Dlut000682.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila lutescens
Gene Symbol
ibtk
Assembly
GCA_037075285.1
Location
JBAMCF010000007.1:4357346-4361320[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.1e-08 2.8e-06 27.7 0.1 4 79 554 625 551 665 0.85
2 3 5.7e-15 1.5e-12 47.9 0.9 9 107 694 795 685 798 0.88
3 3 0.47 1.2e+02 3.1 0.1 82 109 802 829 796 830 0.87

Sequence Information

Coding Sequence
ATGTCAGCCGCCAGGAGCCAGGAATACGATTGCACCACGAAGTGCAGACACCGCCGGCATGGAAACGCCATCACCGCCGCGCTGACGAAGCGCTCCATTGACCACCAGAAGCTGGCggcttttattttcaagacGTGCGGAAATTTCGCCAATATTCTAGACGACCTGggTCGATCGGCGGTGCACATGTCCGCCTCCACGGCGCGCTATGAGATTCTGGAGTGGCTACTCAACCACGGGGCCTACATCAATGGCCAGGACTACGAGTCGGGCAGTAGTCCATTGCACAGAGCCCTTTACTATGGCTCCATAGACTGCGCCGTACTGCTGCTACGCTACGGAGCCAGTTTGGAGCTCCTGGACGAGGACACCAGGTGTCCCCTGCAAGCCATCTGCCGGAAGTGCGATGATGAAGACTTCGCCACGGATTCCCAAAACGATGTCCTGGTTTGGGGCTCCAACAAGAACTACAACCTGGGCATTGGCAACGAGCAGAACACCAATGCCCCGCAAGCGGTGGACTTCTTCCGCAAGTCCAACCTTTGGCTGGAACAGGTGGCCCTGGGCGCCTACCACAGCCTTTTCTGCGACAAGAAGGGTCATCTGTATGCCGTGGGTCATGGCAAGGGCGGTCGCCTGGGCATCGGACAGGAAAACAGCCTGCCTGCTCCCAAGAGGGTGAAGGTATCGTCCAAACTGGGTGACGACTCCATACGGCACATCAGTGTGTCCCGCCAGCACTCCCTGGTGCTCACGAATCGCTCGCTGGTTTTCGCCTGCGGCATTAACACAGACCATCAGCTGGGAGTGCGTGATGCCAACGAGCATCTCACCCAGTTCAAGGAAGTGGTCGCCTTGCGTGACAAAGGTGCCAGCGATCTGGTGCGCGTGATCGCCTGCGATCAGCACTCGATCGCCTACGGCAGCAGGTGTGTTTACGTCTGGGGGGCCAATCAGGGCCAGTTTGGCATCAGTGCCAACACGCCGAGCATTATGGTGCCCACACTGATTAAGCTTCCTGCCAAGACTACAATCCGTTTTGTGGAGGCCAACAACGCAGCCACGGTAATTTACAGCGAGGAGAAGATGATTACTCTTTACTATGCAGACAAAACAAGATATATTAAGACGCCCAACTACGAAGATCTCAAGAGCATATCGGTGATGGGTGGCAACCTAAAGAACTCCACCAAAGGCTCTGCGGCAGCTCTGAAGCTATTAATGCTCACCGAAACGAATGTGGTGTACTTATGGTACGAGAACACTCAGCAATTTTACAGATGTAATTTCTCACCCATACGCCTGCCACAAATCAAGAAAATCCTGTACAAGTGCAATCAAGTGATGGTGCTCTCCGGCGATGGCTGCGTTTATCGTGGGAAGTGCAATCAGATCGCCCTGCCAGCTTCAGGACTGCACGAAAAGACCCGCGGCAACCTGGACAACTGGCAGGACAACGATCAGAACAAAACGGAAATCTCCCGGGAGCATGTGATCCGCATCGAGCTTCAGCGAGTTCCGAACATCGACCGAGCAAACGACATATTTTGCGATGAAGGTTTCTCCTCCTTTGCCGTTCTGCAGGAGTCGCATACGAAATACTTCCGAAAGCCCACACTGCCACGAAGGGAGCACAGTTTCAAGAAACTACTGCACGATACGAGCGACTGTGATGCTGTCCACGATGTTGTGTTCCATGTGGATGGAGAGAAGTTCGCGGCCCACAAGTTCATCATTTTCAGTCGGGCTCCAGGTCTTAGGGAGCTCATACGCTGTTATCTAGACAAGGATATCTATCTCAATTTAGAGCATTTAACGGGGAAGATGTTTGAATTGATTTTGAAGTACATTTACACGTGCTACTGGCCAACAGAAGATGATATCGACTGTATCCAGCAGAGTCTGGGGCCCGCCAATCCTCAACATCGAACGCGGACCTGCGAGATGTTCCTGCCGCATCTGGAAAAGTTTCAACTAGTCGAACTGGCCAAGTACGTGCAGAGCTACGTGCGTGACCATCAATTCCCACTGCCTAATGCCCGTCAGCGTTTTAGTCGCTTACATCGCTCTGATTACCCAGAACTTTACGACGTAAGGATTGTGTGCGAAGACGGAATAGTACTGGAGGCTCATAAGTGCATGTTGGTGGCACGGTTAGAGTACTTTGAGATGATGTTCATGCACTCGTGGTCGGAACGTTCTTCTGTCACCATGGAAGGAGTTACCTCGGAGTATATGGAGCCGGTTCTGGACTACCTGTACAGCCTGGAAACCGAGACCTTCTGCAAGCAGGGCTATCTGGAGACCTTCCTGTACAATATGATCACCATATGCGACCAGTACTTCATTGAGTCCTTGCAGAACGTCTGCGAGTCGCTTATCCTGGACAAGATCAGCATACGAAAGTGCGGAGAGATGCTCGAGTTTGCCGCCATGTACAACTGCAAACTGCTGCAGAAGGGCTGCATGGACTTCATTTGCCAAAACCTGTCAAGAGTGCTTTGCTATCGCAGTATTGAGCAGTGCGACGGAGAGACGCTAAAATGCCTGAATGAGCACTATCGAAACATGTTTAAAAGGGTGTTCGACTACCGGCAAATCACTCCCTTCTCAGAGGCTATAGAAGATGAGCTATTGCTCAGTTTTGTTGACGGTTGTGAGGTGGACCTGGATTACAGAATGGATGCTGAATCACAGCTCAAGCAGGCGGCTAAGCATAAGCAGAAAGATTTGCGGAAGCAGGGAGCTCGACACCAGTATGAACAGCAGGCCATATCCAGTATGATGAGATCTCTGAGCGTCAGCGAATCTGCTCCAGGGTCAGAGGTCCCTTCATCTCCCCAGGAAAGTGCTCGCAGCGAGGTGAAAAACTGGTCTCGAGTGGTGGACAAGAAGGATCAGAAGCGGAAACAGGCTGAAACTGCTTtcaaagtaaacaatacactGAAGCAGGAAGAGCCACCGACTCCTGAACTGATTCCCATTGAAAGGAAGCCCCAGAAGGAGCAGACACCTCCGCCAATCTCCTCCGAAACGGAACCCACCACACCGCTGACCAAGAGTTACAACCTGGACTTTAGCTCCCTGACGCCCCAGTCGCAGAAACTTTCGCAAAAGCAGAGGAAGCGTCTCTCCTCCGAATCGAAGAATTGGCGGGCCAATAACCCACCCCTGGTGGAACAATCCACTCCAGTGGCCGTGCCCAATGCCTGGGGAGTAACCGCCACTCCATCGAGTTCGTTCAATGACTCATTCACTTCTCCGACCACTGGCGGCAGTTCGGATCCGACTTCGTTTGCCAATATGATGAGGGGACAGGCAGCTTCCTCCACCACACCCACTGAGCACGGGCAGAGCTTCTCGCGCATTCTGGCCGATGAGAGAAGACAGAGGGAATCCTACGAGCGCATGAGAAACAAATCTTTGGTTCACACACAGATCGAGGAGACTGCCATCGCCGAGCTGAGGGAGTTCTACAACGTGGACAACATTGATGACGAGACTATAACTATTGCCCGTATGTCCAGGCCCAGTGACATCAACTTTAGCACCTGGCTGAGGCAGTAA
Protein Sequence
MSAARSQEYDCTTKCRHRRHGNAITAALTKRSIDHQKLAAFIFKTCGNFANILDDLGRSAVHMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDDEDFATDSQNDVLVWGSNKNYNLGIGNEQNTNAPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGQENSLPAPKRVKVSSKLGDDSIRHISVSRQHSLVLTNRSLVFACGINTDHQLGVRDANEHLTQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFGISANTPSIMVPTLIKLPAKTTIRFVEANNAATVIYSEEKMITLYYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLPQIKKILYKCNQVMVLSGDGCVYRGKCNQIALPASGLHEKTRGNLDNWQDNDQNKTEISREHVIRIELQRVPNIDRANDIFCDEGFSSFAVLQESHTKYFRKPTLPRREHSFKKLLHDTSDCDAVHDVVFHVDGEKFAAHKFIIFSRAPGLRELIRCYLDKDIYLNLEHLTGKMFELILKYIYTCYWPTEDDIDCIQQSLGPANPQHRTRTCEMFLPHLEKFQLVELAKYVQSYVRDHQFPLPNARQRFSRLHRSDYPELYDVRIVCEDGIVLEAHKCMLVARLEYFEMMFMHSWSERSSVTMEGVTSEYMEPVLDYLYSLETETFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKLLQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNEHYRNMFKRVFDYRQITPFSEAIEDELLLSFVDGCEVDLDYRMDAESQLKQAAKHKQKDLRKQGARHQYEQQAISSMMRSLSVSESAPGSEVPSSPQESARSEVKNWSRVVDKKDQKRKQAETAFKVNNTLKQEEPPTPELIPIERKPQKEQTPPPISSETEPTTPLTKSYNLDFSSLTPQSQKLSQKQRKRLSSESKNWRANNPPLVEQSTPVAVPNAWGVTATPSSSFNDSFTSPTTGGSSDPTSFANMMRGQAASSTTPTEHGQSFSRILADERRQRESYERMRNKSLVHTQIEETAIAELREFYNVDNIDDETITIARMSRPSDINFSTWLRQ