Ddif001666.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila differens
Gene Symbol
-
Assembly
GCA_037043665.1
Location
JBAMAZ010000022.1:3724604-3728194[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.14 9.2 6.9 0.0 1 13 357 369 357 377 0.81
2 8 0.00042 0.027 14.9 1.5 1 21 726 746 726 747 0.95
3 8 0.00089 0.058 13.8 3.4 1 23 764 786 764 786 0.97
4 8 0.00011 0.0072 16.7 6.5 1 23 792 814 792 814 0.97
5 8 3.9e-05 0.0025 18.1 0.9 1 23 820 842 820 842 0.98
6 8 0.00063 0.041 14.3 1.4 1 23 848 870 848 870 0.98
7 8 0.012 0.76 10.3 0.0 2 23 877 898 876 898 0.96
8 8 0.018 1.2 9.7 0.1 3 21 906 924 904 925 0.91

Sequence Information

Coding Sequence
ATGACGCCAGCAGCTGTTGAGGATGGGCGTGAGAAATGCGGCAGCGTCTACACTTGGAACTGTGCTGGCGAACTCTATGGCATCGAGTGTGAGCTGTGCGAGGAGCGACCCCTTTGTGCACTCGATGAGTTTGCCGAGCATATGGAGCTGTGGCACTCTGACTGGCAACAGGCACCGGAGGATGAGCTTATGCAGGAGGTGCTCGCCGAACAGTCCAGCAGCAACTGCGAGGTCAATGAACTCAAACAGCAGCTAGTTCAAGAGCTCAACTCACACgataaacagcaacagcaacagcaaccacagcagcaaccacagcagcaaccacagcagcagccacagctgaTGGACACATTTCAACTGAACGATCAAGTTCAGTTCAATGCGGATagtGGCCTGCCCAGTGTGGAAACGGCAGCGAAGCTGACGACGGAGCATGTGCAGCAGCTGATTGAGCTATATCGATCGCATCCGCGACTGTGGGATCAATCGCATCCAGAGTTCCGGGACGTGGAGCAGTGTCGCCACTCGTGGCGCCAGATAACGGATGCGTGGAGTGCCCACTGTGGACGTGGCTTCAGTGTGACCGATGTGCGCATCCGGATCTCAACGCTGTGCCAGCGATTCCTCAAGCAGCGTGAACGCATCGATGCCGAGGGTGATCTCGATGAGGGCGCCAAATTCGTTCACTACGATCAGTTGCGTTTCCTCTGTGAGCAGCAGGCGCTGCTGAAGCGCCAGGAGCACTTTGCCCGCGAGAATCGCAAACTGCTCGAGATCTACGAGCATTATCCAATACTCTGGCACAATGCCCACAAGCGATTGCGCTGCGCCGCAACGGTGAAGAGGCGCCACGAGGCACACCGTGGCCTCCAGCTGGCGTTGCGTATGTGCGGCATTAATCTGTCCGGCTTGGCGATGCAGCGGCGACTCCAGTCGCTGAGGAAACGCTATCGCCTGGAGAAGATACGCTATCTGCACAGTGTCGTCGAGGGCAAACAATCGGAATTTGTGTCCATCTTTGAGCATTATGCCGAAATGGAGTTTCTGCACAAGCACATCGATCCCTATGTCTGTGCTGGCTGCGGCAAGATCTTTGAGAATCTGATCGGTCATCAGGCGCATGTGCAAGATAGCTGCGAGGAGCAATCGCTGGCTGCAGCCGACTGCAAACAGTTGACCGAACCGGAGGCGACGCTGGGCGAGCTTATggtgcagctggagcagcacgaattacagcagcagcaacaccagcaacatcagcagcagcagcagcaacagcagcagtctgCCGGAGAAGAAACCGAACAGCTGCAGGTAGTGGAGCAAgtggaacagcagcaggagcagctggtggcagctgcaacaactgaGCTGGCCACGCCACTGCTGCATAGTCTAGCCGAACCGGAGGATGCGCAGCAGGCGGAGATTGAGCAGCATCCTGACAAAGAAGATCCGCACGGCAAGGAGTCCTTCTCCGAGGATAGCCTGTCGACGGGTGGACAGCTACGCATGCGCCTCAGCCTGGAGCTGACCAATAAACTGATTGAACTCTATCAATCGCATCCAAATCTCTGGGATCCCAATCATCTGGACTATCATGCGAGGAAACAGCGACGCCAGGCCTGGCACAACATTGCCGCCCAGCTGAACACATTTGCCGGCTGTCCGGATCGCTTTAGCTGGCAGATGCTGCATCGCAAGCTCACCGACTATGTCAAGTACTATCGACGCGAACGCCAGCGAGAGGAGCTGGCGGTTGGAGGTGGTGGCGAGGGCACACGTTGGGGCTTCTACGAGGCGTTCAGCTTTATGGACGATGTGGTGCCGATAAATCGTGTGCTGCAGAAATCATTGCAGCAGCGCGACAGCAATCTGAAGATCATCCAGGTGTATCAGAGCTACGAGCAGCTGTGGTGCACCACACATCCGGATTATACGAAACGTAAGCAGCGCTTGCGGCACCTGGAATCGCTGTGCACCCGCCTGCAGGAGGAATGCAATCTGCAGATAACCGTTGAGCGTTTAAAGAGTCGTCTGATCGAGTTTCGCTGCCAGTATCGTCAGTGCAAGGAGGCACGCCAGGCGGCGCTGCAGCGCAACAATGCCAACTGGCAGCCGACCTATGAGTATTATGCGCCGTTGCAGTTTCTCGAACTGCACGTGTCGCCGTTCAACTGCGAACGGTGCACGGCGAGCTTTAAGCGGCGCAGCGATTATCTGCGGCATCAGCGCAACCGACGCCGTCGCATGCGACGTGGCACGAATGCGACAAATCCGCTGGAGCACATCTGTCACATTTGCGCAATGAAATTCTCGTTGCGCACCAGCCTCCAGGCGCATCTGCGTCGCCATTTGGGGCAGCGGACACACTGTTGCACCGACTGTCCCAAGAAGTTCTTCAATTCGACCTCGTTGCGGGTGCACCAGCGCAGCCATACCAAAGAGCTGCCGTATGTGTGCGAGCATTGTGCCCGGGGCTTTGTCAATGCCAGCAAACTGAATCAGCATGTTAAGCGGCATACGGAGAAACGGGATTATCCGTGCACCCGCTGCGACAAGGCGTTCTATACGGCACACGAGCGAGATCGCCACTTGCGCGCCCATCTCAACATTAGGGACAAGGTGTGTCCGTATTGCAGTCGGGCCTTTGTCGTTGGCAGCGCCTATTATGCCCATCTAAATTTGCATCGGGGCGAGAAGCGTTATGGCTGTGCCGCATGTGGCAAGCGATTCGCTCAGTATGCTGGTCTCTATAAGCATCGCAAGCGCTGCACAATCGCCCAGCTGCAGGAGAAGTGa
Protein Sequence
MTPAAVEDGREKCGSVYTWNCAGELYGIECELCEERPLCALDEFAEHMELWHSDWQQAPEDELMQEVLAEQSSSNCEVNELKQQLVQELNSHDKQQQQQQPQQQPQQQPQQQPQLMDTFQLNDQVQFNADSGLPSVETAAKLTTEHVQQLIELYRSHPRLWDQSHPEFRDVEQCRHSWRQITDAWSAHCGRGFSVTDVRIRISTLCQRFLKQRERIDAEGDLDEGAKFVHYDQLRFLCEQQALLKRQEHFARENRKLLEIYEHYPILWHNAHKRLRCAATVKRRHEAHRGLQLALRMCGINLSGLAMQRRLQSLRKRYRLEKIRYLHSVVEGKQSEFVSIFEHYAEMEFLHKHIDPYVCAGCGKIFENLIGHQAHVQDSCEEQSLAAADCKQLTEPEATLGELMVQLEQHELQQQQHQQHQQQQQQQQQSAGEETEQLQVVEQVEQQQEQLVAAATTELATPLLHSLAEPEDAQQAEIEQHPDKEDPHGKESFSEDSLSTGGQLRMRLSLELTNKLIELYQSHPNLWDPNHLDYHARKQRRQAWHNIAAQLNTFAGCPDRFSWQMLHRKLTDYVKYYRRERQREELAVGGGGEGTRWGFYEAFSFMDDVVPINRVLQKSLQQRDSNLKIIQVYQSYEQLWCTTHPDYTKRKQRLRHLESLCTRLQEECNLQITVERLKSRLIEFRCQYRQCKEARQAALQRNNANWQPTYEYYAPLQFLELHVSPFNCERCTASFKRRSDYLRHQRNRRRRMRRGTNATNPLEHICHICAMKFSLRTSLQAHLRRHLGQRTHCCTDCPKKFFNSTSLRVHQRSHTKELPYVCEHCARGFVNASKLNQHVKRHTEKRDYPCTRCDKAFYTAHERDRHLRAHLNIRDKVCPYCSRAFVVGSAYYAHLNLHRGEKRYGCAACGKRFAQYAGLYKHRKRCTIAQLQEK