Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.8e-22 1.3e-18 67.1 0.0 1 65 55 121 55 121 0.92

2 3 1.2 8.7e+03 -2.8 0.0 11 29 127 144 126 146 0.72

3 3 6.1e-17 4.6e-13 49.4 0.1 1 64 156 246 156 247 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.8e-22	1.3e-18	67.1	0.0	1	65	55	121	55	121	0.92
2	3	1.2	8.7e+03	-2.8	0.0	11	29	127	144	126	146	0.72
3	3	6.1e-17	4.6e-13	49.4	0.1	1	64	156	246	156	247	0.89

Coding Sequence: ATGTATGAAGATGACAACATCACTTGTACGCCTAAGCGCTTCGTGCTCACTGAAGTCACAAATTCGTCCAGCTATGTGTCGCCCACAGCTAACCTCAAGCTGTTGACCAATGTTGCGCTGCAATACCCCACGCCGCCGCCGAGCGCCAGCGCGGTGCAGCGCAAGGAAAAGTCTCTTCAGATTCTATGTGATAGATTCCTCAACCTCTATCCACTTTACGGCAATGGAACCGTGGAGATTCAGCTGGACAGCACTGCAGCCCGGTTAGGTGTGGAAAAACGGCGAATGTATGACATAATCAACATACTTGAAGCCATGCAATGTGCAGTGCACAAGAGAAAAAACACATATTTATGGCATGGGGGAGCTCGGTTGAATGCTTTCTTAAAAATGTTAAAGAAGCAAGGAGAGACCTTGAGGCTTTCAGATGTACTACGAGGGAGAGCTCCAAAACCACCAACACCAAAACATAAAACATTAGGAGTGCTGGCTCAAAGATTCCTGATGCTATTCTTAGTTGAACCATCTAATACTCTAATAAACCTGGAGATGGCTGTGCGAGTCCTGATAGACACATCTAGCAAGAACAGGACTACACTCTCTCCAGAGCAACAGGAGCGTCAACACAAATCCAAAGTGAGACGGCTGTATGACATTGCCAATGTATTTATTTCTATTGGTCTCATAGAAAAGGTTTCTGGTAACTTAATATTAAAGAAACCTGTATTTAAATATGTAGGGCCATACAAACCTAAAAAGGCTGATAAGATGGTAGGTACACCATCGCCAATTACACCATTATCTGCTTTAGACAATCAGAGAGCTTCCACATGTCAAGTGTTTGCTGGAAAGTCCAAACGGAAGCTGGAATTCACTACTCCCACCACTTCCAAAGAACTGAAGCTCTGTACCACCACTCCCCCTCATACCCCATCACAGAAGTGGGATGAGATCTTACATGTTGCTGGCATGGAACTGACTAGAATTAACAATGGTGTAATGTTGTGA
Protein Sequence: MYEDDNITCTPKRFVLTEVTNSSSYVSPTANLKLLTNVALQYPTPPPSASAVQRKEKSLQILCDRFLNLYPLYGNGTVEIQLDSTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGARLNAFLKMLKKQGETLRLSDVLRGRAPKPPTPKHKTLGVLAQRFLMLFLVEPSNTLINLEMAVRVLIDTSSKNRTTLSPEQQERQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPYKPKKADKMVGTPSPITPLSALDNQRASTCQVFAGKSKRKLEFTTPTTSKELKLCTTTPPHTPSQKWDEILHVAGMELTRINNGVML

Sequence clustering based on sequence similarity using MMseqs2