Basic Information

Insect: Temnothorax rugatulus
Gene Symbol: MBD-R2
Assembly: GCA_035220575.1
Location: JASTWL010000196.1:14476-23535[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3e-17 1.8e-13 51.3 0.3 8 69 562 623 556 631 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3e-17	1.8e-13	51.3	0.3	8	69	562	623	556	631	0.92

Sequence Information

Coding Sequence: ATGAAGCGGCGGCGTATACCGCGCTCGCGTGCCGAGGGGAGGGTATCGTCCGCCGTaaccgcggcggcggcggcagcagcggcggcggcggcggcggcggcggcggcgggggcgATGGGAATGGCGCGCAAATGCTGCGTGCGTAGCTGCGAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGACTGCCGCTGCACAAGTTCCCCAAGGACGCCGCGCTGAGGGACAGGTGGTTGGCCAGCGGCGGCTTCGAGGAGAGTTTCAGGCCGACGCCAGGCCAGGTCGTCTGCCATAGGCATTTCAAACGCGCCGACTACGAGACCGCGCGGGGCGGTCACAAGCTCCTGCTCAAGAGGGGCAGCGTGCCCACGGTGTTCGCGGCGGACTATGACGAGCATCCCGATCCTGTAATTATGTCCGTGAAGTCTTCTACATCCTACGCTCAAGAAGACTTGGACTTGATCAACTCGGAAATACTAAATTTGGAACATTCCGCCTCACCGTTGTTATCCGAGGCGAGAACACCTAAATCCGACAGTTGCGGCGAGACTTGTTATTCTAGACCCGAGTCGTCGGCAGACTCCTTAAATCTCCCTGACAGCACGGAAGTAACGGATAATGAATATAAAGCGACAAATCCGAAAGAAGAGAGCAAGGTATCCGTGAAGGACAAATCGACCGAGAATTCGGTCGATAATAAAGTGAATACAGTAGCGATGCAACTTGGTATCGTCGAACCAGAAACGGCAATGAAGACTGGTGCCGAAGACCTAAAGGAAGAATTAAAATTACCCGGCAGCAAGGAATTCGACAAATCGGAAGAATTGAAACCAAAGGTTTTGAATCGTGGTGGTTTGAAATTTTTCCCCGGTGCCAAATTGGAAGCGAAAGACTTTAACGAGAAGTGGTATTCTGCAAAAGTGGTAGAAACGGATTGGGATGAAAGGGAAGTTTTGATACACTTCGACAAGTGGAGTTCGAGATTTGATGAATGGATACCGATGGATAGCTCCAGGCTTCGCGTATTGCAATCCCCACAAAACGAACAAGCTTGGATCCCGCCATCTCCGGAGGCGAAGATGAGGGAGTTCTCCGTGGGAGAGCGGATACTCGCTACGTGGGCGGACGGCAAAAAATATCCAGCTAAAGTGAGCGCGGTCCTGACGAATGACAGGTACAACGTGCTGTTCGACGATGGATACGCGAAAATCGTCAAGTCGTCGAAAATGACCAAGATTGCCGCAAATCCGACCAAGCAATTAAACGAAGTGGATGGATATATCGGCAGCAAACAAGAAAGAAGGGATAAGAAACGGAGGCACACAGTTATGGAGTTGTTTAACATTCACTCAAGGAAACGCACAAAACACGATACTGAGAAAACACCAAAGAAGGAGGAAACTGTCGTCAAGGAAAGTGGTGAAGGCTCTGTGGAGAGCAAGATCGAGATGGATGGTACCCTATATGGTCCCTGTTACGATCCAGGGACAGATTTGTTGAAGGGTTTCGAAACCAATTCCTTGAAAATCAAATCGTATTCGAAGAAAAGCAAGAAGGAAATACCCAAGATCGAAACGGATCCTGAGGAAAACGTCGGTCCTGAATGGGTTGATGGAGAGCCACGAGGCACAGAATCTTATATTGTAGATGGTAATGATGGACCACGCCGATCTATAATAGTACCAGACAAGAGATTGCCTCCCGGTTGGGAAAAACACTTTACGCAAAGGAAAGCTGGCTCATCTGCTGGAAAATGGGACGTCTTGTTTATACAtaaGCAGACCGGGAAGAAGTTCAGATCAAGAAATGACATCAGAGTATTTATGGAGAATCAAGGGCAGTACGATTTCGACCCTGAAAAATTCGACTTCTGTATACATCGCAGGAAGAGAAACCACGCTCATCGCGTGAAGCAGGAAGTTACACCGGAGGCACCAAAGAAGATCAAAACTTTATTGCCTAAAACGAAAACGTCCACACCTGAGACTACATTACTTCCCACAATGACGAGCAGTATCGATACTCCAGTTATCCCCTCGACGCCTACTACATCTACTACCGATGGTGCCGTCTTTATTGGACTTCGTGGTGGACTTCGTGTGGAAATGGAAGACAGCGCTTATAAATGTCCCAAGGAAGGATGCAACAAGAATTTTCGAAAGGAAAATTTACTGCAGATGCATATCAAGCATTACCATCCTGAATATTCCAAGTTTCTGGGCTCTACTCCCAAAGTTGAAGATCTGGCTTACGCAAGAACGATTGGGGAATCTATAGAGGATATAATTCCCAAAAAATCAATAACGTTcttagagaaaataaataaatccgcGAAGAAGAAATCTCTTCCTGAGAAATCATCGTCTACTTTATTACAATCAGCGGTTAATACTATGCAACCGACATCTCCGTCAATACCTGGTCCGATGATGCCGGAAGAAGTGGAATTGGATCAGTCAGAAAAGTGTAATGATTCGCAGAAGGAAGATACGAAACTTGAAACAATGTCACAAATATCTAATCACAGTATGGAGATAGACGACGATATTGAAAGGAAAAGAGACAACATCTGCGCGTTGTCCCCTGGTACATTATTTGACATGAAAGTGAAAGAGGAAAAAGCGCAGGGTGGCATTAAAACGCTATTGCCTGTAAGACCAGTTGCGACATCGGAGGCGCAAAGAGCCGACAGGACGAAATCTTTGGATGAAATGGCGCACGGTGAGCGTGTAAAAAACCAGAAGAAAAAGCAACTTACCGAACATAGCGTGGACTTGCCGGCTAAAGCAAAAAAACGACATGGTATGTCAGATCTTACCGACAATTTTGGTGATCTAGACGACAGTGCTATGGACGTCGAAGGACCTACGGCACTTATGTATAGATATAGCCGTAGAAAATCTGACTCAAAGAGCGACGAAAATAGTCAGAATAGTCAACTAAATGATTCACGCATTGAAAAAGCTGATCCCTTAAAAGGGGATGCAATCAAAACAGATATTAATAATGATGCAGAAGAGAGCGAAGGagtgatgatgatgattaaCGGCGAAATGGTAAAAGTAGAACAACTTCGGagagaagaaataataaattgcacaTGTGGTTTTATGGAAGAGGACGGTTTAATGATACAGTGCGATCTCTGTCTCTGCTGGCAACATGGacattgtaattttattgaaaaggaAAAGGATGTTCCTGAGAAATACATTTGTTACATATGTCAAAATCCATATCGACTACGGCCGTCTAAGAAGTATTATCACGATCAGGACTGGATTAAGGAAGGAAAATTGTCaagctTGTCTAACCGAACTCGAAATCAGTATAAGATAAATCAAAGGACTGCAATGTTGAAGCGTTCTTATGACTTGGTTGCTGCACTTTTACAAATTCAACAGCTTCTTCACAGTCTGCGCGTAAAAATCAACGTGGCACAAAAGAAAGATCACCCGAAACTATATCTTTGGGCTAAGAATTGGGAGAAAATGGATGTACCAAAGATAGACATGGAACCGGTACCAGTGATGGAAATAACTAAAGCGGCGAGTTTTACCGATACAAATTCGGAGATTCCGCGACGTGTCGAGACGAAGGCAGATATCAAGCTGTCTATGAAAGACGATCAAGATGAAAAATCAATCGCTTCCGATTCGGAATTGATGAAAATTTTGGAAGAAGATAGCACGCATTCTGATGAATCCAGGATTATCAGCAAGAAGGAAGGCTCGAATTCAAAGGACAGTCATATACTTTTAGACGCGTTAACGGGTGGTAACGCGGACATAAAAGAGGAAAACAGTGCTACGTCAGACATCAAAACGGAGAGTGCAgATTTATTAGCTGAGAAAACTATTATTGGTGATCCCGTATCTGAGAATCTCAATTCTGGATCGCTTATTAACAACGTTCAACAAGAATCAAGCATAACCAACTTGGAGCATATTGAGCATTTTCAATGTCACATCGATTCGAGATTAACATCCATAGAAGCGCAAATTTTTGCTCTAGAAGCAATGGACCCGGATGAACTCGTATCGGATCCGCTTGTTCAACCCCGTACTAAGCAGACTGTACAAATGCTCCTTCGTGACTTGAATACGGTCCGGAAACTAGCAGCATTGTGTTGA
Protein Sequence: MKRRRIPRSRAEGRVSSAVTAAAAAAAAAAAAAAAAGAMGMARKCCVRSCEADVREARAKGLPLHKFPKDAALRDRWLASGGFEESFRPTPGQVVCHRHFKRADYETARGGHKLLLKRGSVPTVFAADYDEHPDPVIMSVKSSTSYAQEDLDLINSEILNLEHSASPLLSEARTPKSDSCGETCYSRPESSADSLNLPDSTEVTDNEYKATNPKEESKVSVKDKSTENSVDNKVNTVAMQLGIVEPETAMKTGAEDLKEELKLPGSKEFDKSEELKPKVLNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQSPQNEQAWIPPSPEAKMREFSVGERILATWADGKKYPAKVSAVLTNDRYNVLFDDGYAKIVKSSKMTKIAANPTKQLNEVDGYIGSKQERRDKKRRHTVMELFNIHSRKRTKHDTEKTPKKEETVVKESGEGSVESKIEMDGTLYGPCYDPGTDLLKGFETNSLKIKSYSKKSKKEIPKIETDPEENVGPEWVDGEPRGTESYIVDGNDGPRRSIIVPDKRLPPGWEKHFTQRKAGSSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFDPEKFDFCIHRRKRNHAHRVKQEVTPEAPKKIKTLLPKTKTSTPETTLLPTMTSSIDTPVIPSTPTTSTTDGAVFIGLRGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESIEDIIPKKSITFLEKINKSAKKKSLPEKSSSTLLQSAVNTMQPTSPSIPGPMMPEEVELDQSEKCNDSQKEDTKLETMSQISNHSMEIDDDIERKRDNICALSPGTLFDMKVKEEKAQGGIKTLLPVRPVATSEAQRADRTKSLDEMAHGERVKNQKKKQLTEHSVDLPAKAKKRHGMSDLTDNFGDLDDSAMDVEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRIEKADPLKGDAIKTDINNDAEESEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNFIEKEKDVPEKYICYICQNPYRLRPSKKYYHDQDWIKEGKLSSLSNRTRNQYKINQRTAMLKRSYDLVAALLQIQQLLHSLRVKINVAQKKDHPKLYLWAKNWEKMDVPKIDMEPVPVMEITKAASFTDTNSEIPRRVETKADIKLSMKDDQDEKSIASDSELMKILEEDSTHSDESRIISKKEGSNSKDSHILLDALTGGNADIKEENSATSDIKTESADLLAEKTIIGDPVSENLNSGSLINNVQQESSITNLEHIEHFQCHIDSRLTSIEAQIFALEAMDPDELVSDPLVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00730116;
90% Identity: iTF_01405695;
80% Identity: iTF_01408296;