E2F
- Domain
- E2F_TDP domain
- Group
- Helix-turn-helix
- PFAM
- PF02319
- Desciption
- This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
- Rederence
-
- In vivo association of E2F and DP family proteins. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA. Mol. Cell. Biol. 15, 2536-46, (1995).
- Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Zheng N, Fraenkel E, Pabo CO, Pavletich NP. Genes Dev. 13, 666-74, (1999).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000107 | Abrostola tripartita | Atri020468.1 | e2f7 |
| iTF_00000108 | Abrostola tripartita | Atri020587.1 | E2f3 |
| iTF_00000109 | Abrostola tripartita | Atri003060.1 | E2F4 |
| iTF_00000110 | Abrostola tripartita | Atri010157.1 | TFDP1 |