Basic Information

Gene Symbol
Lztr1
Assembly
GCA_963942605.1
Location
OZ012713.1:2129582-2160021[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 6.4e-10 4.5e-07 31.6 0.1 5 106 485 623 481 626 0.79
2 4 1.2 8.3e+02 1.8 0.1 77 109 626 658 618 659 0.84
3 4 3.3e-19 2.3e-16 61.5 0.0 8 95 721 808 715 824 0.85
4 4 0.45 3.2e+02 3.1 0.1 76 105 823 852 813 856 0.81

Sequence Information

Coding Sequence
ATGGGGGTGAATTTAACCGAAAATCGAATTGCAGCTGACGCTTCAGAACTTCCAGTTCAAGTATCTTATGGACCAGAACCTGAAAATCAAAGCGATATTAGCAGCGAAAAAGAAACAAACGAGAACTTTGACACTGAAGTTCCGCTTCCAGAAACCAAGAACTCTGAAGAAGTCGTAAAAGAAGAATTAGTTACTCCAGATTCATCGTACgattttgaatttgtaaattgtataaaaagcgAGCCAATACATGAACCAGAAATCTCTATTTCAAATGTAGATGTTCCACAAATGTCTGtttcagtttcaaatttgcCGCGCGATTTTGAAGACACCAGTCGTGCCGACAGCAGCGCCGAAGTCAGAGTGACAGTTCAAATGGATGCTAGCACATCAAACGCTAGCCAAGTTTTCGACAATGGTTTGACACTTTACTTCGGACCGTTTGAAACCGTTCACCGATGGAAACGAATGCCAGAATGCGATGAATTCGTGGGTGCAAGACGAAGCAAACACACCGTAGTCGCCTACAAGGAAGCCATTTACGTCTTCGGCGGTGATAATGGCAAGAGTATGCTGAATGACTTGTTACGTTTCGATGTGAAAGAGAAGTCGTGGGGTCGTGCATTTGCAACTGGATGTCCCCCAGCGCCAAGGTACCACCATTCCGCTGTGGTTCACGGAACTTCGATGTTTGTTTTTGGGGGGTACACCGGAGACATTCACTCGAATTCTAACCTCACCAACAAGAATGATTTGTTTGAGTATAAGTTTCATTCGGGGCAGTGGGTGGAGTGGAGGTTTCTGGGGAGGACTCCAGTGCCGAGATCTGCACATGGGGCTGCGGTATTCGACGGGAAGTTGTGGATTTTTGCCGGCTATGATGGCAATGCCAGGTTGAATGATATGTGGACGATTTCTCTGACAGGTGACACCCACAGTTGGGAGGAGGTGATACAGAAAGGGGAATGTCCCCCCACCTGCTGCAACTTCCCCGTGGCTGTCGCCAGGGAGAGCATGTTCGTCTTCAGCGGACAAAGTGGAGCCAAAATCACAAATTCTTTATTTCAGTTTAACTTTAAGGAGAGATGCTGGACACGCATCAGCACCGAGCACATCCTCCGCGGAGCCCCGCCCCCTCCTGCACGCCGCTATGGCCACACCATGGTGGCCCACGACCGGCACCTGTACGTGTTCGGAGGCGCGGCAGACAGCACGCTGCCCAACGACCTGCACTGCTACGACCTGGACGCGCGGGCCTGGCACGTGGTGACGCCTGCAGCTGACAGCCACGTGCCCAGCGGCAGGTTGTTCCACGCCGCCGCCGTGGTCCAGGACGCCATGTATGTGTTCGGAGGGACGGTGGATAATAATGTGAGGAGTGGAGAGATGTTCAGGTTTCAGTTCTCCAGCTACCCCAAGTGCACGCTGCACGACGACTACGGCCGCATCCTGGAGTCGCGGCAGTTCTGCGACGTGGAGTTCATCATCGGCGAGGAAGAGGTTCGAATCCCGGCGCACATGGCTCTGGTGGCAGCGCGATCGCAGTGGCTGCGCGCGCGCATCCGACAAGCTAGGGAACAGAGAGACAAGGTGCTGGAGAAACAGATGCAGGACAAGGAGAAGGCGACCAACAAGGAAGTGAAGGAAGTGAAGGATACGCCTTTGGTGGAGGTGAAGCTCCTCGACGCCGTCCCCGAAGCGTTCCAAATGGTCCTCAACTACATCTACACAGACCGCATCGACCCGACCCGGACCGGCAGCGAGGACCCGTTCTCCAACCGCATCGTGTTGCTGATGATGGACGTGTACCGCCTGGCGGTGCTGTGCTGCATGAGGCGGCTGGAGACGTTGTGTGTCCAGTACCTGGAGGCGGCGGTGAGCCTTCGGAACGTCCTCCAGGCGCTCCACAACGCCGCGAGGCTTCGCCTGGATTTCATACAAGAGTTTTGTCTTAGGTTCATTGTGAAGGACTCCAATTATAATCAGATTGTAATGTCCCGCGAGTTCGAGACCCTGGACCGGCAACTAATGGTGGACATCATCCGGCGGCGGCAGGTGCCAGCGGGACGCGCGCCGGAGCCCCGCTGCGAGGCCGCCGCCCCCGGGCCCGGCGCCTCGCTCGAGCAGGACCTGGCGCTGTTCCTCAAGTCCACTGGCCATGACTTCTGTGACATTACTCTGCTGCTGGATGGACACGGGATCCCGGCGCATAAGAGTGTGCTGGCTGCCAGGTGTGGTTATTTCGAGGCGATGTTTCGATCGTTCATGCCCGCGGACAACACCGTGAGGATACAAATCGGAGAGATGACGCCCAGCAGAGAAAGCTTCGACTCTTTGTTGAGATATATCTACTACGGGGATGTGTCCATGCCTCCAGAGGACTCCCTCTACCTGTTCTCAGCGCCATTTTTCTACGGCTTCACAAACAACCGCCTCCAGGCATTCTGCAAACAAAATCTAGAAATGAACGTCACTTTCGAAAACGTCATCCAAATTTTAGAGGCTGCTGACAAAATGCAAGCGACAGATATGAAGAAATACGCACTCAACATGATCGTTCATCACTTTTCTAAGGTTGCCCGCCTGCCGAAGATGCGCACGCTGAGCAGGGAGTTAATTTTGGATGTGTTGGAAGCCCTGGCTGATGACATGAGTGATAATAAGATGTGCCAGGATATGTCGTCGGTTAGTTTGAGCAGCgattga
Protein Sequence
MGVNLTENRIAADASELPVQVSYGPEPENQSDISSEKETNENFDTEVPLPETKNSEEVVKEELVTPDSSYDFEFVNCIKSEPIHEPEISISNVDVPQMSVSVSNLPRDFEDTSRADSSAEVRVTVQMDASTSNASQVFDNGLTLYFGPFETVHRWKRMPECDEFVGARRSKHTVVAYKEAIYVFGGDNGKSMLNDLLRFDVKEKSWGRAFATGCPPAPRYHHSAVVHGTSMFVFGGYTGDIHSNSNLTNKNDLFEYKFHSGQWVEWRFLGRTPVPRSAHGAAVFDGKLWIFAGYDGNARLNDMWTISLTGDTHSWEEVIQKGECPPTCCNFPVAVARESMFVFSGQSGAKITNSLFQFNFKERCWTRISTEHILRGAPPPPARRYGHTMVAHDRHLYVFGGAADSTLPNDLHCYDLDARAWHVVTPAADSHVPSGRLFHAAAVVQDAMYVFGGTVDNNVRSGEMFRFQFSSYPKCTLHDDYGRILESRQFCDVEFIIGEEEVRIPAHMALVAARSQWLRARIRQAREQRDKVLEKQMQDKEKATNKEVKEVKDTPLVEVKLLDAVPEAFQMVLNYIYTDRIDPTRTGSEDPFSNRIVLLMMDVYRLAVLCCMRRLETLCVQYLEAAVSLRNVLQALHNAARLRLDFIQEFCLRFIVKDSNYNQIVMSREFETLDRQLMVDIIRRRQVPAGRAPEPRCEAAAPGPGASLEQDLALFLKSTGHDFCDITLLLDGHGIPAHKSVLAARCGYFEAMFRSFMPADNTVRIQIGEMTPSRESFDSLLRYIYYGDVSMPPEDSLYLFSAPFFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADKMQATDMKKYALNMIVHHFSKVARLPKMRTLSRELILDVLEALADDMSDNKMCQDMSSVSLSSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01275493;
80% Identity
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