Tbic008150.1
Basic Information
- Insect
- Tetramorium bicarinatum
- Gene Symbol
- MBD-R2_1
- Assembly
- GCA_011636605.1
- Location
- VBVP01004691.1:39-8596[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.33 2.2e+03 -1.1 0.0 43 60 410 427 409 448 0.75 2 2 1.7e-17 1.1e-13 51.1 0.3 8 69 555 616 549 624 0.92
Sequence Information
- Coding Sequence
- ATGAAGCGGCGGCGTATACCGCGCTCGCGTGCCGAGGGGAGGGTATCGTCCGCCGTaaccgcggcggcggcggcggtgacggcggcggcgggggCGATGGGAATGGCGCGCAAATGCTGCGTGCGTAGCTGCAAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGACTGCCGCTGCACAAGTTCCCCAAGGACGCCGTGCTGAGGGACAGGTGGTTAGCCAGCGGCGGCTTCGAGGCGGGTTTCAGACCGACGCCAGGCCAGGTCGTCTGCCACAGGCATTTCAAACGCGCCGACTACGAGGCCGCGCGGGGCGGTCACAAGCTTCTGCTCAGGAGGGGCAGCGTGCCCACGGTTTTTGCCGACTATGACGAGCATCCCGATCCTGTTATTATGTCAGTGAAGTCTTCTACATCCTACGCTCAAGAAGACTTGGACCTGATCAATtcggaaatattaaatttggaaCATTCTGCCTCACCATTATTATCTGAGGCGAGAACACCTAAATCTGACAGTTGCGGGGAGACATGTTATTCTAGACCTGAATCGTCGGCAGACTCCTTAAATCTCCCCGACAGTTCGGAAGTAACAGATAATGAATACAAAGTAGTAAATCTGAAGAAAGAGAGCAAGGTATCCATGAAGGACAAATCGACGGAAAATTCGGATAATAAAGTGAATACAGTAGCGATGCAGCTTGGTATCGTCGAATCGGAAACAGCAATGAAGACTGGTGCCAAAGATCTAAaggaagaattaaaattatccgaCAACAAAGAATTTGACAAATCGGAAGAATTGAAACCAAAAGTTTTGAATCATCGTGGtggtttgaaattttttcctgGTGCCAAATTGGAAGCGAAAGACTTTAATGAAAAGTGGTATTCTGCAAAAGTGGTAGAAACAGATTGGGATGAAAGGGAAGTTTTGATTCACTTTGACAAGTGGAGTTCGAGATTTGATGAATGGATACCGATGGATAGCTCCAGACTTCGTGTACTGCAAACCCCACAAAAcgAACAAGCTTGGATCCCACCATCTCCGGAGGCGAAGATGAGGGAATTCTCGGTGGGCGAGCGGATACTTGCTACGTGGGCGGATGGCAAAAAGTATCCAGCCAAAGTGAGCGCGGTCCTGACGAATGACAGGTACAATGTGCTGTTCGACGATGGATACGCGAAAATCGTCAAATCGTCGAAAATGACCAAGATCGCTGCAGATCCGATCAAGCAAATGAGCGAAGTGGATGGATATATCGGCAGCAAACAAGAAAGACGGGATAAGAAACGGAAGCACACAGTTATGGAGTTGTTTAACACTCATTCAAGGAGACGCACAAAGCACGAGGCTGATAAAACACCAAAGAAGGAGGAAACTGTTAGCAAGGAAAGCGGCGAAGGCTGTACAGAGAACAAAGTCGAGATGGACGGCACTCAATATGGTCCCTGTTACGATCCAGGGACAGATATGTTGAGAGGTTTCGAAACCAATTCCACGAAAATCAAATCGTATTCAAAGAAAAGTAAGAAGGAAGTGCCCAAGGCTGATGTGGATCCTGAGGAAAATGTTGGTCCTGAATGGATTGACGGAGAACCACAGGGAACAGAATCTTATATTGTAGATGGCAATGATGGACCACGTCGATCTATAATAGTACCTGACAAGAGATTGCCTCCCGGGTGGGAAAAACACTTTACGCAAAGGAAAGCTGGCACATCTGCTGGAAAATGGGACGTCTTGTTCATACAtaagcAGACTGGGAAAAAGTTTAGATCAAGAAATGACATCAGAGTATTCATGGAGAATCAAGGACAGTATGATTTCGATCCTGAAAAATTTGACTTTTGTATACATCGAAGGAAGCGAAACCATACGAATCGTGTGAAACAGGACGTTACACCGGAGGTACCAAAGAAGATCAAAACTTTACTGCCTAAAACGAAAACGGCCACACCTGAGAATACATTACTTACTCCGGTGACGAACAACATTGACACTCTACCTATCACTTCAACGCCTACTACTTCTACAGATGGAGCCGTCTTTATTGGACTTCGTGGCGGACTTCGTGTGGAAATGGAGGACAGCGCCTATAAATGTCCGAAGGAAggatgcaataaaaattttcgaaaagaaaatttgctGCAAATGCATATCAAGCATTACCATCCTGAATATTCCAAGTTTCTAGGCTCTACTCCCAAAGTTGAAGATCTAGCTTATGCAAGAACGATCGGTGAATCTATAGAAGATATAATTCCCAAAAAATCAACGACGTTcttagagaaaataaataaatccgcCAAAAAGAAATCTCTTCCTGAGAAATCATCGTCTACTTTGTTGCAATCAGCGCTTAATACCATACAACCGACATCTCCGTCAATGCCTGATTCAATAGTGCCGGAGGAAGAAGAGGTGGATCAATCAGAAAAGTGTAATGATTCGCAGAAGGAGGATTTGAAACTTGAAACAATGTCACCAATATCTAATCACAGTATGGAGATAGACGAtgatattgaaagaaaaagagataatgtCTGCGCGTTGTCTCCTGGTACACTATTTGACATGAaagtgaaagaagaaaaagcgcAGGGTGGCATTAAAACGTTATTGCCTGTAAGATCAGTTGCGACATCAGAAGTGCAAAGAACCGATAGGTCGAAACCTCTGGAAGAAATGGCGCACGGTGAGCGTGTAAAAAaccaaaaaagaaaacaacttACCGAACATAATGTGGATTTGCCGACTAAAGTAAAGAAACGACATgGTATGTCAGATCTTATCGATAGTTTCGGTGATCTAGACGACAGTGCTATGGACGTCGAAGGACCTACGGCTCTTATGTATAGATACAGCCGTAGAAAATCTGACTCAAAGAGCGATGAAAATAGTCAGAATAGTCAGCTAAATGATTCACGCATTGAAAAAGCTGATCCCCTAAAAGGGGATGCAATCAaaacagatattaataatgatgcaGAAGAGAGCGAAGGAGTGATGATGATGATTAACGGCGAATTGGTAAAAGTAGAACAACTTCggagagaagaaataataaattgtacatgtGGCTTTATGGAAGAAGATGGTCTAATGATACAGTGCGATCTTTGTCTCTGCTGGCAACATGgtcattgtaatttaattgaaaaggaaaaggatGTTCCCGAGAAATACATTTGTTACATATGTCGAAATCCATATCGACTACGGCcgtctaaaaaatattatcatgatCAGGATTGGATTAAGGAAGGAAAATTGCCaagcTTGTCTAATCGAACTCGGAATCAGTATATGATAAATCAAAGGACTGCAATGTTGAAGCGTTCTTATGATTTGGTTGCTGCACTTTTACAAATGCAACAACTTCTTCACAGTCTGCGCGTAAAAATCAATGTGGCAGAaaaaaaagatcatCCAAAACTATATCTTTGGGCCAAGAATTGGGAGAAAATGGATGTACCAAAGGTAGACATGGAGCCAGTACCAGTGATGGAAATAACTAAGGCGGCAAGTTTTACCGATACAGGTTCAGAGATTCCACGACGTATCGAGACGAAGGCGGATATCAAGTTGTCTATAAAAGACGATCAAGATGAAAAATCAATCGCTTCTGATTCggaattgatgaaaattttggAAGAGGATAGCACACATTCTGATGAATCCAGAATTATGAGCAAGAAGGAAGGCTCGATGAATTCAAAGGACAGTCACATACTTTTAGATGCATTAACGGGTGGTAACACggatataaaagagaaaaacatgGTCACATCAGACATTAAAACAGAGAGCACaggtacaataatataa
- Protein Sequence
- MKRRRIPRSRAEGRVSSAVTAAAAAVTAAAGAMGMARKCCVRSCKADVREARAKGLPLHKFPKDAVLRDRWLASGGFEAGFRPTPGQVVCHRHFKRADYEAARGGHKLLLRRGSVPTVFADYDEHPDPVIMSVKSSTSYAQEDLDLINSEILNLEHSASPLLSEARTPKSDSCGETCYSRPESSADSLNLPDSSEVTDNEYKVVNLKKESKVSMKDKSTENSDNKVNTVAMQLGIVESETAMKTGAKDLKEELKLSDNKEFDKSEELKPKVLNHRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTPQNEQAWIPPSPEAKMREFSVGERILATWADGKKYPAKVSAVLTNDRYNVLFDDGYAKIVKSSKMTKIAADPIKQMSEVDGYIGSKQERRDKKRKHTVMELFNTHSRRRTKHEADKTPKKEETVSKESGEGCTENKVEMDGTQYGPCYDPGTDMLRGFETNSTKIKSYSKKSKKEVPKADVDPEENVGPEWIDGEPQGTESYIVDGNDGPRRSIIVPDKRLPPGWEKHFTQRKAGTSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFDPEKFDFCIHRRKRNHTNRVKQDVTPEVPKKIKTLLPKTKTATPENTLLTPVTNNIDTLPITSTPTTSTDGAVFIGLRGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESIEDIIPKKSTTFLEKINKSAKKKSLPEKSSSTLLQSALNTIQPTSPSMPDSIVPEEEEVDQSEKCNDSQKEDLKLETMSPISNHSMEIDDDIERKRDNVCALSPGTLFDMKVKEEKAQGGIKTLLPVRSVATSEVQRTDRSKPLEEMAHGERVKNQKRKQLTEHNVDLPTKVKKRHGMSDLIDSFGDLDDSAMDVEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRIEKADPLKGDAIKTDINNDAEESEGVMMMINGELVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNLIEKEKDVPEKYICYICRNPYRLRPSKKYYHDQDWIKEGKLPSLSNRTRNQYMINQRTAMLKRSYDLVAALLQMQQLLHSLRVKINVAEKKDHPKLYLWAKNWEKMDVPKVDMEPVPVMEITKAASFTDTGSEIPRRIETKADIKLSIKDDQDEKSIASDSELMKILEEDSTHSDESRIMSKKEGSMNSKDSHILLDALTGGNTDIKEKNMVTSDIKTESTGTII
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00730116;
- 90% Identity
- iTF_01405695;
- 80% Identity
- iTF_01421608;