Basic Information

Gene Symbol
-
Assembly
GCA_950022955.1
Location
OX465577.1:4742151-4745105[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.97 1.4e+02 4.8 7.1 1 23 83 105 83 105 0.97
2 17 0.16 22 7.3 1.3 1 21 109 129 109 132 0.94
3 17 1.3 1.8e+02 4.4 0.5 3 21 139 157 137 158 0.93
4 17 2.5 3.5e+02 3.5 2.4 3 23 166 188 164 188 0.87
5 17 0.00045 0.063 15.3 1.5 1 23 195 218 195 218 0.95
6 17 0.38 53 6.1 1.4 1 23 223 245 223 245 0.95
7 17 0.00051 0.072 15.1 1.8 3 23 305 326 304 326 0.98
8 17 2 2.8e+02 3.8 0.0 2 23 351 373 350 373 0.92
9 17 0.00087 0.12 14.4 0.2 2 23 397 418 396 418 0.96
10 17 0.00034 0.047 15.7 0.8 1 21 422 442 422 443 0.96
11 17 0.82 1.1e+02 5.0 0.1 1 23 484 507 484 507 0.94
12 17 1.2 1.7e+02 4.5 0.2 2 23 533 555 532 555 0.94
13 17 0.0017 0.24 13.5 0.6 2 23 579 600 578 600 0.95
14 17 0.00025 0.035 16.1 0.0 1 23 604 627 604 627 0.97
15 17 0.46 64 5.8 0.5 1 23 631 654 631 654 0.97
16 17 0.00038 0.053 15.5 1.9 1 23 693 716 693 716 0.96
17 17 0.00079 0.11 14.5 0.4 1 23 726 749 726 749 0.95

Sequence Information

Coding Sequence
ATGGATGTCCAGCACAAGCAATTCACAGTCGCTACAGCCTTCCACCACATGAGCACCCTAAAAGAATATCTCAAATGCGATATCACCAACTTAAAATGCAGACTGTGTTACCATCCTTGTGAAAAAATCGATGATTTCACCCAACATTTCACAACCAAACACGTAAGAACTCATGGAGAAGTTGTGAAGAAACTGAAGCTTGAATATGATGTGGGGTTACAACCTTACCGATTAGTGAATAATAACTATTGTTGCTATCATTGTGGCAAGAAAATGCCCACTCTTATCAAACTCTGTAGACACACTATTTCGCATTACCAGCGGTACACATGCGATACATGTGGACGCAACTACCTGTCTCTAGAAGCGTTGAGATACCACATCAAATGCATCCATGAAGTTACTAAACACCTCTGCAGAAAATGCTGGACGGAATTCCCCACtttagaaaagaagaaagaacaTATAAGGGCATCAAAGCAATGCTGGACTTTTTGCTGCATTGTCTGTGCGGAGAGATTCCAATCTTGGGAGCATAAGCAGAAACATTTGCAAGCTGAACATGGCTACGAGCAAATAGTCTATGACTGTCCTGACTGTGAAGAAAAattcacttcgagaaagtattTTTATACTCATTACAAGCTAGCTCACACTGATGAAGGCTTTCAATGTGCTTGCTGCGGTCTCAAATTTAACACCCAGAAACGGTTAGACGATCATGCACTTGTACATACTGGAGAGAAGGAGTTTATGTggacCACATTGGAAATTCACGGACGTAGTGAGACTGagaatgaaacaaaaaagaaaattgtcCTTGTTTACCAGACGCCCCAAAGGCGAAACGCTGAAATTATACTAACTTATTCCACCGCGTACCCTTTTAAAACTCGTTTTAGTCAAATACTATGCTCGTATTGCCATGAGGAATATAACACTCTCACAGATCTCAGATATCATATGAAAACAGAACATATTAATTCAGGTTTCAAAAACGTTTTCTACAGAGCAAGggataatttaatcaaaatcgaTATTACAAATCTCGAATGTAAAATTTGCTCAGAAGAAATTCAAGATGTCGATGGTCTTATGAGCCATTTGTATAGAGAACATAATAAGCCTGTAAAATTTAATGCCCGCTACGGTGTTCTACCTTATAAGCAGAATTCTGATAACCACTGGACCTGTGTTTACTGTAACAAAATCTTCATTTCTTTCATAGCATTCAATCGGCACATTGTTACTCATTTCATGAATTATAGTTGTGATAAATGTGGAACAACTTTCGTCTCTGATTACGCCTTAAAAGACCATCATCGGCAAGTCAAGTGCTTTCGAACAGCTTATAAAGCTAGAAATGGTCGAGTCTTAAAACCTAGATCTAATGCCGAAATTATTCTACAATGTTCCACAGCTAGTCCTTTCAGGACATGGAAAAGTAACTTCAATTGTGTTTTCTGTAGGGTTCAAAGTAACGATCCAAGCGGTCTTCGTATGCATGTCGTCACAATTCATGCGAATTACGacgttaaagctgctttttATAAGAAATTAGGGAAAGATTTCCTCAACGTTGATATCACAGATCTCCAATGTAAGCTATGCTTCATGCCTATAGACTCCTTCGACAGTTTGATCTACCATTTAAAGAACGATCATCAGCAACCGATAAATAGTGATGCCCAGATAGGAGTCCTACCGTTTAGACTGAACGATGGGTCGATATGGAAATGCACGATATGTCCGAACGAATTCAAAGATTTCGTCTCGTTAAAGAAACATACATCAGAACACTTCCAAAACTACGTTTGTGATACTTGTGGTGAAGGTTTTATCACAGAATCTGCTATGATTGCACACACTAAAATACCACACGAGAATAAATATAACTGCAGTCGATGTATAGCCACGTTCTCTTCGCTAGATGAAAGGAATATTCACGTGAAAACACAGCATACATCACTGCCTTACGTGTGTGTCTATTGCAAAGATAAACCACGCTTCGCAAACTGGGAGGTTCGCAAAAAACATTTGATGGCGGTTCATAATTATAAAACGGGAGCAGATAAATACGATTGCACGACGTGCCAAAAGTCTTTCAAGACGAGATCGGGGAAGTACAATCACATGGCAAGAGTGCATCGGATTAAAAAAGACACTGAACTCAGTTATCCGTGTCCAAGTTGTCCCAAGGCTTTTACGACTAAACTGTTCTTGGATAAACATGTGGCTAAAAAGCATTTTGATGTTTGA
Protein Sequence
MDVQHKQFTVATAFHHMSTLKEYLKCDITNLKCRLCYHPCEKIDDFTQHFTTKHVRTHGEVVKKLKLEYDVGLQPYRLVNNNYCCYHCGKKMPTLIKLCRHTISHYQRYTCDTCGRNYLSLEALRYHIKCIHEVTKHLCRKCWTEFPTLEKKKEHIRASKQCWTFCCIVCAERFQSWEHKQKHLQAEHGYEQIVYDCPDCEEKFTSRKYFYTHYKLAHTDEGFQCACCGLKFNTQKRLDDHALVHTGEKEFMWTTLEIHGRSETENETKKKIVLVYQTPQRRNAEIILTYSTAYPFKTRFSQILCSYCHEEYNTLTDLRYHMKTEHINSGFKNVFYRARDNLIKIDITNLECKICSEEIQDVDGLMSHLYREHNKPVKFNARYGVLPYKQNSDNHWTCVYCNKIFISFIAFNRHIVTHFMNYSCDKCGTTFVSDYALKDHHRQVKCFRTAYKARNGRVLKPRSNAEIILQCSTASPFRTWKSNFNCVFCRVQSNDPSGLRMHVVTIHANYDVKAAFYKKLGKDFLNVDITDLQCKLCFMPIDSFDSLIYHLKNDHQQPINSDAQIGVLPFRLNDGSIWKCTICPNEFKDFVSLKKHTSEHFQNYVCDTCGEGFITESAMIAHTKIPHENKYNCSRCIATFSSLDERNIHVKTQHTSLPYVCVYCKDKPRFANWEVRKKHLMAVHNYKTGADKYDCTTCQKSFKTRSGKYNHMARVHRIKKDTELSYPCPSCPKAFTTKLFLDKHVAKKHFDV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00685734;
80% Identity
-