Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.5e-22 2.1e-18 66.2 0.0 1 65 53 119 53 119 0.93

2 3 3.3 1.5e+04 -3.9 0.0 12 29 126 142 125 143 0.67

3 3 5.2e-17 2.5e-13 49.9 0.1 1 64 154 244 154 245 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.5e-22	2.1e-18	66.2	0.0	1	65	53	119	53	119	0.93
2	3	3.3	1.5e+04	-3.9	0.0	12	29	126	142	125	143	0.67
3	3	5.2e-17	2.5e-13	49.9	0.1	1	64	154	244	154	245	0.90

Coding Sequence: ATGTATGAAGATGACAACATCACTTGTACGCCGAAGCGCTGCGTTCTGACCGAGGTTACGAACTCGTCCAGTTATGTGTCGCCGACCGCTAACCTCAAGCTGTTGACCAATGTCGCGTTGCAGTACCCCACGCCCCCGCCCAGTGCGGTGCAGCGCAAAGAGAAGTCGCTCCAAATTTTATGTGATAGATTCCTCAACCTCTATCCACTATATGGGAATGGGACCATGGAAATTCAGCTGGATAGCACTGCGGGCCGGCTAGGAGTGGAAAAGAGGCGAATGTACGATATAATCAACATACTTGAAGCTATGCAGTGTGCAGTGCACAAGAGGAAAAACACTTATTTGTGGCATGGAGGTGCTCGGTTGAATGCTTTCTTGAAAATGTTGAGGAAGCAAGGGGAGACCTTGAGGCTTTCGGATGTCTTGCGTGGAAGGGCTCCTAAACCACCAACACCAAAACATAAGACACTAGGAGTGCTGGCGCAGAGATTCCTGATGCTGTTTTTGGTTGAACCACCTAATACTCTAATAAACCTGGAAATGGCAGTGCGAGTCCTCATCGACACATCAAGCAAAAACAAAAGCACACTGTCACCGGAGCAACAAGAGCGCCAGCACAAATCCAAAGTGAGGCGACTATACGACATTGCTAATGTATTTATTTCTATTGGTCTCATAGAGAAAGTTTCTGGTAATTTAATTTTAAAGAAACCCGTATTTAAATATGTAGGACCGTACAAACCTAAAAAGGCTGATAAGATGGTAGCTTTACCATCTCCGATTACACCGTTGTCTGTGTTAGACAATCAAAGAGTAGCTACATGTCATGTGTTTGCCGGGAAGTCAAAACGGAAGCTGGAGTTCACCACTCCCACCACTTCCAAAGAACTGAAGTTTGGCATCACGACTCCTCCCCACACTCCTTCCCAGAAGTGGGATGAAATCTTACTTGTTGCCGACATGGAACTGACTAGAATTAACAATGGTGTTATGTTGTGA
Protein Sequence: MYEDDNITCTPKRCVLTEVTNSSSYVSPTANLKLLTNVALQYPTPPPSAVQRKEKSLQILCDRFLNLYPLYGNGTMEIQLDSTAGRLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGARLNAFLKMLRKQGETLRLSDVLRGRAPKPPTPKHKTLGVLAQRFLMLFLVEPPNTLINLEMAVRVLIDTSSKNKSTLSPEQQERQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPYKPKKADKMVALPSPITPLSVLDNQRVATCHVFAGKSKRKLEFTTPTTSKELKFGITTPPHTPSQKWDEILLVADMELTRINNGVML

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00967840;
90% Identity: iTF_00926383; iTF_00142885; iTF_00818151; iTF_00055192; iTF_01443623; iTF_00250252; iTF_00033613; iTF_00634105; iTF_00032699; iTF_00790033; iTF_00790990; iTF_00834418; iTF_00837260; iTF_00836310; iTF_00835341; iTF_00935475; iTF_00649817; iTF_00648901; iTF_01172121; iTF_00044251; iTF_00390171; iTF_00205853; iTF_00895713; iTF_00909542; iTF_00826616; iTF_00825376; iTF_00206787; iTF_00666301; iTF_00124958; iTF_01207903; iTF_01208996;
80% Identity: -