Prap012261.1
Basic Information
- Insect
- Pieris rapae
- Gene Symbol
- MBD-R2
- Assembly
- GCA_905147795.1
- Location
- LR990601.1:5914052-5926732[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.7e-16 9e-13 47.8 0.0 6 58 737 789 732 821 0.90 2 2 0.38 1.3e+03 -0.7 0.0 31 57 940 968 922 1016 0.75
Sequence Information
- Coding Sequence
- ATGGCCGAAAAACAGTGTTGCATAGAAAATTGTACTTCCTCATCATCAAGAAATGAAGACGTTGGAGTGACTTATCATAAGTTTCCCAAAGATCTAAATATTTACAATAGTTGGATTCGTATTACCCATACAAGACCTAACACTGACAATAATTTGTATGTGTGTTCAAGGCATTTTTGTAAAAGTGATTTTCAAATGTATCAAGAATCAAAATATGTACTGAAGTCAGGAGCATTGCCATCAATATTTCCTTGGACGATGGCAGAAGGCAATGACTTTTCCGAGGCTCACATTGGCAGTTTATTTCAAGATGATCATAATGATAATGTAAATACATCTAATAGCATCAAAGAATCAGACCCAGAGAATATAGAATCAATAAAGAAATTCATTGAAGGTCAACATAAACATCATAAAATGACAGAGAATGAAGACAATTTGAACACTTTAAGCAACTTAAACTTAAGTGTAACAGCTTTAGATGTAATACACAAGTCCCAAGAGACACCTATAATAGCTAATAGTGTTATGAATATGATTATTGATAGTTCAAATGCAAAGGTAAAAAAGAAAGAAGAAATCCAATATAATGTAAACCACTGTGATAAGGGCACAGTGTCATTAAAAGTTGGCAGTAAAGTGGAAGCAAAAGACTTTGGTGGTCAGTGGCATGCTGCATCTATAGTTGAAGTTGATTATGATGAGGTGGAGGTCTTAGTTCATTATGAAAATTCTACTAATATGCAAGATGAATGGATAAGCGTGAGGAGTTCTCGTTTGCGACCTTATAAACCAAATTGGCTTACTGAAGTAGCGGCGCCAAATATGCCGCCGAAGACCACTGGACAGAGTACAGAAATTCTTCCTAATGATGAAATTAAGGTGGAAGAAAAGAAAAAAGTAACTTTTATTGAAGGAGAGAGGTGTTTAGCGCGTTGGAGAGACAATAAAAGGTTTATGGCTACAATTCAGAATGATTTGGGGAATGGTCAATATGAAATTGTGTTTGATGATGGATTCCAGTGGAAGTGTTCAGTTACAAGGTTGCATAAATTGAAAGATTCTTCCGGAAAACCTTTTGAGAATCTGTCGGTAGAAACATCAATATCACCAAGTACTTCAGCGTTGTCTCCGCAGTCACCAGGCATAGGGCCGCTGAGTAAGCCGGCATTCCATACGCACCTCTTTGATCCCACTAGAGACTACTTAGGATCCAAAAGCGAGCGTCGTGAAATGAAAAGAAAACTTAATATTAAGGAAATATTTAATATCGGTCAGAAAAAGCGGAAAATAAAACCAGAAAACACTGAACCAAAAAGTGTAAAAAAGAAAATAATAATTGAACCTAAACCTTTGGAAATTAAGAAGGAATTACCGGACGCAGTCGCATCAATTATTGGAACTGTAGATGGTAAGGTGCTCGAAGACACAAAACTAGAATCACCTGAAAGCAACGATGAAGGTGGTGAAAAAATAACTTTGGATGATTTGATTACTTCAAAGGATGAAGCTTCGTACTTGTCAGACTCTGATGCTGCTAACCGCTCAGACCCGGTTTCTAATGAAGAAGATACTCTTGAAAAATTTGATGATCACGACGGAAGTATAAACGAAGAAGTAATCGATAAAATGAAAGAAGTAATCAGTAAACTAGAAGATGGTTTGAATAAAGTGGAAAGTAAAGAAGACGTAAAAGATACACCAGAGCCAGAAATAAATCTTGAAGTTATACAAGTCGATCCTAATGACGTGGAAATTGATATAGAAACGGAAGAAATAGATAAAATTGTACCGATATTTAAAGATGAAATCAAAACAGAACAAACAACTGAACCAACAATGGATGTAAATAGACAGGAGAAAATAAAAGAGAAGCCGAAGAAGTTAGCATCCAAAGTAAAGAAGAGTAAAAAGTTGAGGCTGTTACAGGAGAAAAAGGTTAAAAAGCAGGTTGAGAAGGTTAAGAATGAATTGGAAGAGATGAAAAAGCAGGTTGAGGAAATGAGAAAGCAAATGTTGCAGAAGACAGAAGAACTTGCTACGCATCAACAGCAGCGTGCGGCAACGAACGAAATGCCAGTGAGTTTCCTCTTGCCGGGTGAGTGGTGTTGTCGGTGGGTTAATGGTGAACCTGTGGGACAAGTTCATGAGACGGTTGAGCCCAGGGCAGACACGAAAAAACCTGCATTGCCACGACGCACTGTGCTCGTGGAAGACAAACGACTACCGGAAGGTTGGAAGAAAGTTATGGTGAGGAGGAGTTTGGGACAATCTGCTGGAAAATGGGACGTTGTTTTACTCAGTCCGGATCAAAAGAGATTCCATACAAAGCAAGAGATGCGAACGTACCTCGATCAAACTCAAGGCGAGTTTAAAGCTTACGAAAACGCTTTATTGGACTTTGGTGTTCATCTGAAATTGTCCCGAAGAATGGGATGGGTCACCAACACTGGTCCCTCGAATGCTCCCGTTTCGAACGTTTCACCATTTGTCATCAGAAAGAAATTGAGTGCTAAAGATGGGAAAAAGAGGCTGAAGATACGGAAACCAAATTATATCTTACAAAGACAAGGAGAATTAGGAGAACCATCCGAAAAATCTAGCGAAACGAAAGAAACGGATATTGATATGCAAAATCCCCCAATTGAAAATGGGTTTATATACGTCGGATCTCTTAAAGTCCAAGTTATTGATAGCTTACTGAGATGTCCTGCGGAAGGTTGTCTCAAGAACTTCAGAAATAACACCCTCTTAAAGATGCACATTAAGCATTATCATCGCGAATTAAAGAAAATGTTGGGAAATACTCCGAAAGTCTTAGATTTGGCCTACGCTCGAACGAGGCCCACAGGCGAGAAAATCAAAAAGAAAGTTATCAAAGTGAAAATTCCTAGAGTTCAGAAATCGAATGTTCTCGTTGGTCCTAAACCGGAAGTGAGCGAGCCACAACCGGAAATACGCATCAACATAACCCCCTTACCCACAGAAGAGACACAAGAAGATTCGCCAAAACTTCGCCAAGCGCTCATACCAAAACCGGTAAAGCGTCCAAAAGTGTTATTACCGGTTCGTAAACCGGAACTCGAGGTCTCCGAAGACGATAAATTAGAATTGGAGTGTGTCGATTTCGAGGCTGCCATATCTACCCATACAGTAACAAAGCCGGGTGACTTCCAACGTTTAGAAATTAAACCTGCTTTTAGTGAGGATGAAGAATGGCCCTCACATTCTGATGTTGATACTAGATCCAGTTTCCCTGGTTCCGGTACTCCGGATTCAAAGATATTGGATAAAGTGGCAACACCTATCCCAGGTGTATCTTCAGAGTCAAACGAAGAAGCGAAGGAAGGAGAACTATACATGTTCACTGAAACCGGTGAACGAATTAAGATCGAGCGTATGAAGCGTGAAGAGATAATAAATTGCCACTGCGGGTTCCGGGAAGAAGATGGACTAATGGTACAATGCGAACTTTGTTTGTGCTGGCAACACGCGCTTTGCCATAATATTCACACTGAGGGAGAGGTACCAGAAAAGTATACATGCAGCATTTGCTTGAATCCCAAACGCGGTCGTCGGTCAAAGCGTTTCCTGCACGATCAAGACAGACTGTACGAGGGCTTACTCCCTGGGGCTAAGCCCTGTGAATTCCTGCGTCGCTCTCATGAGCTCTCTGGAAATTTGCTGCGAATACAGGACGCTTTACATGCCATGCGAGTCAAGTACTATGTCGCAACCAAAAAGAACCATCCAAAACTATACCTCTGGGCCAAAGACTGGGAAAACGCTGAATTGAATTTCACACAAGAGAGATTAAATTCTGATTATTCTGATCTCAACATTATCATAAATAATATTGGAAAAGAGAATTTGCCGGTTAAAACTCAAGATGAAGAAAGAGAGGCACTTCTAAACCTCTCTGGATCAATTCCTGGAGTGCCTTTGGACTTTCCTATTAGTACTACGGAATTGGAGAGAATGGCCAGGTCTATACAAGAGCAAGAATCCCGTGTGTCAGCCCCACAGCCTGAAGCACCGATTGATAATAATGTTTGTCGCGAACGATTACTGAGACATGTACAAAGATGTCAGGCGCTTATTGATGCAAGACTTGACTCTATTGAAGCGCAGGTTGCTGAATTGGAATCCCAAGATCCTTCATTTGAAGATGATGAAACTGCAGACTTTTTCCCACGAACAAAACAAACCATTCAAATGTTGATGCGAGATCTTGAAACTATGGAAGAGTTGGGGGTTATAACTTGA
- Protein Sequence
- MAEKQCCIENCTSSSSRNEDVGVTYHKFPKDLNIYNSWIRITHTRPNTDNNLYVCSRHFCKSDFQMYQESKYVLKSGALPSIFPWTMAEGNDFSEAHIGSLFQDDHNDNVNTSNSIKESDPENIESIKKFIEGQHKHHKMTENEDNLNTLSNLNLSVTALDVIHKSQETPIIANSVMNMIIDSSNAKVKKKEEIQYNVNHCDKGTVSLKVGSKVEAKDFGGQWHAASIVEVDYDEVEVLVHYENSTNMQDEWISVRSSRLRPYKPNWLTEVAAPNMPPKTTGQSTEILPNDEIKVEEKKKVTFIEGERCLARWRDNKRFMATIQNDLGNGQYEIVFDDGFQWKCSVTRLHKLKDSSGKPFENLSVETSISPSTSALSPQSPGIGPLSKPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKRKIKPENTEPKSVKKKIIIEPKPLEIKKELPDAVASIIGTVDGKVLEDTKLESPESNDEGGEKITLDDLITSKDEASYLSDSDAANRSDPVSNEEDTLEKFDDHDGSINEEVIDKMKEVISKLEDGLNKVESKEDVKDTPEPEINLEVIQVDPNDVEIDIETEEIDKIVPIFKDEIKTEQTTEPTMDVNRQEKIKEKPKKLASKVKKSKKLRLLQEKKVKKQVEKVKNELEEMKKQVEEMRKQMLQKTEELATHQQQRAATNEMPVSFLLPGEWCCRWVNGEPVGQVHETVEPRADTKKPALPRRTVLVEDKRLPEGWKKVMVRRSLGQSAGKWDVVLLSPDQKRFHTKQEMRTYLDQTQGEFKAYENALLDFGVHLKLSRRMGWVTNTGPSNAPVSNVSPFVIRKKLSAKDGKKRLKIRKPNYILQRQGELGEPSEKSSETKETDIDMQNPPIENGFIYVGSLKVQVIDSLLRCPAEGCLKNFRNNTLLKMHIKHYHRELKKMLGNTPKVLDLAYARTRPTGEKIKKKVIKVKIPRVQKSNVLVGPKPEVSEPQPEIRINITPLPTEETQEDSPKLRQALIPKPVKRPKVLLPVRKPELEVSEDDKLELECVDFEAAISTHTVTKPGDFQRLEIKPAFSEDEEWPSHSDVDTRSSFPGSGTPDSKILDKVATPIPGVSSESNEEAKEGELYMFTETGERIKIERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIHTEGEVPEKYTCSICLNPKRGRRSKRFLHDQDRLYEGLLPGAKPCEFLRRSHELSGNLLRIQDALHAMRVKYYVATKKNHPKLYLWAKDWENAELNFTQERLNSDYSDLNIIINNIGKENLPVKTQDEEREALLNLSGSIPGVPLDFPISTTELERMARSIQEQESRVSAPQPEAPIDNNVCRERLLRHVQRCQALIDARLDSIEAQVAELESQDPSFEDDETADFFPRTKQTIQMLMRDLETMEELGVIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00878869;
- 90% Identity
- iTF_01204915;
- 80% Identity
- iTF_01206615;