Lari012672.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Leptophobia aripa
Gene Symbol
MBD-R2
Assembly
GCA_951799465.1
Location
OX637278.1:2518057-2527801[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.7e-16 1.8e-12 46.7 0.0 6 58 718 770 713 808 0.91

Sequence Information

Coding Sequence
ATGGCAGAAAAACAGTGTTGCATAGAATGTTGTACTTCCTCATCATCGAGAAACGAAGACGTCGGAGTAACATATCATAAATTTCCCAAAGATCTACGTACATATAATACTTGGATTCATTTTACTCACACTAAACCTAACACTgacaataatatgtatgtgtgttCAAGACATTTCtgtaaaaatgattttcaaatatatcagGAATCAAAATATGTACTGAAGTCAGGTGCCGTGCCATCAATTTTTCCTTGGACAATGGCAGAAGGCAATGAAGCTTCTGACACTAAAATTGagaacatatttaacgatGATCATGATGACATTATTGATGCATCCAACAGTAGGCTAGATTCTGAACTAGAGAATAtagaatcaataaaaaaattcatcgAAGAACAACATCAAACTGTGAATGCAGACAATTTGACCACTTTAAGTGGTTTGAGTGCAACAGCTTTAGATGTAATACACATGTCCCAAGACACTCCAATGACAGCCAATAGCgatgttaataatgttattatttctgAAAGTTCTAATGTAAAGATAAATCAAAAAGAAcaaattaaagatataaaccAATGTGATAAGGGCACAGTAGCATTAAAAGTGGGTAGTAAAGTGGAAGCAAAGGACTTTGGCAGTCAGTGGCATGCTGCATCTATAGTTGAAGTAGATTATGATGAGGTGGAGGTCTTAGTTCACTATGAAAATTCTACTAACATGCCCGATGAGTGGATAAGCGTGAATAGTTCCCGTTTGCGACCCTATAATCCAAATCGGCCTCCTGAAGTTTTGGCGCTGAATATGCCGCCAAAACCAACAAGACCCACAAATATTCATACTGAAGATGAAATAAAGGTGGAAGAAAAGAAGAATGGTACATTTATTGAAGGAGAGAGATGCTTAGCACGTTGGAGagataataaaagatttatggctacaattcaaaattatttgggAAATGGTcagtatgaaattatttttgatgatGGATTCCAATGGAAGTGTTCAGTTTCAAGGttgcataaattaaaagattctTCTGGAAAGCATACTGATAATCTATCTGTAGATACATCAATGTCACCGAATACTTCAGCTCTGTCACCGTTGGCACCGGGCATTGGGCCACTGAGCAAGCCAGCATTCCACACACACTTGTTTGATCCCACCAGAGACTACTTGCCGTCCAAAAGTGAGCGTCGCGAAATGAAAAGAAAACTCAATATcaaggaaatatttaatattggtcAGAAAAAACGGAAAATTAAAACAGATGATGAACAGAAAAGTGTAAAGAAAAAGATTAAAAGTGAACCCAAACCTTTGGACATTAAGGAGTTACCAGATGCAGTTGCATCAATTATTGGCACTGTAGATGGTGTAGGCATAAAACATGAAACTGAATTAACTGAATGTAAAGAAGATGGATTGGACGATTTAATTGATAGAAAAGAGTCTTCATACCTGTCTGACTCTGATCCTGCTAACCGTTCGGATCCGGTTTCTAATGAAGAAGATACATTAGAGAGATTCGATAACACAGACGAAGGCATTAATGAAGCTGTAATAGACAAAATGAAGGAAGTGATAAGTAAACTGGAAGACGGtttgaataattcaaaaattatacaaGACGTAAAAGCACCTACGGAGCAAGAATCGAACCTGGAAGTGATACAAGTGGATCCCAATGATGGCGAAATTGATTTGGAAACCGAGGAGACGCATGCTGAtgtgaaaattgaaaatgagATGAAAACGGAAGTGCTAACGGAGTCTGATGATGTTCATGTGAAAATAGAAGAAAAGCCAAAGAAATTGGCATCCAAGGTGAAGAAGAGTAAAAAGTTGAGGTTGTTGCAGGAGAAGAAGGTTAAAAAGCAGGTGGAGAGGGTTAAGAGTGAGTTGGAAGAGATGAAGAAGCAGGTTGAAGAAATGCGAAAGCAAATGTTGCAGAAGACGGAGGAACTTGCCGCTCAACAACAGCAGCGGCCACCGCACGAAATGCCGGAGAGTTTCCTTCTGCCGGGCGAGTGGTGTTGCCGGTGGGTGAACGGCGAGCCGGTGGGACAAGTCCACGAGACGTTTGAGACGCGAACAGAGGCTCAGAAAAAGACTGCGTTGCCTAGACGCACTGTACTTgtCGAAGATAAACGTTTGCCAGATGGTTGGAAGAAAGTTATGGTGCGAAGGAGTTTGGGCCAATCTGCTGGTAAATGGGACGTTGTTTTACTAAGTCCGGATCAGAGGCGATTTCACACGAAGCAAGAGATGCGTACTTACCTCGATCAAACTCAGGGAGAGCTTAAAGCTTACGAAAACGCATTATTGGACTTTGGGGTGCATCTGAAATTGTCCCGCCGAATGGGATGGGTCTCCAACACGGGCCCAACAAACTCGGCCGTTTCAAATGTTTCGCTGTTTGTTCCTAGGAAGAAATTGATTCACAAAGATGCAAAGAAGAGGATCAATATACGGAAGCCGAATtaTATCTTAGAAAGACAAGGAGAAGTCGGACAGACACCAGGAAAAATTGATGAAACAGATCTTGACATGCAAAACCCTCCAATTGACAACGGATTTATATACGTCGGCTCCCTCCAAGTCCAAGTAATAGACAGCTTGCTGAGATGTCCCGCGGAAGGTTGCGTCAAAAACTTCAGAAATAACACACTCCTGAAGATGCACATAAAGCATTATCATCGCGAATTGAAGAAAAAGTTTGGAAATACACCGAAGGTTTTAGATCTGGCATACGCCCGCGCCAGGCCCACTGTCGGTAAAGTGAAAAAGAAGGTTATCAAAGTGAAAATCCCCAAACCTCAAAAATCGAATGTCGAACCCAAACCGGAAGTGATCGAACCGCAACCGGAACTATGTGTCAACGTGACGCCATTACCCACGGAGGAAACTCAAGATTCGCCGAAACTACGCCAAGCGCTGATACCGAAACCGGTGAAGGGTCCGAAAGTGTTGTTGCCGGTACGCAAACCGGAACCGGAAGGTTTAGATGAACAGTTGGATGTCGACTGTGTTGACTTTGAGACGGCAATTTCAACGCACACAGTTACAAAACCGggtgattttaatatagaaatcaAGGCGGCTTTCAGTGAGGACGACGAATGGCAGGGGAATTCGGATTTCGAGACTAGATCGAGCTTTCTCGGTTCCGGCACACCGGACTCGAAAACTATGGAGAAAATGACCACACCCCATTTGGGTGTTTCTTCCGAGTCCAATGAGGATGCGAAGGAAGCGGACATTTATATGTTCACGGAGACGGGTGAACGGATCAAAATCGAAAGGATGAAGCGTGAGGAGATAATAAATTGTCACTGCGGGTTCCGTGAAGAAGACGGTCTGATGGTGCAATGCGAGCTGTGCTTGTGCTGGCAGCACGCGCTTTGCCACAACATTCACACCGAAGGGGAGGTACCAGAAAAGTACACTTGCAGTATTTGCTTGAATCCAAAACGCGGTCGTCGGTCAAAGCGTTTCCTACACGATCAGGACAGATTGTACGAAGGCCTACTCCCGGGGGCGAAGCCCTGTGAATTCCTACGACGATCTCATGAACTGTCTGGCAATTTGCTCCGAATACAGGACGCACTGCACGCCATGCGAGTTAAATACTATGTCGCTACAAAAAAGAACCACCCAAAGCTATACCTCTGGGCGAAAGACTGGGAGAATGCTGAATTGAATTTCGCACAGGAAAGACTGAACTCGGACTACTCTGAcctgaatattattataaacaatattggaAAAGAGAATTTGCCAGTGAAAAGTCAGGATGAAGAGCGGGATACACTTCTTTCTGGATCAATTCCTGGTGTGCCCTTAGATTTTCCTATTAGTACTACCGAGTTGGAAAGAATGGCCAGGTCTATACaagagCAAGAGTCCCGTGTTTCAGCCCCGCAGCCCGAAGCGGCCATTGACAATAACGTGTGCCGGGAGCGATTGCTCAGACACGTGCAAAGGTGTCAGGCGCTCATTGACGCTAGACTCGACTCAATTGAAGCGCAGGTTGCTGAATTGGAATCTCAGGATCCTTCGTTTGAAGATGATGAAACTGCAGACTACTTCCCGCGTACAAAACAAACTATTCAAATGTTGATGCGAGATCTAGAAACTATGGAGGAGTTGGGAGTTATAACTTAG
Protein Sequence
MAEKQCCIECCTSSSSRNEDVGVTYHKFPKDLRTYNTWIHFTHTKPNTDNNMYVCSRHFCKNDFQIYQESKYVLKSGAVPSIFPWTMAEGNEASDTKIENIFNDDHDDIIDASNSRLDSELENIESIKKFIEEQHQTVNADNLTTLSGLSATALDVIHMSQDTPMTANSDVNNVIISESSNVKINQKEQIKDINQCDKGTVALKVGSKVEAKDFGSQWHAASIVEVDYDEVEVLVHYENSTNMPDEWISVNSSRLRPYNPNRPPEVLALNMPPKPTRPTNIHTEDEIKVEEKKNGTFIEGERCLARWRDNKRFMATIQNYLGNGQYEIIFDDGFQWKCSVSRLHKLKDSSGKHTDNLSVDTSMSPNTSALSPLAPGIGPLSKPAFHTHLFDPTRDYLPSKSERREMKRKLNIKEIFNIGQKKRKIKTDDEQKSVKKKIKSEPKPLDIKELPDAVASIIGTVDGVGIKHETELTECKEDGLDDLIDRKESSYLSDSDPANRSDPVSNEEDTLERFDNTDEGINEAVIDKMKEVISKLEDGLNNSKIIQDVKAPTEQESNLEVIQVDPNDGEIDLETEETHADVKIENEMKTEVLTESDDVHVKIEEKPKKLASKVKKSKKLRLLQEKKVKKQVERVKSELEEMKKQVEEMRKQMLQKTEELAAQQQQRPPHEMPESFLLPGEWCCRWVNGEPVGQVHETFETRTEAQKKTALPRRTVLVEDKRLPDGWKKVMVRRSLGQSAGKWDVVLLSPDQRRFHTKQEMRTYLDQTQGELKAYENALLDFGVHLKLSRRMGWVSNTGPTNSAVSNVSLFVPRKKLIHKDAKKRINIRKPNYILERQGEVGQTPGKIDETDLDMQNPPIDNGFIYVGSLQVQVIDSLLRCPAEGCVKNFRNNTLLKMHIKHYHRELKKKFGNTPKVLDLAYARARPTVGKVKKKVIKVKIPKPQKSNVEPKPEVIEPQPELCVNVTPLPTEETQDSPKLRQALIPKPVKGPKVLLPVRKPEPEGLDEQLDVDCVDFETAISTHTVTKPGDFNIEIKAAFSEDDEWQGNSDFETRSSFLGSGTPDSKTMEKMTTPHLGVSSESNEDAKEADIYMFTETGERIKIERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIHTEGEVPEKYTCSICLNPKRGRRSKRFLHDQDRLYEGLLPGAKPCEFLRRSHELSGNLLRIQDALHAMRVKYYVATKKNHPKLYLWAKDWENAELNFAQERLNSDYSDLNIIINNIGKENLPVKSQDEERDTLLSGSIPGVPLDFPISTTELERMARSIQEQESRVSAPQPEAAIDNNVCRERLLRHVQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLETMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00878909; iTF_01206566; iTF_01206615; iTF_01202483; iTF_01202527; iTF_01203303; iTF_01203258; iTF_01205763; iTF_01205718; iTF_01204915; iTF_01204961;
90% Identity
iTF_00878909;
80% Identity
iTF_00878909;