Celi011767.1
Basic Information
- Insect
- Crocallis elinguaria
- Gene Symbol
- PAX6
- Assembly
- GCA_907269065.1
- Location
- OU026076.1:5532069-5537192[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.9e-69 6.6e-66 220.5 0.2 1 116 32 147 32 151 0.99
Sequence Information
- Coding Sequence
- ATGCTGCCCGCGCAGCAGCTAGCCCCCATCAGCCCCTGGCCACCCGACGGCAACCTCCTCGACCGGATGGACGACTTGGCGCACAAAGGTAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGAGGGAGACCGCTTCCAGACTCCACGCGGCAGAAGATCGTGGAGCTGGCGCACTCGGGGGCGCGGCCCTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGCGTGTCCAAGATCCTCGGCAGGTACTACGAGACTGGCTCCATTAGGCCGCGAGCGATCGGGGGCTCCAAGCCCCGGGTCGCTACCGCGGAGGTCGTCAGCAAGATTGCGCAGTACAAGCGGGAATGCCCTTCCATCTTCGCCTGGGAGATCAGAGATCGCCTCCTGAGCGAGGGCGTTTGCACTTCGGATAATATACCTAGTAACCCTCCGGAGAACCTTTAG
- Protein Sequence
- MLPAQQLAPISPWPPDGNLLDRMDDLAHKGKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSNPPENL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01179457; iTF_00027714; iTF_01452290; iTF_00663043; iTF_00923651; iTF_00687844; iTF_00383622; iTF_01192683; iTF_00736589; iTF_00119568; iTF_00256882; iTF_00325344; iTF_01091882; iTF_00033773; iTF_00021295; iTF_00457199; iTF_01021175; iTF_01017696; iTF_01508032; iTF_00247155; iTF_00709203; iTF_00011956; iTF_00723925; iTF_01010327; iTF_00790232; iTF_01099802; iTF_01161321; iTF_00826939; iTF_01041724; iTF_00249663; iTF_00673471; iTF_01367872;
- 90% Identity
- iTF_00858512;
- 80% Identity
- iTF_01538717;