Dvar008446.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Drosophila varians
Gene Symbol
zfh1_2
Assembly
GCA_018150405.1
Location
JAECWK010000015.1:7144252-7164217[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.00028 0.027 14.7 1.9 2 23 73 95 72 95 0.95
2 7 0.0034 0.32 11.3 0.1 1 23 307 329 307 329 0.96
3 7 6.7e-05 0.0063 16.7 1.7 2 23 343 364 342 364 0.97
4 7 0.0045 0.42 10.9 0.7 2 21 645 664 644 665 0.92
5 7 6.4e-06 0.0006 19.9 0.5 1 23 985 1007 985 1007 0.95
6 7 3.2e-05 0.003 17.7 7.4 1 23 1013 1035 1013 1035 0.98
7 7 0.0016 0.15 12.3 4.3 1 21 1041 1061 1041 1062 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTTTGGCGCCGTCGTCTTCACGTTTCGGCCAAGAGGATACCATCATTCAGCAGAGCATGCCATCCACAGCCTTCACCATGCAGTTTCCCTCGCTAGCCTCCAGTCTGCACCACCATAACCATAACCAGTCGCCGCACCACAGCAAGCCTGGATCCCAGGATGGCCAGCACGTGCAACCAGGTGCCGCTGCCGATGATTTTCTGGTCAAGTGCACCCAGTGCCATAAGCGATTCACAGACTTCCAGTCCCTTAGTGAACACATTGCCAGCGAGCATCCCCACGACAAGTTAAATCTGGGTGCAGCGCATCCGGAAAGCGAGCCGGAGGACGAGCAGAGCAACTTAAGTAGCGGCAGTCGGAGATATCTGAAATCGCCAGCCACCAGTATTGGTAACACAAATGCCAACGGCAACAGCAGTATTGCCAACTCCAGCTGCAATAACAACAACAACAGTGATCTGGCCAAAAACCACAACAACACCAACAAGCTGTCGCCAATGTGCTCGCCCATTTCCGGTGTAGGAATGGGCGGTGTGGGAGCAGGTCCACCCAGCGATTTATTCGCCCACCTCTCGCATGCCACGCCCCAGCTGCCAGGTCAGCTGCCCGCCCATCTGCAGGCGCAGTTTATGGCCGCCGCCGCTCTGGCCATGCAATCCGCCCGCTCCGCCAGCTCCAGTTCCCCCAGCCACCTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCCGCCTACGATCTGGATCTGAGTGCACCACGATCCACCTCCAGTCCCGGCTCCACCACCGGAGATCTCAGTGGAGCATATCCCTGTATGCAGTGCACTGCAGCCTTCGCCTCCCGGGAGCAGCTGGAGCAACACGAGCTCCTCCACTCGCCCTGCGGCCAGCCAGCGGCCCAGAATGTCTCACAGACCTGCCGAATCTGCCACAAGGCCTTTGCCAACGTCTACCGACTCCAGAGGCACATGATAAGCCACGATGAGAGCGCCCTTCTCAGGAAATTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGGTTCTCCCACTCGGGAAGCTTTTCCTCCCACATGACCTCCAAGAAATGCATCAGCATGGGTCTCAAGCTCAACAACAATCGGGCTCTGTTGAAAAGATTGGAAAAGCGCCCAGGATCGGGATCGTCTGCCCGGCTCTCGCCCTCGGACCAGGCTAAAGGGAAGCTCCAGGAGCAACAGGCGTTGCCGGGACTACCAAATCCCATGATATACTTCGCCAGCGATGCTCAGAATCAGGCGGCTAACAATGGACCCGCGTCTTTTCCCAACTTTCATCCGAACTACATGAATGCCGCCCTTCTGGCCTTTCCAAATCCCTTCATGGCAGCTGCCGCCCTAGATCCTCGGATGCATCCCTATAGCATCCAGCGATTGCTGCAATTGACGGCTGCTGGTCAGCAACAAAGGGAGGAAGAACAGCGAGAGCAGGAGAACCAGGAGGATCAGGAGGAGGAAACCCCTGAGGAACCCAAACTGGTGATGGACATCGACGAGCCGGTGGTCAAGGAACGGATTGCCACCCCCCAAATTCATGAAGAGGCCGCTCCCATCAAGCAGGAGGCCAGTCTTGAGGCCACTCCGGCTCCGGAAAGTACTCCTCCATCGCCGCAGGTGGTTAAACAGGAAGCGGAGGCGCCACCGTTAGAGCAAGATGCCCAAATCATGGAGGAAGAACCCATTCCAGCTCCAGAACAGCCTGCTGATTTGCGCTGCAGTCGCTGCTCAAAGCAATTTAACCATCCCACGGAACTGGTGCAACACGAAAAGGTTCTCTGTGGTCTAATCAAAGAAGAAATGGAGCAACATTTCCAGCAACAACAGCAGCAGCAGCAGAACCTACAGCCACCAGCCTTTGTCCTGCCGTCCGCCAGCGAGGAAGATGATGAGGAAGAGGAGGAGGAGGAACCCAGAAACCAGGAGACAGGCGAACGAAAAGTCCGCGTGCGCACGGCCATAAACGAGGAGCAGCAGCAGCAACTGAAGCAGCATTATTCCCTAAACTCCCGACCCAGCAGGGATGAATTCCGCTTGATAGCAGCCAGGTTGCAACTGGATCCCCGGGTAGTGCAAGTTTGGTTCCAGAACAATCGGTCCCGCGAGCGAAAAATGCAGAGTTTCCAGAGCAACCAAAATGCCTCTGCGCCTCCCACAAATGAATCCCAACCCAATGGGTCCCGCGAGGATCAACCCTTGGATCTGTCTGTTAAGCGGGATCCTCTGACCCCGAAAAGCGAAAGCTCACCCTCTTACATGCCTCCACAGACGGCTGAAGGCCTGAATCCGGAAGCCATTAATCTGAGCAGGAAGTTCTCCAGCTCAGCTTCGATGTCGCCGGCTTCGATTTCCCCATCATCCGCGGCAGCTTTGTATTTTGGAGCCGCACCGCCACCATCACCACCAAACAGTCAACTGGAGACGAATCCTCCTCGCAGTAGCCAAGCCTTTCCGGGACTACCGTATATGCTACCCATGCAGAGACTGCCAATGGAGGCGCTATTCCAAATGCGACCAGGTGGGGAGTATGCACCGAATCATCCCCTGATGAACAGTATTAAGCTGCCCGACTACCGAGGCACCAGCCTAAGTCCGGGAGGATCGGAAAAACGCTCTTGGCGGGACGATGACTCGCGAATCTCGCACGAGGATGACTTCTCTGGCCTGCTTCCGCCAAAGCCTAGGAGGGGTAAGGCGGAGACCCATGGACACGCCGGCGATCCTGATTTGCCGTATGTGTGCGATCAGTGCGACAAGGCGTTTGCCAAGCAGAGTTCCCTAGCCCGGCATAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAACATAAGCACCATCTGACGGAGCACAAGCGTCTTCACAGTGGGGAGAAGCCTTTCCAATGCTCCAAGTGCCTAAAACGATTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence
MLSCLAPSSSRFGQEDTIIQQSMPSTAFTMQFPSLASSLHHHNHNQSPHHSKPGSQDGQHVQPGAAADDFLVKCTQCHKRFTDFQSLSEHIASEHPHDKLNLGAAHPESEPEDEQSNLSSGSRRYLKSPATSIGNTNANGNSSIANSSCNNNNNSDLAKNHNNTNKLSPMCSPISGVGMGGVGAGPPSDLFAHLSHATPQLPGQLPAHLQAQFMAAAALAMQSARSASSSSPSHLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFASREQLEQHELLHSPCGQPAAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKRPGSGSSARLSPSDQAKGKLQEQQALPGLPNPMIYFASDAQNQAANNGPASFPNFHPNYMNAALLAFPNPFMAAAALDPRMHPYSIQRLLQLTAAGQQQREEEQREQENQEDQEEETPEEPKLVMDIDEPVVKERIATPQIHEEAAPIKQEASLEATPAPESTPPSPQVVKQEAEAPPLEQDAQIMEEEPIPAPEQPADLRCSRCSKQFNHPTELVQHEKVLCGLIKEEMEQHFQQQQQQQQNLQPPAFVLPSASEEDDEEEEEEEPRNQETGERKVRVRTAINEEQQQQLKQHYSLNSRPSRDEFRLIAARLQLDPRVVQVWFQNNRSRERKMQSFQSNQNASAPPTNESQPNGSREDQPLDLSVKRDPLTPKSESSPSYMPPQTAEGLNPEAINLSRKFSSSASMSPASISPSSAAALYFGAAPPPSPPNSQLETNPPRSSQAFPGLPYMLPMQRLPMEALFQMRPGGEYAPNHPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDFSGLLPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE