Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.28 1.9e+03 0.4 0.0 26 45 51 70 45 73 0.85

2 5 8.8e-05 0.6 11.6 0.2 23 46 76 99 70 101 0.89

3 5 0.00015 1 10.9 0.1 20 48 101 128 98 130 0.89

4 5 0.0043 29 6.2 0.1 21 52 130 161 128 161 0.88

5 5 0.0001 0.7 11.4 0.2 20 48 157 184 154 189 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.28	1.9e+03	0.4	0.0	26	45	51	70	45	73	0.85
2	5	8.8e-05	0.6	11.6	0.2	23	46	76	99	70	101	0.89
3	5	0.00015	1	10.9	0.1	20	48	101	128	98	130	0.89
4	5	0.0043	29	6.2	0.1	21	52	130	161	128	161	0.88
5	5	0.0001	0.7	11.4	0.2	20	48	157	184	154	189	0.88

Coding Sequence: ATGATATCACCAACGATGGAGGAACAAAAAGTGGTTGATTTGAAGCTGGTTTACACCTGCAGGCGCtgcaaaattactTTCAGTACAAAACGTGAATCTTTACTGCACCGAAAGACAGTCCACGAAGGCAATGCGGCCGATAACAAGTATATCTGCGAAATATGCAACAAAGGCTTTGCAAACCCAGGAAATATGTACCGCCATTTGAAGGGCCACAGCGACGTCCGGCCGCACAGCTGCAAGATTTGCGGAAGGGCGTTTGCGCAGGCGGCTAATCTCCAGCGACACCTTTCCGTACACAACGGCGAAAGGCCCTATTCGTGCCTTCTTTGCGAGAAGAGCTTCACCCAGCAGGGCAACCTTCGAAGGCACGAGCTCACCCACACCGGGGAGAAGCCCTTCCGCTGCAAGAGGTGCGGCCGGATGTTTTCCCAAAGGGTCAATCTTAAGAAGCACGTCATGCTCCACCAGGGGTACAAGCCTTTCAACTGTGAAGTTTGCCACAAATCTTTTATTCAGGCGCAGAACTACAGAAAACATATGGAGCGCCATGAAAACCACGAAGGTACCGCAACCACAACAAACTATAAGACCGAAAAGACGGAATTGTACTATGAGTGCGCTTTGTGCAGAgttatatttgcaaatttggaAGAGTTCCAATCGCATGAGATATTCTGTGAAGTGGCTGGAGAGGAGCAGATAGAAACTACTACTTCAACAAATGCTGTAACTGAAATAGTTGAGAGTACGTAG
Protein Sequence: MISPTMEEQKVVDLKLVYTCRRCKITFSTKRESLLHRKTVHEGNAADNKYICEICNKGFANPGNMYRHLKGHSDVRPHSCKICGRAFAQAANLQRHLSVHNGERPYSCLLCEKSFTQQGNLRRHELTHTGEKPFRCKRCGRMFSQRVNLKKHVMLHQGYKPFNCEVCHKSFIQAQNYRKHMERHENHEGTATTTNYKTEKTELYYECALCRVIFANLEEFQSHEIFCEVAGEEQIETTTSTNAVTEIVEST

Sequence clustering based on sequence similarity using MMseqs2