Basic Information

Gene Symbol
L
Assembly
GCA_944452685.1
Location
CALYBZ010002098.1:28929-41904[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 8e-06 0.00078 20.7 1.7 1 23 226 248 226 248 0.98
2 18 0.67 65 5.2 5.8 1 23 254 276 254 276 0.98
3 18 3.5e-07 3.4e-05 25.0 3.1 1 23 282 304 282 304 0.99
4 18 1.6e-05 0.0016 19.7 0.3 1 23 310 332 310 332 0.98
5 18 5 4.9e+02 2.4 0.8 2 23 397 420 396 420 0.84
6 18 0.0028 0.27 12.7 0.2 2 23 448 470 447 470 0.96
7 18 0.042 4.1 9.0 0.7 1 23 571 593 571 593 0.97
8 18 0.17 17 7.1 2.9 2 23 601 622 600 622 0.96
9 18 0.00049 0.047 15.1 0.4 1 23 630 654 630 654 0.94
10 18 0.17 16 7.1 0.1 1 19 659 677 659 679 0.93
11 18 4 3.9e+02 2.7 0.6 1 23 689 712 689 712 0.91
12 18 0.0018 0.18 13.3 1.2 1 23 751 774 751 774 0.98
13 18 0.0012 0.12 13.8 4.8 2 23 990 1012 989 1012 0.97
14 18 0.18 17 7.0 0.1 1 23 1018 1040 1018 1040 0.92
15 18 0.04 3.9 9.0 0.6 2 23 1048 1069 1048 1069 0.96
16 18 1.1 1.1e+02 4.5 0.5 2 23 1160 1181 1160 1181 0.94
17 18 0.009 0.88 11.1 0.2 1 23 1191 1213 1191 1213 0.97
18 18 0.015 1.5 10.4 0.7 1 23 1220 1242 1220 1242 0.95

Sequence Information

Coding Sequence
ATGTACTCCACACATACTTCGTCAAGTTATTCACCTTCCATATCAGATGGTACTATTACACCAAATTCCTTACATCATCATCATCTTCACCACCACCATCAGCATTTAGCTGTGCCACCACATTTATCATTCCCCAATTCGGCTGCTTATGAAGAAGACACAACATCGTTGGCCCTACAGACACAACGTCTGCCAAGGCAAAAAACTAATGGCACTTTGGATGGCGCTGAGTATGAAGACAACGCCAATGACAACGAAAACGACAACGACAACGACCACAACAACGAAAGAATGCACAAAAATGATGCCAAACTGTGTGAAGACAATGTCACAATTGTTGCCGACAATAAGACAAACGCAAATATTTCTGAAAGTGGCGAAGAAcatcatcagcatcagcatcagcaaccacataatcatcaccatcatcaactaaaacgtcatggtcgtcatcatcgttatgctgaacATGCCTTAAGAATGCCTTCAAAATTACGCAAAATCGATAGGGATTCAACGGTTGGTGGCAATGGAGTCAGTGCCGCCGGTGTTGCTGCTACTGCTGCTGATGGTGTTGGTGGTGGTGTTGGTGTAACAGCAAATGCAGTCAAGTTTGATAAGTTGACAGGAGATGGCATTAAAAGTGGTAATAATGCTGCTAGTGCCGACGGATCCTATCAATGTCAATTCTGTGATAAATCATTTCCGCGTCTTGGTTATTTGAAAAAACATGAACAGAGTCATGCTGAGCATTTGCCGTTCAAATGTGATTACTGTGCACGCCTGTTCAAGCACAAGCGTTCGCGTGACCGCCATACGAAATTGCATACAGGCGATCGTCGTTATCGCTGCCCGCACTGCGAGGCGGCATTTTCAAGAAGTGATCACTTGAAGATTCACATGAAAACGCACGACAACCAAAAACCATTCCAATGTACTATTTGCAATCGTGGCTACAATACTGCTGCGGCACTAACATCCCACATGCAAAATCACAAAAAGCAGGCAGCCCTTTTGGCTGCTGGTGGCAATCCCCAAGCCCTCAATTATAGTCCGCGTTCTACCGGCTCGGCTTCCAGCAATGGCAGCTTACAAAAAAGACGTTATGGTTTGGCAGGAGCAGCCGAACAAAGTCCCACTCGTCTTGAGTATTCCAAAAGAGGTCGTTCGTCATCATCAAATATGCTTAAGTGCACGTTTTGTTCAAAATCTGATTTCACTGCAGTGGAACAGCTTAATACTCATCTGCAGACTCAACACGAAAAAGAACTGGCACATTCCATGACACCACCCTCAACAAATCACCATCAAGCGTTAGAAAATCACAATGCATTCCAGTTGTCATGTGAATATTGTACTATGAAATTTGCTAATATCGCTGCTATGTTTCAGCATATGCGTTCGGCCCATTTGGATCGTTTGACCAGTCCCAATTCTTACTTTGAACATTTCAATCGTTTGGCGGCCTCGGGTACATTTAGTCCACGCCTATTAACGGCACCACCACTAAGAAGTGTGGCCAGTGCAGAAGAAAATATAATTAAAGAAGAAAATAATTTATCAAGTCCCAAGTCAGTGGATGCAGCGAATCGCCAAAATGAAGATGAACCTACTGATTTGAGTCAAAATAATCGCAGATCAATGACACCAGCAAATACTCCCCAAAACTCTCCGCAAGAGCACTTACCGGCCAACGAAAAGCCTGGACTATTCTTCTGCAATCAATGCAATGCCGGCTTGCCCGACTTTGAATCCTTCCGCAATCATTTGAAAACCCACATTGCCCAAGGGCTCAATTTGGTGTGCCACCACTGTGGTATGCTTTTGAGGGAACATTCCGAATATGAAAGACATGTGATATCACATTTTCTCATTACCAATTCGGAATACAATTGCTCGGGAAATTGCCAAAAGTCCTTTGGAAAGCCGGAGGAATTACAAAAACATCTTATGGATCAGCATGCCATAACAATGTTTAAGTGCAGCCTGTGCAGCGAAATGTTCGAATCGAAAGTAGCCATACAAGTACATTTTGCCTGTACACACTCAGCGGAAAGCAAAATCTTTCGTTGTTCGGCCTGCATGGATGTGTTTCGAAGCGAAAACGATTTTAACATACACGTCAAAATGCGCCATCAAGCTGTTAATAATAATGCGGCGCCAGTAAACTCTTTGCAGTGTATGTTTTGTCGCACAATTTGTTCCTCAGACCTGGAGATGCAATTCCACTTGGCCGCACATGCCAGACAATTTCGTTGTCCCTCTTGCCCGGAAACGTTCCATGTCGAATTTCTACTCGATCGTCATATGCAAACACAACATGGTGGTTTAGAGCGTCCACCACCACCACAGCCGCCACCACATCCTCCTCCTCCTCCACCACCTACTGCCCAGCAAACTGTCGCCGAAGAACATACATCTCCCGTAGCCATGCCAAATGCTATATCGCCCATGAACTCTTTGTATGTGAATGCTCTGTTTGGCAAAACGCCTTTAATGCCTCTGGCCCCACAAAATAACAACAACAGTATTTTAGATTACAACATGGCCTTTGCCAGCCACATTAATAAGGGATTGTTTCCCAATGCCAACCCAAACAAGTTCTACAATCCTTTACAAATTGATACAAACGCCATGAAACATTCAGCCTTGATGTACGGTTTATCGCAAAGATATTTCGATACCAATCGCACGGTTATGGAAATGTATCAACAGCAGCAGCAACAACAACAACAACAACAACATCACCCCCACGACAGCAATAAAGCTACAGGAAATTATTTCATAAGTCCTAAACAGCCGGCTGCAGCAGTGCACGACGCCCACCATCCCAGAGATGTGCCCACCTCACCCATTAACAATACCGGCTTTAGTTGTGGCATTTGCGAACGAAATGATTTTCACACCGAGTCCGAAGTCCACTCTCATCGCAAGATTGTACACAATCTAAAGACCGGCGTCAGTCTGAAATGCGCCTATTGCTCGGGCAATTTTAAATCACGCAGTGAACTCGAACACCATATGAAAACCTGTCACAATTCTACCGGCAAGCACAAGTGTCTGATATGCGATGAAATCTTTCCCTCGCCCGCTATACTGGCCGAACATAAGCTACAACACTCCAAGGTGGGACAGTCGGGAAGATGTTCACATTGCTCCAAGGCACTGGCAGATGTCAGTGCTTTCAAAGTTCATTTGAGCGAACACAATACGGAAGGCCAAATGCCAGTGCAGTGCATATGCTGTCGCCAGTCATTACACTCAGAATTTGAGATTGGGCTGCATGCAAAATTCCATGTTATCAACCCCACTGTGCAGGAGAACGTGTGTGCTCTTTGCTTAGAGCCCATCACCCATTCAGCCACTGAGGCCAAAGTTTGCGAAAAATGCTGTCGCAAACACAATCTCAATGCCAAGTTCAAGCCACGTGAACATTTTGAGCGACCTGCCATCGAATTGAAGCAGTACATTGAAAATCGCTGTAATCTGTGCAAAATGATTTTGCCGCATGCCCAAAAACTACAAGAACACTTGGTGGAACATACCTTTGCCGGCTGTGAGGAGCGTGGCTTCAACTGTTACATATGTTCGGCCGTTTTTACAGCTCCTACGGGCCTGCTTCACCACATGCTAGAGCATGGCACTAATGCTAAGCCCTACGATTGCAATCTGTGTCCAGAAAAGTTTTATTTCCGCGCTGAGTTGGACCATCATCTAATCGATCATGAGGTAAGAGCAGCAGCACCGGCAGCAATAAAAACTGAGCAGGAGCTATCAACAAAAAAAGAAGAGACTTTGAATAGCATGAAATCGGAGAAAGCCGCAGTTGGTTTAAGCGCCGTAAAGCAGGAAGTAATGGAAAATGATCATAACGCCAATAATGCTGAAGAGGATGAGTACATTGAAGTGGAAAAGGTACATGAAAATAATAACAACAACAACAATACCAGCAACAGCATGGGCCGTCAAGTGAATGATACAGTGTCGCATAAAACCGAACACACCAGAAATGAATCTAATGAACCAACCAGAGATGAAAAAGCATAA
Protein Sequence
MYSTHTSSSYSPSISDGTITPNSLHHHHLHHHHQHLAVPPHLSFPNSAAYEEDTTSLALQTQRLPRQKTNGTLDGAEYEDNANDNENDNDNDHNNERMHKNDAKLCEDNVTIVADNKTNANISESGEEHHQHQHQQPHNHHHHQLKRHGRHHRYAEHALRMPSKLRKIDRDSTVGGNGVSAAGVAATAADGVGGGVGVTANAVKFDKLTGDGIKSGNNAASADGSYQCQFCDKSFPRLGYLKKHEQSHAEHLPFKCDYCARLFKHKRSRDRHTKLHTGDRRYRCPHCEAAFSRSDHLKIHMKTHDNQKPFQCTICNRGYNTAAALTSHMQNHKKQAALLAAGGNPQALNYSPRSTGSASSNGSLQKRRYGLAGAAEQSPTRLEYSKRGRSSSSNMLKCTFCSKSDFTAVEQLNTHLQTQHEKELAHSMTPPSTNHHQALENHNAFQLSCEYCTMKFANIAAMFQHMRSAHLDRLTSPNSYFEHFNRLAASGTFSPRLLTAPPLRSVASAEENIIKEENNLSSPKSVDAANRQNEDEPTDLSQNNRRSMTPANTPQNSPQEHLPANEKPGLFFCNQCNAGLPDFESFRNHLKTHIAQGLNLVCHHCGMLLREHSEYERHVISHFLITNSEYNCSGNCQKSFGKPEELQKHLMDQHAITMFKCSLCSEMFESKVAIQVHFACTHSAESKIFRCSACMDVFRSENDFNIHVKMRHQAVNNNAAPVNSLQCMFCRTICSSDLEMQFHLAAHARQFRCPSCPETFHVEFLLDRHMQTQHGGLERPPPPQPPPHPPPPPPPTAQQTVAEEHTSPVAMPNAISPMNSLYVNALFGKTPLMPLAPQNNNNSILDYNMAFASHINKGLFPNANPNKFYNPLQIDTNAMKHSALMYGLSQRYFDTNRTVMEMYQQQQQQQQQQQHHPHDSNKATGNYFISPKQPAAAVHDAHHPRDVPTSPINNTGFSCGICERNDFHTESEVHSHRKIVHNLKTGVSLKCAYCSGNFKSRSELEHHMKTCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGRCSHCSKALADVSAFKVHLSEHNTEGQMPVQCICCRQSLHSEFEIGLHAKFHVINPTVQENVCALCLEPITHSATEAKVCEKCCRKHNLNAKFKPREHFERPAIELKQYIENRCNLCKMILPHAQKLQEHLVEHTFAGCEERGFNCYICSAVFTAPTGLLHHMLEHGTNAKPYDCNLCPEKFYFRAELDHHLIDHEVRAAAPAAIKTEQELSTKKEETLNSMKSEKAAVGLSAVKQEVMENDHNANNAEEDEYIEVEKVHENNNNNNNTSNSMGRQVNDTVSHKTEHTRNESNEPTRDEKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01237143;
80% Identity
-