Basic Information

Insect: Temnothorax americanus
Gene Symbol: MBD-R2
Assembly: GCA_030770215.1
Location: JASTWO010000071.1:396006-405351[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.8e-17 3e-13 50.3 0.2 8 69 523 584 517 592 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.8e-17	3e-13	50.3	0.2	8	69	523	584	517	592	0.92

Sequence Information

Coding Sequence: ATGGGAATGGCGCGCAAATGCTGCGTGCGAAGCTGCAAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGACTGCCGCTGCACAAGTTCCCCAAGGACGCCGCGCTGAGGGACAGGTGGTTGGCCAGCGGCGGCTTCGAGGAGAGTTTCAAGCCGACGCCAGGCCAGGTCGTCTGCCATAGGCATTTCAAACGCGCCGACTACGAGACCGCGCGGGGCGGTCACAAGCTCCTGCTCAGGAGGGGCAGCGTGCCCACGGTGTTCGCGGACTACGACGAGCATCCCGATCCTGTAATTATGTCCGTGAAGTCTTCTACATCCTACGCTCAAGAAGACTTGGACCTGATCAATTCGGAAATACTAAATTTGGAACATTCTGCCTCGCCGTTGTTATCCGAGGCGAGAACACCTAAATCCGACAGTTGCGGCGAGACTTGTTATTCTAGACCCGAGTCGTCGGCAGACTCCTTAAATCTCCCTGACAGCACGGAAGTAACGGATAATGAATATAAAGCGACAAATCCAAGAGAAGAGAGCAAGGTATCCGCGAAGGACAGATCGACCGAGAATTCGGTCGACAATAAAGTGAACACAGTAGCGATGCAACTTGGTATCGTCGAACCGGAAACGGCAATGAAGACCGGTGCCAAAGACCTAAAGGAAGCATTAAAATTACCCGGCGACAAGGAATTCGACAAATCGGAAGAATTGAAACCAAAGGTTTTGAATCGTGGCGGTTTGAAATTTTTCCCCGGTGCCAAATTGGAAGCGAAAGACTTTAACGAAAAGTGGTATTCCGCAAAAGTGGTAGAAACAGATTGGGACGAAAGGGAAGTTTTGATACACTTCGACAAGTGGAGTTCGAGATTTGACGAATGGATACCGATGGACAGCTCCAGGCTTCGCGTATTGCAATCCCCACAAAACGAACAAGCTTGGACCCCGCCATCTCCGGAGGCGAAGATGAGGGAGTTCTCCGTGGGAGAGCGGATACTCGCTACGTGGGCGGACGGCAAAAAATATCCAGCCAAAGTGAGCGCGGTCCTGACGAATGACAGGTACAACGTGCTGTTCGACGATGGATACGCGAAGATCGTCAAGTCGTCGAAAATGACCAAGATCGCCGCAAATCCGACCAAGCAATTAAACGAAGTGGATGGATATATCGGCAGCAAACAAGAAAGAAGGGATAAGAAACGGAGGCACACAGTTATGGAGTTGTTTAACATTCACTCGAGGAAACGCACGAAACACGATACTGAGAAAGCACCAAAGAAGGATGAAACTGTCGTCAAGGAAAGTGGTGAAGGCTCTGCGGAGAGCAAGATTGAGATGGATGGTACCCTATATGGTCCCTGTTACGATCCAGGGACAGATTTGTTGAAAGGTTTCGAAACCAGTTCCTTGAAAATCAAATCGTATTCGAAGAAAAGCAAGAAGGAAGTACCCAAGATCGAAACGGATCCTGAGGAAAACGTCGGTCCCGAATGGATTGATGGAGAGCCACGAGGAACAGAATCTTATATCGTAGATGGTAATGATGGACCACGCCGATCTATAATAGTACCAGATAAGAGATTGCCTGCCGGTTGGGAAAAACACTTTACGCAAAGGAAAGCTGGCTCATCTGCTGGAAAATGGGACGTCTTGTTTATACAtaaGCAGACCGGGAAGAAGTTCAGATCAAGAAATGACATCAGAGTATTTATGGAGAATCAGGGGCAGTACGATTTCGACCCTGAAAAATTCGACTTTTGTATACATCGCAGGAAGCGAAACCATGCTCATCGTGTGAAGCAGGAAGTTACACCGGAGGCACCAAAGAAGATCAAAACTTTATTGCCTAAAACGAAAACGTCCACACCAGAGACTACATTACTTCCTACAATGACGAGCAGTATCGATACTCCAGTTATCCCCTCGACGCCTACTACATCTACTACAGATGGTGCCGTCTTTATTGGACTTCGTGGTGGACTTCGTGTGGAAATGGAAGACAGCGCTTATAAATGTCCCAAGGAAGGATGCAACAAGAATTTTCGAAAGGAAAATTTACTGCAGATGCATATCAAGCATTACCATCCTGAATATTCCAAGTTTCTGGGTTCTACTCCCAAAGTTGAAGATCTGGCTTACGCAAGAACGATTGGGGAATCTGTAGAGGATATAAttccaaaaaaatcaataacgttctcagagaaaataaataaatccgcGAAGAAGAAATCTCTTCCTGAGAAATCATCGTCTACTTTACTACAATCAGCGGTTAATACTATGCAACCGACATTTCCGTTAATACCTGGTCCGATGATGCCGGAAGAAGTGGAATTGGATCAGTCAGAAAAGTGTAATGATTTGCAGAAGGAAGATACGAAACTTGAAACAATGTCACAAATATCTAATCACAGTATGGAGATAGACGACGATATtgaaaggaaaagagaaaacgtCTGCGCGTTGTCCCCTGGTACATTATTTGACATGAGAGTGAAAGAGGAAAAAGCGCAGGGTGGGATTAAAACGCTATTGCCTGTAAGACCAGTTGCGACATCGGAGGCGCAAAGAGCCGACAGGACGAAATCTTTGGATGAAACGGCGCACGGTGAGCGTGTAAAAAACCAGAAGAAAAAGCAACTTACCGAACATAGCGTGGACTTGCCGGCTAAAGCAAAAAAACGACATGGTATGTCAGATCTTACCGACAATTTTGGTGATCAAGACGACAGTGCTATGGACGTCGAAGGACCTACGGCACTTATGTATAGATATAGCCGTAGAAAATCTGACTCAAAGAGCGACGAAAATAGTCAGAATAGTCAACTAAATGATTCACGCATTGAAAAAGCTGATCCCTTAAAAGGGGATGCAATCAAAacagatattaataatgatgCAGAAGGAAGCGAAGGAGTGATGATGATGATTAACGGGGAACTGGTAAAAGTAGAACAACTTCGgagagaagaaataataaattgcacaTGTGGTTTTATGGAAGAGGACGGTTTAATGATACAGTGCGATCTCTGTCTCTGCTGGCAACATGgacattgtaattttattgaaaaggaaaaggacGTTCCTGAGAAATACATTTGTTATGTATGTCAAAATCCGTATCGACTACGGCCGtctaagaaatattatcaCGATCAGGACTGGATTAAGGAAGGAAAATTGTCAagctTGTCTAACCGAACTCGAAATCAGCATAAGATAAATCAAAGGACTGCAATGTTGAAGCGTTCTTATGACTTGGTTGCTGCACTTTTACAAATTCAACAACTTCTTCACAGTCTGCGCGTAAAAATCAACGTGGCAGAaaagaaaGATCACCCGAAATTATATCTTTGGGCCAAGAATTGGGAGAAAATGGATGTACCAAAGATAGACATGGAACCGGTACCAGTGATGGAAATAACTAAAGCGGCGAGTTTTACCGATACAAATTCGGAGATTCCGCGACGTGTCGAGACGAAGGCAGATATCAAGCTGTCTATAAAAGACGATCAAGATGAAAAATCAATCGCTTCCGATTCGGAATTGATGAAAATTTTGGAAGAAGATAGCACGCATTCTGATGAATCCAGGATTATCAGCAAGAAGGAAGGCTCGAATTCAAAGGACAGTCATATACTTTTAGACGCGTTAACGGGTGGTAACTCGGAcataaaagaggaaaagagtGCTACATCAGACATTAAAACGGAGAGTGcagatttATTAGCTGAGAAAACTATTATTGATGATCCCGTATCTGAGAATCTCAATTCTGGATCGCCTGTTAACAACGTTCAACAAGAATCAAGCATAAGCAACGTAAAAAATGAAGTCTCCGCGCTTCCGCAGCCTTTTATACCAGAACCCGAGGCACCGATTGATCCAGCTGAATGCCGAATGCGATTGTTAGAGCATATTGAGCATTTTCAGTGTCACATCGATTCGAGATTAACATCCATAGAAGCGCAAATTTTTGCTCTAGAAGCGATGGACCCGGATGAACTCGTATCGGATCCGCTTGTTCAACCCCGTACTAAGCAGACTGTACAAATGCTCCTTCGTGACTTGAATACGGTCCGGAAACTAGCAGCATTGTGTTGA
Protein Sequence: MGMARKCCVRSCKADVREARAKGLPLHKFPKDAALRDRWLASGGFEESFKPTPGQVVCHRHFKRADYETARGGHKLLLRRGSVPTVFADYDEHPDPVIMSVKSSTSYAQEDLDLINSEILNLEHSASPLLSEARTPKSDSCGETCYSRPESSADSLNLPDSTEVTDNEYKATNPREESKVSAKDRSTENSVDNKVNTVAMQLGIVEPETAMKTGAKDLKEALKLPGDKEFDKSEELKPKVLNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQSPQNEQAWTPPSPEAKMREFSVGERILATWADGKKYPAKVSAVLTNDRYNVLFDDGYAKIVKSSKMTKIAANPTKQLNEVDGYIGSKQERRDKKRRHTVMELFNIHSRKRTKHDTEKAPKKDETVVKESGEGSAESKIEMDGTLYGPCYDPGTDLLKGFETSSLKIKSYSKKSKKEVPKIETDPEENVGPEWIDGEPRGTESYIVDGNDGPRRSIIVPDKRLPAGWEKHFTQRKAGSSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFDPEKFDFCIHRRKRNHAHRVKQEVTPEAPKKIKTLLPKTKTSTPETTLLPTMTSSIDTPVIPSTPTTSTTDGAVFIGLRGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESVEDIIPKKSITFSEKINKSAKKKSLPEKSSSTLLQSAVNTMQPTFPLIPGPMMPEEVELDQSEKCNDLQKEDTKLETMSQISNHSMEIDDDIERKRENVCALSPGTLFDMRVKEEKAQGGIKTLLPVRPVATSEAQRADRTKSLDETAHGERVKNQKKKQLTEHSVDLPAKAKKRHGMSDLTDNFGDQDDSAMDVEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRIEKADPLKGDAIKTDINNDAEGSEGVMMMINGELVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNFIEKEKDVPEKYICYVCQNPYRLRPSKKYYHDQDWIKEGKLSSLSNRTRNQHKINQRTAMLKRSYDLVAALLQIQQLLHSLRVKINVAEKKDHPKLYLWAKNWEKMDVPKIDMEPVPVMEITKAASFTDTNSEIPRRVETKADIKLSIKDDQDEKSIASDSELMKILEEDSTHSDESRIISKKEGSNSKDSHILLDALTGGNSDIKEEKSATSDIKTESADLLAEKTIIDDPVSENLNSGSPVNNVQQESSISNVKNEVSALPQPFIPEPEAPIDPAECRMRLLEHIEHFQCHIDSRLTSIEAQIFALEAMDPDELVSDPLVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00730116;
90% Identity: iTF_01405789; iTF_00385317; iTF_00385473; iTF_01423717; iTF_01423658; iTF_01422987; iTF_01422928; iTF_01421556; iTF_01421608; iTF_01422232; iTF_01422279; iTF_00765581; iTF_00765648; iTF_00885107; iTF_01408216; iTF_01408296; iTF_01409113; iTF_01409204; iTF_01407389; iTF_01407282;
80% Identity: iTF_01405789;