Pnap011889.1
Basic Information
- Insect
- Pieris napi
- Gene Symbol
- MBD-R2_1
- Assembly
- GCA_905475465.1
- Location
- FR997715.1:7082783-7096420[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.6e-16 7.6e-13 48.3 0.1 5 58 729 782 725 828 0.90 2 2 0.75 3.7e+03 -1.9 0.0 31 57 933 961 916 984 0.71
Sequence Information
- Coding Sequence
- ATGGCCGAAAAACAGTGTTGCATAGAAAATTGTACTTCCTCATCATCAAGAAATGAAGACGTTGGAGTGACATATCATAAGTTTCCCAAAGATCTAGATATTTACAATAGTTGGATTCGTATTACCCATACAAGACCTAACACTCACAATAATTTGTATGTGTGTTCAAGGCATTTTTGTAAAAGTGATTTTCAAGTGTATCAAGAATCAAAATATGTACTAAAGTCAGGAGCACTGCCATCAATATTTCCTTGGACAATGGCAGAAGACAATGACTTTCCTGAGGCTCAAATTGGCAGTTTATTTAAAGATGATAATTTTAATACATCCAATAGCATCAAAGAAGCAGACCCAGAGAATATAGACTCAATAAAGAAATTCATTGAAGGTCAACATCAAATGACAGAGAATGTTGACAAAATGAACACTTTAAGCGACTTAAACCTAAGTGTAACAGCTTTAGATGTAATACACAAGTCCCAAGAGACACCAATAATAGCTAATACTGTTATGAATATGATTATTAATAGTTCAAATGCCAAGGTAAATCAAAAAGAAGAAATTAAATATAACGTAAACCACTGTGATAAGGGCACAGTGTCATTGAAAGTTGGCAGTAAAGTGGAAGCAAAAGACTTTGGTGGTCAGTGGCATGCTGCATCTATAGTTGAAGTTGATTATGATGAGGTGGAGGTCTTAGTTCATTATGAAAATTCTACTAATATGCCAGATGAATGGATAAGCGTGAATAGTTCTCGTTTGCGACCTTTTAAATTAAATCGCCCCACTGAAGTAGCGACGCCAAATATGCCGCCAAAACCCACTGGACAGAGTACAGAAATTCTTCCTAAAGATGAAATTAAGGTGGAAGAAAAGAAAAAAGTAACTTTTATTGAAGGAGAGAGGTGTTTAGCGCGTTGGAGAGACAATAAAAGGTTTATGGCTACGATTCAGAATGCCTTGGGTCATGGTCAATATGAAATTGTGTTTGATGATGGGTTCCAGTGGAAATGTTCAGTTACAAGGTTGCATAAATTAAAAGATTCCTCCGGAAAACCTTTTGAGAATCTATCGGTAGATACATCAATGTCACCGAGCACTTCAGCGTTATCTCCGCTGTCACCAGGCATTGGGCCGCTTAGTAAGCCGGCATTCCATACGCACCTCTTTGATCCCACCAGAGACTACTTAGGATCCAAAAGCGAGCGTCGGGAAATGAAAAGAAAACTTAATATTAAGGAAATTTTTAATATCGGTCAGAAAAAGCGGAAAATAAAGCCAGAAAACACTGAACCAAAAAGTATAAAAAGGACAATAAAAATTGAACCTAAACCTGAGGAAATTAAGAAAGAATTACCGGACGCAGTTGCATCAATTATTGGTACTGTAGATGGTAAGGAGCCCGAAGACACAAAACTAGAAACACCTGAAAGCAACGATGAAGGTGATGAAAAAATAACTCTGGATGATATCATTACTCCAAAGGAAGCTTCGTACTGGTCAGACTCTGATGCTGCTAACCGCTCGGACCCGGTTTCTAATGAAGAAGATACTCTAGAACAATTCGATAATCCCGACGAAAGTATAAACGAAGCAGTAATTGATAAAATGAAAGAAGTAATCAGTAAACTAGAAGATAGTTTGAATAAAGTGGAAAGTATAGAAGACGTAAAAGAAACACCAGAGCCAGAAATAAATCTCGAAGTCATACAAGTCGATCCTAATGACGTGGAAATTGATATAGAAACGGAAGAAATAGATAAAATTGAAACGAAAATTGAAGATGAAATCAAAACAGAACAAACAACTGAACCAAATGATGTAAATAGACAGGTGAAAATCGAAGAAAAACCGAAGAAGTTAACATCCAAAGTAAAGAAGAGTAAAAAGTTGAGGTTGTTACAGGAGAAAAAGGTTAAAAAGCAGGTTGAGAAGGTTAAGAATGAGTTGGAAGAGATGAAAAAGCAGGTAGAGGAAATGAGAAAGCAAATGTTGCAGAAGACAGAAGAACTTGCTACGCATCAACAGCAGCGTGCAGCACCGAACGAAATGCCAATAAGTTTCCTCTTGCCGGGTGAGTGGTGTTGTCGGTGGGTTAATGGTGAACCAGTGGGACAAGTTCACGAGACGGTTGAGCCCCGTGGAGACACCCAAAAAAAACCCGCGTTGCCACGACGCACTGTGATGGTGGAAGATAAACGACTACCCGAAGGTTGGAAGAAAATTATGGTGAGAAGGAGTTTGGGACAATCTGCTGGAAAATGGGACGTCGTTTTACTCAGTCCGGATCAAAAGAGATTCCATACAAAGCAAGAGATGAGAACTTACCTCGATCAAACTCAAGGCGAGTTTAAAGCTTACGAAAACGCTTTATTGGACTTTGGGGTACATCTGAAGTTGTCCCGAAGAATGGGATGGGTTTCAAACACTGGACCCTCCAATGCACCCGTTTCGAATGTTTCACCATTTGTAAATAGAAAGAAATTGAGCACCAAAGATGGGAAAAAGAGGCTGAAGATACGGAAGCCAAATTATATCTTACAAAGACAAGGAGAAATAGGAGAACCATCAGAAATATCTGGTAAAACGAAAGAAACGGATCTTGATATGCAAAATCCTCCAATTGAAAATGGATTTATATACGTCGGATCTCTCAAAGTCCAAGTAATTGACAGCTTACTGAGATGTCCCGCGGAAGGTTGTCTCAAGAACTTCAGAAATAACACCCTCTTAAAAATGCATATAAAGCATTATCATCGCGAGTTAAAGAAAATGTTGGGTAAAACTCCAAAAGTCTTAGATCTGGCCTACGCTCGAACGAGGCCCACCGGCGAGAAAGTCAAAAAGAAAGTTATCAAAGTGAAAATTCCTAGAGTTCAAAAATCTGTTTTCGTCGATCCTAAACTGGAAGTGAGCGAGCCACAACCGGAACTACGCATCAACGTAACCCCATTACCCATGGAAGAGACACAGGAAGATTCGCCAAAACTTCGCCAAGCGCTTATACCAAAACCGGTAAAGCGTCCAAAAGTGTTATTACCGGTTCGTAAACCGGAACAGGAGGTCTCCGAAGACGATAAAACGGAATTGGAGTGTGTCGATTTCGAGGCTGCCATATCTACCCACACAGTAACAAAGCCGGGTGCTGACTTCAAACAAATAGAAATTAAACCTGCTTTTAGTGAGGATGAAGAATGGCCCTTACATTCTGATGTTGAAACTAGATCTAGTTTCCCTGGTTCTGGTACTCCGGACTCAAAGACAATGGATAAAGTGGCAACACCTAACCTAGGTGTATCACCAGAGTCAAACGAAGAGGCGAAGGAAGGGGAACTATACATGTTATCGGAAACTGGTGAACGAATTAAGATCGAGCGTATGAAGCGTGAAGAGATAATAAATTGCCATTGCGGCTTCCGGGAAGAAGATGGACTTATGGTACAATGCGAACTGTGTTTGTGTTGGCAACACGCGCTTTGCCATAATATTCACACTGAGGGAGAGGTACCAGAAAAATACACGTGCAGCATTTGTTTGAATCCGAAACGCGGTCGTCGGTCAAAGCGTTTCCTACACGATCAAGACAGATTGTACGAGGGCCTACTCCCTGGGGCTAAGCCCTGTGAATTCCTGCGCCGCTCTCATGAGCTCTCTGGCAATTTGCTGCGAATACAGGACGCTTTACATGCTATGCGAGTCAAGTACTATGTCACAACCAAAAAGAACCATCCAAAACTATACCTATGGGCCAAAGACTGGGAAAACGCTGAATTGAATTTCACGCAAGAGAGACTGAATTCCGATTATTCTGATCTCAACATTATCATAAATAATATTGGGAAAGAGAATTTGCCAGTTAAAAGTCAAGATGAGGAAAGGGAGGCACTTCTCAATCTCCCTGGATCAATTCCTGGAGTGCCTTTAGACTTTCCTATTAGTACCACGGAGTTAGAGAGAATGGCCAAGTCTTTACAAGAGCAAGAATCCCCTGTGTCAGCCCCACAACCTGAAGCACCAATTGATAATAATGTTTGTCGGGAACGATTACTAAGACATGTACAAAGATGTCAGGCGCTTATTGATGCAAGACTTGACTCTATTGAAGCGCAGGTTGCTGAATTGGAATCCCAAGATCCTTCATTTGAAGATGATGAAACCGCAGACTACTTCCCACGAACAAAACAAACCATTCAAATGTTGATGCGAGATCTTGAAAGTATGGAAGAGTTGGGTGTTATAACTTGA
- Protein Sequence
- MAEKQCCIENCTSSSSRNEDVGVTYHKFPKDLDIYNSWIRITHTRPNTHNNLYVCSRHFCKSDFQVYQESKYVLKSGALPSIFPWTMAEDNDFPEAQIGSLFKDDNFNTSNSIKEADPENIDSIKKFIEGQHQMTENVDKMNTLSDLNLSVTALDVIHKSQETPIIANTVMNMIINSSNAKVNQKEEIKYNVNHCDKGTVSLKVGSKVEAKDFGGQWHAASIVEVDYDEVEVLVHYENSTNMPDEWISVNSSRLRPFKLNRPTEVATPNMPPKPTGQSTEILPKDEIKVEEKKKVTFIEGERCLARWRDNKRFMATIQNALGHGQYEIVFDDGFQWKCSVTRLHKLKDSSGKPFENLSVDTSMSPSTSALSPLSPGIGPLSKPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKRKIKPENTEPKSIKRTIKIEPKPEEIKKELPDAVASIIGTVDGKEPEDTKLETPESNDEGDEKITLDDIITPKEASYWSDSDAANRSDPVSNEEDTLEQFDNPDESINEAVIDKMKEVISKLEDSLNKVESIEDVKETPEPEINLEVIQVDPNDVEIDIETEEIDKIETKIEDEIKTEQTTEPNDVNRQVKIEEKPKKLTSKVKKSKKLRLLQEKKVKKQVEKVKNELEEMKKQVEEMRKQMLQKTEELATHQQQRAAPNEMPISFLLPGEWCCRWVNGEPVGQVHETVEPRGDTQKKPALPRRTVMVEDKRLPEGWKKIMVRRSLGQSAGKWDVVLLSPDQKRFHTKQEMRTYLDQTQGEFKAYENALLDFGVHLKLSRRMGWVSNTGPSNAPVSNVSPFVNRKKLSTKDGKKRLKIRKPNYILQRQGEIGEPSEISGKTKETDLDMQNPPIENGFIYVGSLKVQVIDSLLRCPAEGCLKNFRNNTLLKMHIKHYHRELKKMLGKTPKVLDLAYARTRPTGEKVKKKVIKVKIPRVQKSVFVDPKLEVSEPQPELRINVTPLPMEETQEDSPKLRQALIPKPVKRPKVLLPVRKPEQEVSEDDKTELECVDFEAAISTHTVTKPGADFKQIEIKPAFSEDEEWPLHSDVETRSSFPGSGTPDSKTMDKVATPNLGVSPESNEEAKEGELYMLSETGERIKIERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIHTEGEVPEKYTCSICLNPKRGRRSKRFLHDQDRLYEGLLPGAKPCEFLRRSHELSGNLLRIQDALHAMRVKYYVTTKKNHPKLYLWAKDWENAELNFTQERLNSDYSDLNIIINNIGKENLPVKSQDEEREALLNLPGSIPGVPLDFPISTTELERMAKSLQEQESPVSAPQPEAPIDNNVCRERLLRHVQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLESMEELGVIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00878869;
- 90% Identity
- iTF_01204915;
- 80% Identity
- iTF_01205763;