Basic Information

Insect: Tetramorium immigrans
Gene Symbol: MBD-R2
Assembly: GCA_011636585.1
Location: VBVO01003678.1:4985-13744[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.4 1.6e+04 -3.8 0.0 43 59 403 419 403 433 0.77

2 2 1.9e-17 1.3e-13 51.0 0.3 8 69 548 609 542 617 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.4	1.6e+04	-3.8	0.0	43	59	403	419	403	433	0.77
2	2	1.9e-17	1.3e-13	51.0	0.3	8	69	548	609	542	617	0.92

Sequence Information

Coding Sequence: ATGAAGCGGCGGCGTATACCGCGCTCGCGTGCCGAGGGGAGGGTATCGTCCGCCGTAACCGCGGCGGCGGGGGCGATGGGAATGGCGCGCAAATGCTGCGTGCGTAGCTGCAAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGACTGCCGCTGCACAAGTTCCCCAAGGACGCCGCGCTGAGGGACAGGTGGTTGGCCAGCGGCGGCTTCGAGACGGGTTTCAGGCCGACGCCAGGCCAGGTCGTCTGCCACAGGCATTTCAAACGCGCCGACTACGAGGCCGCGCGGGGCGGTCACAAGCTTCTGCTCAGGAGGGGCAGCGTGCCCACGGTTTTTGCCGACTATGACGAGCATCCCGATCCTGTTATTATGTCAGTGAAGTCTTCTACATCCTACGCTCAAGAAGACTTGGACTTGATCAATtcggaaatattaaatttggaaCATTCTGCCTCACCATTATTATCTGAGGCGAGAACACCTAAATCTGACAGTTGCGGGGAGACGTGTTATTCTAGACCTGAATCGTCGGCAGATTCCTTAAATCTCCCCGACAGTTCGGAAGTAACAGATAATGAATACAAAGTAGTAAATCTGAAGAAAGAGAGCAAGGTATCCATGAAGGACAAATCTACAGAAAATTCGGATAATAAAGTGAATACAGTAGCGATGCAGCTTGGTATTGTCGAATCGGAAACAGCAATGAAGACTGGTGCCAAAGATCTAAaggaagaattaaaattacccGACAACAAAGAATTTGACAAATCGGAAGAATTGAaaccaaaagttttgaatCATCGTGGtggtttgaaattttttcctgGTGCCAAATTGGAAGCGAAAGACTTTAATGAAAAGTGGTATTCTGCAAAAGTGGTAGAAACAGATTGGGATGAAAGGGAAGTTTTGATTCACTTTGACAAGTGGAGTTCGAGATTTGACGAATGGATACCAATGGATAGCTCCAGACTTCGTATATTGCAAACCCCACAAAAcGAACAAGCTTGGATCCCACCATCTCCGGAGGCGAAGATGAGGGAATTCTCAGTGGGCGAGCGGATACTCGCTACGTGGGCGGATGGCAAAAAGTATCCAGCTAAAGTGAGCGCGGTCCTAACGAATGACAGGTACAATGTGCTGTTCGACGATGGATACGCGAAGATCGTCAAATCGTCGAAAATGACCAAGATCGCCGCAGATCCGATCAAGCAATTGAGCGAAGTGGATGGATATATCGGCAGCAAACAAGAAAGACGGGATAAGAAACGGAAGCACACAGTTATGGAGTTGTTTAACACTCACTCAAGGAGACGCACAAAGCACGATGCTGATAAAACACCAAAGAAAGAGGAAACTGTCGTCAAGGAAAGTGGCGAAGGCTCTACAGAGAACAAAGTCGAGATAGACGGCACTCAATATGGTCCCTGTTATGATCCAGGGACAGATATGTTGAGAGGTTTCGAAACTAATTccacgaaaataaaatcgtattcAAAGAAAAGCAAGAAGGAAGTGCCCAAGGCTGATGTGGATCCTGAGGAAAATGTTGGTCCTGAATGGATTGACGGAGAACCACAGGGAACAGAATCTTATATTGTAGATGGCAATGATGGACCGCGTCGATCTATAATAGTACCTGACAAGAGATTGCCTCCCGGGTGGGAAAAACACTTTACGCAAAGGAAAGCTGGCACATCTGCTGGAAAATGGGATGTCTTGTTCATACAtaagcAGACTGGGAAAAAGTTTAGATCAAGAAATGACATCAGAGTATTCATGGAGAATCAAGGGCAGTATGATTTCGATCCTGAAAAATTCGACTTTTGTATACATCGCAGGAAGCGAAACCATACGAATCGCGTGAAACAGGACGTTACACCAGAAGTACCAAAGAAGATCAAAACTTTACTGCCTAAAACGAAAACGGCCACACCTGAGAGTACATTACTTACTCCGGTGACAAACAACATTGACACTTTACCTATCATCTCGACGCCTACTACTTCTACTACAGATGGAGCCGTCTTTATTGGACTTCGTGGCGGACTTCGTGTGGAAATGGAAGACAGCGCTTATAAATGTCCGAAGGAAGGCTGCAATAAgaattttcgaaaagaaaatttgctgCAGATGCATATCAAGCATTATCATCCTGAATATTCCAAGTTTCTGGGCTCTACTCCCAAAGTTGAAGATCTGGCTTATGCAAGAACAATCGGTGAATCTATAGAAGATATAATTCCCAAAAAGTCAACGACGTTcttagagaaaataaataaatccgcCAAAAAGAAATCTCTTCCTGAGAAATCATCGTCTACTTTATTACAATCAGCGCTTAATACTATACAACCAACATCTCCGTCAATCCCTGATTCAATAGTACCGGAGGAAGAAGAAGTGGATCAATCAGAAAAGTGTAATGATTCGCAGAAGGAGGATTTGAAACTTGAAACAATGTCACCAATATCTAATCACAGTATGGAGATAGACGAtgatattgaaagaaaaagagagaatgtcTGCGCGTTGTCTCCTGGTACACTATTTGACATGAaagtgaaagaagaaaaagcacAGGGTGGCATTAAAACGCTATTGCCTGTAAGATCAGTTGCGACATCAGAAGTGCAAAGAGCCGATAGATCGAAACCTCTGGAAGAAATGGCGCACGGTGAGCgtgtaaaaaatcaaaaaagaaaacaacttACCGAACATAATGTGGATTTGCCGACTAAAGTAAAGAAACGACATgGTATGTCAGATCTTACCGATAGTTTCGGTGATCTAGATGACAGTGCTATGGACGTCGAAGGACCTACGGCTCTTATGTATAGATATAGCCGTAGAAAATCCGACTCAAAGAGCGATGAAAATAGCCAGAATAGTCAGCTAAATGATTCACGCATTGAAAAAGCTGATCCCCTAAAAGGGGATGCAATCAaaacagatattaataatgatgcaGAAGAGAGCGAAGGAGTGATGATGATGATTAACGGCGAATTGGTAAAAGTAGAACAACTTCggagagaagaaataataaattgtacatgtGGCTATATGGAAGAGGACGGTTTAATGATACAGTGCGATCTTTGTCTCTGCTGGCAACATGgtcattgtaatttaattgaaaaggaAAAGGATGTCCCCGAGAAATACATTTGTTACATATGTCGAAATCCATATCGACTACGGCcgtctaaaaaatattatcatgatCAGGATTGGATTAAGGAAGGAAAATTGCCAagCTTGTCTAATCGAACTCGGAatcaatatatgataaatcaaAGGACTGCAATGTTGAAGCGTTCTTATGACTTGGTTGCTGCACTTTTACAAATGCAACAACTTCTTCACAGTCTGcgcgtaaaaattaatgtggcACAaaaaaaagatcatCCAAAACTATATCTTTGGGCCAAGAATTGGGAGAAAATGGATGTACCAAAGGTAGACATGGAGCCAGTACCAGTGATGGAAATAACTAAGGCGGCAAGTTTTACCGATTCAGGTTCAGAGATTCCACGACGTATCGAAACGAAGGCGGATATCAAGTTGTCTATAAAAGACGATCAAGATGAAAAATCAATCGCTTCTGATTCggaattgatgaaaattttggAAGAGGATAGCACACATTCTGATGAATCCAGAATTATGAGCAAGAAGGAAGGCTCGATGAATTCAAAGGACAGTCACATACTTTTAGATGCATTAACGGGTAGTAACACggatataaaagagaaaaacattgTCACGTCAGATATTAAAACAGAAAGCACAGATTTGTTAGCTGAGAAAACTGTTGATAATTCCACATCTGAAAATCTCAATTCTGGATCGCTTATCGACAACGTTCAACGAGAATCGAATATAGCTGACGTCAAAAATGACGTCTCCGCCCTTCCACAGCCTTTTATACCAGAGCCTGAAGCGCCGATTGACCCAGCTGAATGCCGAATGCGATTGTTGGAGCATATCGAGCATTTTCAATGTCATATTGATTCGAGATTAACGTCAATAGAAGCACAAATCTTTGCTCTAGAGGCGATGGATCCGGATGAGCTTGTATCAGATTCACTTGTTCAACCTCGTACTAAGCAGACGGTACAAATGCTCCTTCGTGACTTGAATACGGTCCGGAAACTGGCAGCATTGTGTTGA
Protein Sequence: MKRRRIPRSRAEGRVSSAVTAAAGAMGMARKCCVRSCKADVREARAKGLPLHKFPKDAALRDRWLASGGFETGFRPTPGQVVCHRHFKRADYEAARGGHKLLLRRGSVPTVFADYDEHPDPVIMSVKSSTSYAQEDLDLINSEILNLEHSASPLLSEARTPKSDSCGETCYSRPESSADSLNLPDSSEVTDNEYKVVNLKKESKVSMKDKSTENSDNKVNTVAMQLGIVESETAMKTGAKDLKEELKLPDNKEFDKSEELKPKVLNHRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRILQTPQNEQAWIPPSPEAKMREFSVGERILATWADGKKYPAKVSAVLTNDRYNVLFDDGYAKIVKSSKMTKIAADPIKQLSEVDGYIGSKQERRDKKRKHTVMELFNTHSRRRTKHDADKTPKKEETVVKESGEGSTENKVEIDGTQYGPCYDPGTDMLRGFETNSTKIKSYSKKSKKEVPKADVDPEENVGPEWIDGEPQGTESYIVDGNDGPRRSIIVPDKRLPPGWEKHFTQRKAGTSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFDPEKFDFCIHRRKRNHTNRVKQDVTPEVPKKIKTLLPKTKTATPESTLLTPVTNNIDTLPIISTPTTSTTDGAVFIGLRGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESIEDIIPKKSTTFLEKINKSAKKKSLPEKSSSTLLQSALNTIQPTSPSIPDSIVPEEEEVDQSEKCNDSQKEDLKLETMSPISNHSMEIDDDIERKRENVCALSPGTLFDMKVKEEKAQGGIKTLLPVRSVATSEVQRADRSKPLEEMAHGERVKNQKRKQLTEHNVDLPTKVKKRHGMSDLTDSFGDLDDSAMDVEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRIEKADPLKGDAIKTDINNDAEESEGVMMMINGELVKVEQLRREEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNLIEKEKDVPEKYICYICRNPYRLRPSKKYYHDQDWIKEGKLPSLSNRTRNQYMINQRTAMLKRSYDLVAALLQMQQLLHSLRVKINVAQKKDHPKLYLWAKNWEKMDVPKVDMEPVPVMEITKAASFTDSGSEIPRRIETKADIKLSIKDDQDEKSIASDSELMKILEEDSTHSDESRIMSKKEGSMNSKDSHILLDALTGSNTDIKEKNIVTSDIKTESTDLLAEKTVDNSTSENLNSGSLIDNVQRESNIADVKNDVSALPQPFIPEPEAPIDPAECRMRLLEHIEHFQCHIDSRLTSIEAQIFALEAMDPDELVSDSLVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00730116;
90% Identity: iTF_01405695;
80% Identity: iTF_01422279;