Basic Information

Gene Symbol
MBD2_1
Assembly
GCA_902151445.1
Location
CABFVZ010000347.1:280555-292998[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.3e-25 3.3e-21 76.8 0.1 4 73 8 72 5 75 0.92
2 2 0.0011 11 7.8 0.1 28 74 89 148 77 151 0.82

Sequence Information

Coding Sequence
ATGAAGATGAGTCACGAAAAGAAAAAGTTCGAGTGCACTGGTTTGCCAAAAGGTTGGCAAAGGGAAGAAGTCATCAGGAAATCTGGTCTTTCTGCTGGAAAGGTTGACGTGTATTATTACAGTCCTAATGGGCAGAAGTTTCGCAGCAAGGCTCAGCTCGCCCAATATCTGGGCAATACTCTTGATCTCGCCACTTTTGATTTCCGTACAGGCAAAGTAAACTCATTGCTTCTGCGTAAACACAAGAAACAGAGAGGGACCCAATTTGACTACAGCCGAGGTGTGAGGAATGATGCATCACTGGTCCCCCCTATTCGTCAGACAGCATCCATCTTCAAGCAGCCAGTGACTGTGTACAAGACTCAGGAGGGCAAGGTGAAGACCGACTTCAAGCATGGACCCCAGGAGAAACCCAAGCAGTTATTCTGGGAGAAACGGCTGGAAGGGCTTCGCGCATGTGACGTTGATGGAAAGGAGTTTGATGCAATGGAGCTACCTCGTGCCCTTCGAGCTGTAGGGCCCCATGTGGGAGAAGACACACTGCTTCAGTCCATAGCCACAGCGCTGCACATGTCTGCCCAACCTGTCACGGGACAGACAGGTTCCCGGTCTGCTCTTGACAAGAACCCTGGGGTGTTCCTCAACCCTGAGCAACCACTGGTGCAGGTATGTGTTGCATCATGCCTAACTTTGATCTGA
Protein Sequence
MKMSHEKKKFECTGLPKGWQREEVIRKSGLSAGKVDVYYYSPNGQKFRSKAQLAQYLGNTLDLATFDFRTGKVNSLLLRKHKKQRGTQFDYSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKTDFKHGPQEKPKQLFWEKRLEGLRACDVDGKEFDAMELPRALRAVGPHVGEDTLLQSIATALHMSAQPVTGQTGSRSALDKNPGVFLNPEQPLVQVCVASCLTLI*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01343982;
90% Identity
iTF_01447587;
80% Identity
iTF_01445674;