Basic Information

Gene Symbol
Mbd3
Assembly
GCA_947538895.1
Location
OX384545.1:27661742-27663005[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.7e-22 3.1e-18 66.0 0.0 2 73 6 72 5 75 0.90
2 2 0.0005 2.4 8.7 0.0 29 74 122 175 94 178 0.85

Sequence Information

Coding Sequence
ATGAATTTAAACATCGAGCGGGGGAAAACTGAGTGTAACGCGCTCCCAAAGGGCTGGCAGCGGGAAGAAGTCCTGCGAAGGACAGGACTGTCTGCTGGGAAGGTTGATGTTTACTATTACAGTCCCACCGGAAAAAAAATCGAAAATAAACCACAGCTAGCTCGCCAGCTGGGCGACGTCCTCGATGTCTCAACATTTGATTTTCGCACTGGCAAATTATTACCACACGCCCAGCAAATTTCAGTCCAGCGAACAGCGAGCTCCCTCAAGCGAAAGTTGCCCGCCGGAACGACGGCTATTTGTAACCCTACCAGTAGTAGTATGTCGTCAGCATTTCGCCATCATCTAGAACTCAGTCGTGGCATGCGGAACGACATATCGCTTGTGCCCCCGATCCGCCAAACTGCCTCCATATTCAAGCAGCCAGTCACTGCTGTGAAGAACCAGGAAGGGAAGGTTAAGCACGACCTAAAGAACGTGTCCCAGGAAAAGCCCAAGCAGCTCTTTTGGGAGAAGCGCCTAGAAGGGCTGAGAGCTTGTGATATCTCCGGATCAGAGTACGAGTCCATAGATCTGCCGAAAGGTATAAAGCCCGTAGGACCAAACGTTGCCGAGCACACAGTACTCCAGTCGGTTGCAACAGCCCTACATGTCTCGAACCAGCCGGTGACCGGACAAACTGCTTCTAAAAACGCCCTCACTACTAACTCCGGGGCCTTTCTAAATCCCGAACAGCCTCTGATGCACGTGATAGGAATCACAGAAGACGACATCCGGAAGCAGGAAGAACGGGTCTCACTAGCCCGGCGGAGACTCCAAGAGGCTCTAAAAGGTTAA
Protein Sequence
MNLNIERGKTECNALPKGWQREEVLRRTGLSAGKVDVYYYSPTGKKIENKPQLARQLGDVLDVSTFDFRTGKLLPHAQQISVQRTASSLKRKLPAGTTAICNPTSSSMSSAFRHHLELSRGMRNDISLVPPIRQTASIFKQPVTAVKNQEGKVKHDLKNVSQEKPKQLFWEKRLEGLRACDISGSEYESIDLPKGIKPVGPNVAEHTVLQSVATALHVSNQPVTGQTASKNALTTNSGAFLNPEQPLMHVIGITEDDIRKQEERVSLARRRLQEALKG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00717805;
80% Identity
-