Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.16 1.3e+03 0.4 0.0 26 45 51 70 45 73 0.85

2 5 4.2e-05 0.34 11.9 0.3 23 46 76 99 62 102 0.89

3 5 8.5e-05 0.69 10.9 0.1 20 48 101 128 98 130 0.89

4 5 0.0019 16 6.6 0.1 21 52 130 161 127 162 0.89

5 5 7.4e-05 0.6 11.1 0.2 20 47 157 183 155 187 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.16	1.3e+03	0.4	0.0	26	45	51	70	45	73	0.85
2	5	4.2e-05	0.34	11.9	0.3	23	46	76	99	62	102	0.89
3	5	8.5e-05	0.69	10.9	0.1	20	48	101	128	98	130	0.89
4	5	0.0019	16	6.6	0.1	21	52	130	161	127	162	0.89
5	5	7.4e-05	0.6	11.1	0.2	20	47	157	183	155	187	0.89

Coding Sequence: ATGATATCACCAACAATGGAAGAACCAAAAGTGGTTGATTTAAAGCTGGTTTACACCTGCAGGCGctgcaaaatttctTTCAACACAAAACGTGAATCTTTACTTCATCGGAAGACAGTCCACGAAGGTAATGCAGCTGATAACAAGTACATTTGCGAAATATGCAACAAAGGCTTTGCGAATCCCGGAAACATGTACCGCCATTTGAAGGGCCACAGCGACGTCCGGCCCCATAGCTGCAAGATTTGCGGAAGGGCGTTTGCGCAAGCGGCCAACCTCCAGCGACACCTTTCAGTGCACAACGGTGAAAGACCCTATTCATGTCTTCTTTGCGAGAAGAGCTTCACGCAGCAGGGAAATCTTCGAAGGCACGAACTGACTCACACCGGCGAGAAGCCATTCCGTTGCAAGAGGTGTGGTCGAATGTTTTCTCAAAGGGTCAACCTGAAAAAGCACGTTATGCTCCACCAAGGGTACAAGCCATTTAACTGCGAAGTTTGCCACAAGTCTTTCATTCAGGCCCAAAACTACAGGAAGCATATGGAGCGCCACGAAAACCATGAAAATACCACTACAACAGCAAGCTACAAGGCCGAAAAGGCAGaattATACTACGAGTGCGCATTGTGCAGAGTTATATTCGCCAATTTGGAAGAGTTCCAATCGCATGAGATATTCTGCGAAGTTGCTGGAGAGGAACAAATAGAAACTACTACTACAACAACGGCCGTAACTGAAATAGTTGAGAGTACGTAG
Protein Sequence: MISPTMEEPKVVDLKLVYTCRRCKISFNTKRESLLHRKTVHEGNAADNKYICEICNKGFANPGNMYRHLKGHSDVRPHSCKICGRAFAQAANLQRHLSVHNGERPYSCLLCEKSFTQQGNLRRHELTHTGEKPFRCKRCGRMFSQRVNLKKHVMLHQGYKPFNCEVCHKSFIQAQNYRKHMERHENHENTTTTASYKAEKAELYYECALCRVIFANLEEFQSHEIFCEVAGEEQIETTTTTTAVTEIVEST

Sequence clustering based on sequence similarity using MMseqs2