Bcon011032.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Bombus confusus
Gene Symbol
Lztr1
Assembly
GCA_014737475.1
Location
JACXIV010000017.1:409242-418985[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 4.7e-13 1.2e-10 41.3 0.3 3 108 352 494 350 496 0.87
2 5 2.4 6.1e+02 0.4 0.0 77 108 495 526 493 528 0.89
3 5 1.8e-12 4.5e-10 39.5 0.0 9 55 588 632 579 644 0.84
4 5 0.00092 0.23 11.4 0.1 52 96 655 701 635 717 0.73
5 5 1.2 3e+02 1.4 0.0 76 100 715 739 710 748 0.79

Sequence Information

Coding Sequence
ATGGATAACGTTGCGACAGCAGAGTGTTTGACTCTTGATTTTGGTCCTTTTGAAACTGTCCATCGCTGGCAACGTATGCCAGAATGTGACGAATTCGTTGGTGCCAGGCGTAGCAAACATACTGTTGTAGCATACAAAGATGCGATCTATGTTTTTGGTGGCGATAATGGTAAAAGAATGTTGAATGATTTATTGAGATTTGATGTAAAAGAAAAGTCCTGGGGACGTGCATTTGCAACAGGAGCACCTCCTGCTCCAAGATATCATCATTCTGCAGTTGTGCATGACTCATCCATGTTTGTATTTGGTGGTTACACTGGTGACATACATTCCAATTCAAATCTTACAAATAAGAATGACCTATTTGAGTACCGATTCCAAACTGGCCAATGGACAGAATGGAAATTTATTGGGAAGACTCCTGTAGCTAGATCTGCACATGGAGCTGCTGTATATGATAATAAATTATGGATATTTGCTGGTTATGATGGTAATGCAAGATTAAACGATATGTGGACAATATCATTATTACCTGGAGAACCAAGAGTATGGGAAGAGGTTGTTCAGTCTGGCGACTGTCCACCAACGTGTTGTAACTTTCCTGTTGCAGTAGCACGCGAATCCATGTTTGTATTCAGTGGCCAGAGTGGAGCTAAGATCACAAATAGTCTCTTTCAATTCCACTTTCGAGAAAGGCGATGGACGCGAATTTCAACGGAGCATATACTTCGTGGTGCACCGCCTCCGCCAGCGCGACGATATGGTCACACCATGGTTAGTTTTGATAGACATCTTTACGTGTTTGGTGGTGCAGCTGATTCTACGTTACCCAACGATCTTCACTGCTATGATCTCGATACGCAAACATGGAATATTATTTTGCCATCTGCTGATAGTCAGATTCCTTCTGGTCGACTGTTTCACGCAGCAGCGGTAATCGGAGAAGCAATGTTCATTTTCGGTGGAACAGTCGACAATAATGTCCGATCTGGGGAAACGTACCGATTCCAATTTTCGTCTTATCCAAAATGTACCTTACATGATGATTTCGGAAGGTTGTTGAACGGGCGCCTTTTCTGTGATGTAGAATTTATAGTAGGAGATACAGAAACCAAAATACCTGCTCACATAGCTATGGTAGCGGCTCGTTCGCAATTTCTTAGGACGCGCATTAGACAAGCTCGAGAGAAACGAGATAAACATTTAGAGGAAGTTTTTGGAACTGCAGATGTACCGATCAAAGATATGCCACTGTTAGAAGTAAGACTGAAAGATGCTGTCCCAGAGGCATTTGAGATGGTTCTTAACTATATTTACACCGATCGTATCGATCCAACAAAAAGAAGCGAAGATGGGTCGAGCAGTCGTGTCGAAGACCCATTAAGCAATCGAATTGTGCTTCTTATGATGGATGTCTATCGTTTAGCTTTGCAATTCAATATGAAACGATTGGAGCAGCTGTGCGTTCAATATCTGAAAGCGACTATAAGTCACGCTAACGTTTTAGAAGCATTGCATAATGCCGCTCACTTAAAATTATATTTTATAAAGGAGTTTTGCTTGAGTTTCATTGTAAAAGAAATCAATTACAATCAAATTGTAATGAGCAAGGAATTTGAAACCTTGGATCAACCTTTGATGGTAGAAATTATTAGAAAAAGACAAATGCCTCAAAGAGGTGTATTTCCTAGGCAGTGCGATCTTAGTACAGGGACGACTTTGGAACAGGACATGGAGGCATTTCTTAAAAATGTGGGCAGAGAATTCTGTGATATAACGCTTATGTTAGATGGCGTGCCAATTCCAGCTCACAAGGCCATTCTTGCGGCGCGTTGTAGCTATTTTGAGGGGATGTTTCGCTCTTTTATGCCTGAAAATAATACAGTGAACGTAAGATGTCGATCCTTACATATTTGTTTATTTATGGCTATTAAATATAATTTAATAAAACATGCGTCTTTACAACAGATACAAATCGGCGAAATGATTCCATCTTCCGAGTCATTCGACTCCTTATTAAGGTATATTTATTACGCGGACGTTTCAATGCCGCCCGAAGACTCTTTATATTTATTTACCGCTCCAGTTTTTTATGGTTTTACAAATAATCGACTGCAAGCGTTTTGCAAACAGAATCTTGAGATGAATGTCACTTTTGAGAACGTCATACAGATCTTGGAAGCTGCGGATAGGATGCAAGCTGTTGACATGAAGAAATACGCATTGAATCTTATTGTGCATCACTTTACAAAGGTTGCAAGGCTACCAAGGTTAAAGCAATTAAGTCGTGAACTTTTATTGGATATCTTAGAAGCATTGGCTGATGAACGTAGCGAGGCACGAACATGTCAGGACATGGCGAATGATTGCTGA
Protein Sequence
MDNVATAECLTLDFGPFETVHRWQRMPECDEFVGARRSKHTVVAYKDAIYVFGGDNGKRMLNDLLRFDVKEKSWGRAFATGAPPAPRYHHSAVVHDSSMFVFGGYTGDIHSNSNLTNKNDLFEYRFQTGQWTEWKFIGKTPVARSAHGAAVYDNKLWIFAGYDGNARLNDMWTISLLPGEPRVWEEVVQSGDCPPTCCNFPVAVARESMFVFSGQSGAKITNSLFQFHFRERRWTRISTEHILRGAPPPPARRYGHTMVSFDRHLYVFGGAADSTLPNDLHCYDLDTQTWNIILPSADSQIPSGRLFHAAAVIGEAMFIFGGTVDNNVRSGETYRFQFSSYPKCTLHDDFGRLLNGRLFCDVEFIVGDTETKIPAHIAMVAARSQFLRTRIRQAREKRDKHLEEVFGTADVPIKDMPLLEVRLKDAVPEAFEMVLNYIYTDRIDPTKRSEDGSSSRVEDPLSNRIVLLMMDVYRLALQFNMKRLEQLCVQYLKATISHANVLEALHNAAHLKLYFIKEFCLSFIVKEINYNQIVMSKEFETLDQPLMVEIIRKRQMPQRGVFPRQCDLSTGTTLEQDMEAFLKNVGREFCDITLMLDGVPIPAHKAILAARCSYFEGMFRSFMPENNTVNVRCRSLHICLFMAIKYNLIKHASLQQIQIGEMIPSSESFDSLLRYIYYADVSMPPEDSLYLFTAPVFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADRMQAVDMKKYALNLIVHHFTKVARLPRLKQLSRELLLDILEALADERSEARTCQDMANDC