Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.17 1.6e+03 0.6 0.0 26 45 82 101 68 104 0.84

2 5 7e-05 0.66 11.5 0.2 23 46 107 130 101 133 0.90

3 5 8.9e-05 0.84 11.2 0.1 20 48 132 159 129 164 0.87

4 5 0.0033 31 6.1 0.1 21 52 161 192 158 192 0.88

5 5 0.00011 1 10.9 0.2 20 47 188 214 186 218 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.17	1.6e+03	0.6	0.0	26	45	82	101	68	104	0.84
2	5	7e-05	0.66	11.5	0.2	23	46	107	130	101	133	0.90
3	5	8.9e-05	0.84	11.2	0.1	20	48	132	159	129	164	0.87
4	5	0.0033	31	6.1	0.1	21	52	161	192	158	192	0.88
5	5	0.00011	1	10.9	0.2	20	47	188	214	186	218	0.89

Coding Sequence: ATGTTTGTCCAGAATAGGGCCCGAAACGGAATGTATTTAGATTCAAGAAGACTTTTAGGTTTAGCTGAATTGCGAAGGAGACTGCAAACATTGAAAATATCTCCGAAGATGGAGGAACCAAAGGTGGTCGATTTGAAGCTAGTTTACACATGTAGGAGATGCAAAATTAGTTTCAACACAAAACGTGAATCTCTACTTCATCGAAAAACGGCCCATGAAAGCAATCCAGCTGACAACAAGTACATTTGTGAAATATGCAACAAAGGCTTCGCAAATCCGGGCAACATGTACCGCCATTTGAAGGGTCACAGCGATGTTCGGCCGCACAGCTGCAAAATATGCGGAAGGGCATTTGCGCAGGCGGCCAACCTCCAGCGACACCTTTCGGTGCACAATGGCGAAAGACCTTATTCATGCCTTCTTTGCGAGAAGAGTTTCACCCAGCAAGGCAATCTTCGAAGGCATGAACTCACTCACACCGGGGAAAAACCCTTCCGCTGCAAAAGGTGTGGACGAATGTTTTCGCAGAGGGTCAATCTCAAAAAGCACGTTATGCTCCACCAAGGGTACAAGCCATTCAACTGTGAAGTTTGCCACAAATCATTCATTCAGGCGCAGAACTATAGGAAACATATGGAACGGcatgaaaatcatgaaaataaCACAACATCAACAACCTACAAAACTGAAAAGGCAGAATTATACTACGAGTGCGCATTGTGTAgagttatatttgcaaatttagAAGAATTCCAGTCGCATGAAATATTCTGCGAAGTAGCTGGAGAGGAACAGATAGAAACTACCACCACTACTACTTCTGCAACAGCAGTAACTGAAATAGTTGAGAGTACGTAG
Protein Sequence: MFVQNRARNGMYLDSRRLLGLAELRRRLQTLKISPKMEEPKVVDLKLVYTCRRCKISFNTKRESLLHRKTAHESNPADNKYICEICNKGFANPGNMYRHLKGHSDVRPHSCKICGRAFAQAANLQRHLSVHNGERPYSCLLCEKSFTQQGNLRRHELTHTGEKPFRCKRCGRMFSQRVNLKKHVMLHQGYKPFNCEVCHKSFIQAQNYRKHMERHENHENNTTSTTYKTEKAELYYECALCRVIFANLEEFQSHEIFCEVAGEEQIETTTTTTSATAVTEIVEST

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00424855;
90% Identity: iTF_00936929; iTF_01184195; iTF_00937511; iTF_00718189; iTF_00718001; iTF_01184022; iTF_00937688; iTF_01461369; iTF_01461564; iTF_00628606; iTF_00936767;
80% Identity: iTF_00628606;