTCGACGGGGCGGTACGAGATCCTGGAGTGGCTTCTCAATCATGGCGCCTACATCAACGGCCAGGACTATGAATCTGGCAGCAGTCCTCTGCATCGGGCCCTGTACTACGGCTCCCTAGACTGtgccgtgctgctgctgcgatatGGCGCCAGTCTGGAACTCTTAGACGAGGACACACGGTGTCCCCTGCAGGCGATTTGCCGGAAATGCGACTACTACGATGGCACAGATTCGCAAAACGATGTCTTGGTCTGGGGCTCTAACAAAAACTACAATCTCGGGATTGGCAGCGAGCAAAACACCAATGCGCCGCAGGTTGTGGATTTCTTTCGAAAGTCCAGCATTTACTTGGAACAGGTTGCCCTGGGCGCCTATCACAGTCTCTTTTGCGACAAGAAGGGGCACCTGTACGCCGTGGGACACGGCAAGGGTGGTCGCCTCGGCATCGGAGTGGAGAACAGCTTGCCAGCACCCAAGCGCGTGAAGGTCTCCTCTAAGCTGGGCGACGATTCCATTCTCTGCATCAGCGTCTCCCGCCAACACTCGCTGGTGCTCACGCACCGCTCGCTGGTTTTCGCCTGCGGCCTCAATAGCGACCATCAGCTGGGCGTGCGTGACGCACCCGAGCACCTCGCCCAGTTTAAAGAAGTGGTCGCCTTGCGTGACAAGGGTGCCAGCGACCTCATGCGCGTGATTGCCTGCGATCAACACTCCATCGCCTACGGCAGCAGGTGTGTCTACGTCTGGGGGGCCAATCAGGGTCAGTTTGGCATCAGTGCTAACACGCCGAGCATTATGGTTCCCACAATGATCAAGCTGCCAGCTAGGACCACCATTCGCTTTGTAGAGGCCAACAATGCAGCCACGGTAATTTACAGCGAAGAAAAGATGATAACGCTGTTTTACGCCGATAAGACTAGATACATTAAGACGCCCAACTACGAGGATCTCAAAAGCATATCGGTGATGGGTGGCCACTTGAAGAACTCTGCCAAGGGTTCGGCCGCAGCTCTGAAGCTACTGATGCTTACCGAAACCAATGTGGTGTATCTCTGGTACGAGAACACACAACAATTTTATAGATGCAATTTCTCGCCCATCCGACTCCCAGAGATTAAGAAAATCCTCTACAAATGCAACCAGGTAATGGTACTTTCGGACGATGGCTGTGTTTATCGCGGCAAGTGCAATCAGATCGCTTTGCCTGCCTCCGCGCTTCAGGAGGACAGGTCCCGGCCCAACCTGGACATCTGGCAAAACAAtgatcaaaataaaactgagaTCTCCCGCGAGCATGTTATACGCATTGAACTGCAGCGCGTGCCTAACATCGACCGAGCCATTGATATATATTGCGATGAGGGTTTCTCTTCGTTTGCGATACTACAAGAGTCGCATAGCAAGTATTTTAAGAAGCCGCAACTGCCACGCAAGGAGCACAGCTTTAAGAAGCTGCTGCATGACACCAGCGACTGTGACGCCGTCCACGATGTGGTCTTTCATGTGGACGGCGAGAAGTTTCCCGCCCACAAGTTCATAATTTACAGCAGGGCTCCGGGACTCAGAGAGCTTATACGCTTGTATCTAGACAAGGATATTTACCTCAACTTTGAGCATTTAACAGGAAAGATGTTTGAACTGGTCCTCAAGCATATCTACTCGAGCTACTGGCCCACCGAGGATGATATCGACTGCATTCAGCAGAGTTTGGGCCCAGCGAATCCCCAGGAGCGGAAACGCACCTGCGAGATGTTCCTACCGCACTTGGAAAAGTTCCAACTGGTCGATTTGGCCAAGTATGTTCAGTGCTATGTGCGGGACCATCAATTCCCACTGCCCAATGCCCGTCAGCGATTCAGTCGCTTGCATCGTTCCGATTTCCCCGAGCTCTACGACGTGCGGATTGTGTGCGAAGACGGCAAGGTACTAGAGGCTCACAAATGCATGCTGGTTGCCCGGCTGGAGTACTTTGAGATGATGTTCATGCACATGTGGGCGGAGCGCTCTTCGGTTACCATGGAGGGAGTGCCTGCGGAGTATATGGAGCCGGTGCTGGACTATCTCTACTGCCTGGAAACGGAGGCCTTTTGCAAGCAGGGTTACCTGGAGACGTTCCTctacaacatgatcaccatcTGCGATCAGTATTTTATTGAGTCACTGCAGAACGTGTGCGAACTGCTCATTCTGGATAAGATTAGCATACGGAAGTGCGGCGAGATGCTCGAATTCGCAGCCATGTACAACTGCAAGCTGCTGCAAAAAGGATGCATGGACTTTATATGTCAGAACCTGGCCAGGGTGCTCTGCTATCGCAGCATAGAGCAGTGCGACGGtgaaactttaaatgcccTGAACGAGCACTACCGAAAGATGTTCAGCAAGGTCTTCGACTACCGACAAATCACACCTTTCTCGGAGGCCATTGAAGACGAGCTGCTTCTCAGTTTCGTGGACGATTGCGAGGTGGATCTGGAGTATCGAATGGATGCGGAATCAAAGCTGAAGCAGGCTGCTAAACATAAGCAGAAGGACTTGCGCAAGCAAGATGCCCGCCATCATTACGAACAACAGGCCATATCCAGCATGATGAGATCCATAAGTATCAGTGAGGCTGCCGAGGTGCCGGCATCTCCAAAAGAAAATGCTTACAGTGAGGCTAAAAACTGGTCACGAGTGGTGGATAAGAAGGAGCAGAAGCGAAAGCAGGCTGAGACGGCATTAAAAGTCAACAACACGCTCAAGCAGGAGGAGCCACCGACGCCTGCACTGGTGCCCATTGAGAAGACGCCCGTCAAGGAGCAAACACCACCTCCTTTATCGCCTGAAACGGAGCCCGGCACTAGCACGCCTCTGAACAAGAGCTACAATCTTGATCTAAGCTCCCTTACGCCCCAGTCGCAGAAGTTGTCCCAGAAGCAGCGAAAGCGTCTCTCCTCCGAATCCAAAAGCTGGCGTGCGAATAGTACACCTCTAGTGGAGCAGTCCTCGACTCCGGTGGCCATTCCGAATGCTTGGGGTGTGACCACCACGCCATCAAGTTCGTTTAACGATGCCTACAGTTCCCCAGCCACTGGTAGCAGCACGGATCCCACCTCATTCGCCAACATGATGAGGGGTCAGCAAGCTGCTGCCACAACGCCCACCGAGACGAGCCAGAGTTTCTCACGCATCCTGGCTGATGAGCGACGACAGCGAGAGTCATACGAACGGATGCGTAACAAATCTCTGGTTCATACTCAGATTGAGGAGACGGCCATAGCCGAGCTAAGGGAGTTCTACAACGTGGACAACATTGACGACGAGACCATTACCATTGCCCGCGTGTCCAGGCCCAGTGACATCAACTTTAGCACTTGGCTGAAGCAGTGA
Protein Sequence
MSAARSQEYDCTTKCRHRQHGNTITAALTKRSIDNRKLAAFIFKTCGNFANILDDLGRSAVHMAASTGRYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSLDCAVLLLRYGASLELLDEDTRCPLQAICRKCDYYDGTDSQNDVLVWGSNKNYNLGIGSEQNTNAPQVVDFFRKSSIYLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVSSKLGDDSILCISVSRQHSLVLTHRSLVFACGLNSDHQLGVRDAPEHLAQFKEVVALRDKGASDLMRVIACDQHSIAYGSRCVYVWGANQGQFGISANTPSIMVPTMIKLPARTTIRFVEANNAATVIYSEEKMITLFYADKTRYIKTPNYEDLKSISVMGGHLKNSAKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLPEIKKILYKCNQVMVLSDDGCVYRGKCNQIALPASALQEDRSRPNLDIWQNNDQNKTEISREHVIRIELQRVPNIDRAIDIYCDEGFSSFAILQESHSKYFKKPQLPRKEHSFKKLLHDTSDCDAVHDVVFHVDGEKFPAHKFIIYSRAPGLRELIRLYLDKDIYLNFEHLTGKMFELVLKHIYSSYWPTEDDIDCIQQSLGPANPQERKRTCEMFLPHLEKFQLVDLAKYVQCYVRDHQFPLPNARQRFSRLHRSDFPELYDVRIVCEDGKVLEAHKCMLVARLEYFEMMFMHMWAERSSVTMEGVPAEYMEPVLDYLYCLETEAFCKQGYLETFLYNMITICDQYFIESLQNVCELLILDKISIRKCGEMLEFAAMYNCKLLQKGCMDFICQNLARVLCYRSIEQCDGETLNALNEHYRKMFSKVFDYRQITPFSEAIEDELLLSFVDDCEVDLEYRMDAESKLKQAAKHKQKDLRKQDARHHYEQQAISSMMRSISISEAAEVPASPKENAYSEAKNWSRVVDKKEQKRKQAETALKVNNTLKQEEPPTPALVPIEKTPVKEQTPPPLSPETEPGTSTPLNKSYNLDLSSLTPQSQKLSQKQRKRLSSESKSWRANSTPLVEQSSTPVAIPNAWGVTTTPSSSFNDAYSSPATGSSTDPTSFANMMRGQQAAATTPTETSQSFSRILADERRQRESYERMRNKSLVHTQIEETAIAELREFYNVDNIDDETITIARVSRPSDINFSTWLKQ